1. Hong Zhu #, Guolian Ding, Xinmei Liu, Hefeng Huang*.Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns. Journal of diabetes. 2023;10.1111/1753-0407.13403.

  2. Cheng Li#Jing-Jing Xu#Fang-Yue ZhouYing-Zhou GeKai-Zhou QinHe-Feng Huang*, Yan-Ting Wu*. Effects of Particulate Matter on the Risk of Gestational Hypertensive Disorders and Their Progression. Environmental science & technology. 2023 Mar 13. doi: 10.1021/acs.est.2c06573. Epub ahead of print. PMID: 36913485.

  3. Yun-Fei Su#Cheng Li#Jing-Jing XuFang-Yue ZhouTao LiCong LiuYan-Ting Wu*, He-Feng Huang*. Associations between short-term and long-term exposure to particulate matter and preterm birth. Chemosphere. 2023 Feb;313:137431.

  4. Jin Yu#Yulai Zhou#Jie Ding#Danying Zhang 2Chaoqin Yu*, Hefeng Huang*. Characteristics and possible mechanisms of metabolic disorder in overweight women with polycystic ovary syndrome.Frontiers in endocrinology. 2023 Jan 12;13:970733.

  5. Wei Xia#Xiaofeng Wang#Yang WangYuan TianChuqing HeChenfeng ZhuQian ZhuHefeng Huang*, Liye Shi*, Jian Zhang*. Comparative effectiveness of transvaginal repair vs. hysteroscopic resection in patients with symptomatic uterine niche.Frontiers in surgery. 2023 Feb 9;10:1019237.

  6. Naixin Xu#Weihui Shi#Xianling CaoXuanyou ZhouLi JinHe-Feng HuangSongchang Chen*, Chenming Xu*. Parental mosaicism detection and preimplantation genetic testing in families with multiple transmissions of de novo mutations.Journal of medical genetics. 2023 Jan 27:jmg-2022-108920.

  7. Kalyanaraman Kumaran*, Catherine BirkenJean-Patrice BaillargeonCindy-Lee DennisWilliam D FraserHefeng HuangJianxia FanStephen LyeStephen G MatthewsShane A Norris. An intergenerational life-course approach to address early childhood obesity and adiposity: the Healthy Life Trajectories Initiative (HeLTI). The Lancet,Global health. 2023 Mar;11 Suppl 1:S15.

  8. Yi-Chen He#Kai-Zhen Su#Jie CaiQing-Xia MengYan-Ting Wu*, He-Feng Huang*. Serum anti-Müllerian hormone levels are associated with perinatal outcomes in women undergoing IVF/ICSI: A multicenter retrospective cohort study. Frontiers in endocrinology (Lausanne). 2023;14:1081069.

  9. Naixin Xu#Weihui ShiXianling CaoXuanyou ZhouHefeng HuangSongchang Chen*, Chenming Xu*. Preimplantation Genetic Testing (PGT) and Prenatal Diagnosis of Schaaf-Yang Syndrome: A Report of Three Families and a Research on Genotype-Phenotype Correlations. Journal of clinical medicine. 2023;12(4):1688.

  10. Fang-Yue Zhou#Cheng Li#Kai-Zhou QinChuan LuoHe-Feng Huang*, Yan-Ting Wu*. Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysis. Frontiers in pediatrics. 2023;11:992908.

  11. Ze-Han Dong#, Ting Wu#, Chen Zhang, Kai-Zhen Su, Yan-Ting Wu*, He-Feng Huang*.Effect of Frozen-Thawed Embryo Transfer on the Metabolism of Children in Early Childhood.Journal of clinical medicine. 2023;12(6):2322.

  12. Renke He#Jiaying MoKejing ZhuQinyu LuoXueying LiuHefeng Huang*Jianzhong Sheng*. The early life course-related traits with three psychiatric disorders: A two-sample Mendelian randomization study. Frontiers in psychiatry. 2023;14:1098664.

  13. Wei-Hui Shi#, Zhi-Yang Zhou#, Mu-Jin Ye, Ning-Xin Qin, Zi-Ru Jiang, Xuan-You Zhou, Nai-Xin Xu, Xian-Lin Cao, Song-Chang Chen, He-Feng Huang*, Chen-Ming Xu*. Sperm morphological abnormalities in autosomal dominant polycystic kidney disease are associated with the Hippo signaling pathway via PC1. Frontiers in endocrinology,. 2023;14:1130536.

  14. Jingchao Ren#, Huidong Jin#, Chen Zhang#, Song Liu, Yufen Han, Jinyan Xi, Jinhu Cao, Fenglong Lin, Pingyang Zhang, Fengquan Zhang, Guang-Hui Zhang, Huijun Yang*, Hefeng Huang*, Jia Cao*. Mixed exposure effect of seminal metals on semen quality, mediation of total antioxidant capacity, and moderation of GSTM1/GSTT1 gene deletion in Chinese reproductive-aged men.Environmental research. 2023;229:115888.

  15. Zhaoying Jiang#, Renke He#, Haiyan Wu, Jiaen Yu, Kejing Zhu, Qinyu Luo, Xueying Liu, Jiexue Pan*, Hefeng Huang*. The causal association between smoking initiation, alcohol and coffee consumption, and women's reproductive health: A two-sample Mendelian randomization analysis.  Frontiers in genetics. 2023;14:1098616.

  16. Dimitri Patrinos, Erika Kleiderman, William Fraser, Ma'n H. Zawati*, The HeLTI Consortium Shane Norris, Stephen Lye, Kalyanaraman Kumaran, Stephen Matthews, Cindy-Lee Dennis, Catherine Birken, Hefeng Huang. Developing Policy for the Healthy Life Trajectories Initiative: Going from National to International. Biopreservation and biobanking. 2023;10.1089/bio.2022.0198.


  1. Bin Chen#, Ya-Rui Du#, Hong Zhu#, Mei-Ling Sun#, Chao Wang#, Yi Cheng, Haiyan Pang, Guolian Ding, Juan Gao, Yajing Tan, Xiaomei Tong, Pingping Lv, Feng Zhou, Qitao Zhan, Zhi-Mei Xu, Li Wang, Donghao Luo, Yinghui Ye, Li Jin, Songying Zhang, Yimin Zhu, Xiaona Lin, Yanting Wu, Luyang Jin, Yin Zhou, Caochong Yan, Jianzhong Sheng, Peter R. Flatt, Guo-Liang Xu *& Hefeng Huang*. Maternalinheritance of glucose intolerance via oocyte TET3 insufficiency. Nature. 2022May;605(7911):761-766.

  2. Xu H, Li J, Jin L, Zhang D, Chen B, Liu X, Lin X, Huang Y, Ke Z, Liu J, GaoL, Sheng J, Huang H. Intrauterine hyperglycemia impairs endometrial receptivityvia up-regulating SGK1 in diabetes. Sci China Life Sci. 2022Aug;65(8):1578-1589.

  3. Zhu H, Cheng Y, Huang H. Diabetes predisposition inherited through maternalgermline. Clin Transl Med. 2022 Jul;12(7):e969.

  4. Li C, Yu JL, Xu JJ, He YC, Qin KZ, Chen L, Huang HF, Wu YT. Interactiveeffects of ambient air pollution and sunshine duration on the risk ofintrahepatic cholestasis of pregnancy. Environ Res. 2022 Dec;215(Pt 3):114345.

  5. Duan CC, Li C, Xu JJ, He YC, Xu HL, Zhang D, Yang JQ, Yu JL, Zeng WT, Wang Y,Chen L, Dennis CL, Wu YT, Huang HF. Association between prenatal exposure toambient air pollutants and postpartum depressive symptoms: A multi-city cohortstudy. Environ Res. 2022 Jun;209:112786.

  6. Mao Y, Zhao Y, Luo S, Chen H, Liu X, Wu T, Ding G, Liu X, Sheng J, Meng Y,Huang H. Advanced paternal age increased metabolic risks in mice offspring.Biochim Biophys Acta Mol Basis Dis. 2022 May 1;1868(5):166355.

  7. Xu Y, Zhou ZY, Pan JX, Huang HF. Associations Between Asthma and PolycysticOvary Syndrome: Current Perspectives. Front Endocrinol (Lausanne). 2022 Jul5;13:936948.

  8. Zhu SM, Zhang HQ, Li C, Zhang C, Yu JL, Wu YT, Huang HF. Maternal lipidprofile during early pregnancy and birth weight: A retrospective study. FrontEndocrinol (Lausanne). 2022 Sep 15;13:951871. IF=6.055

  9. Chen Q, Chen H, Wang M, Qiu L, Xi F, Jiang Y, Lv M, Huang HF, Luo Q. Theassociation between alteration of maternal lipid levels and birthweight at term:A within-family comparison. Front Endocrinol (Lausanne). 2022 Sep 30;13:989663.

  10. Zhu SM, Li C, Xu JJ, Zhang HQ, Su YF, Wu YT, Huang HF. Exposure toChloramine and Chloroform in Tap Water and Adverse Perinatal Outcomes inShanghai. Int J Environ Res Public Health. 2022 May 27;19(11):6508.

  11. Li XY, Pan JX, Zhu H, Ding GL, Huang HF. Environmental epigeneticinteraction of gametes and early embryos†. Biol Reprod. 2022 Jul25;107(1):196-204.

  12. Mo JY, Yan YS, Lin ZL, Liu R, Liu XQ, Wu HY, Yu JE, Huang YT, Sheng JZ,Huang HF. Gestational diabetes mellitus suppresses fetal testis development inmice†. Biol Reprod. 2022 Jul 25;107(1):148-156.

  13. Yan YS, Qu Z, Lv PP, Huang HF. Pediatric and adult obesity concerns infemale health: a Mendelian randomization study. Endocrine. 2022Feb;75(2):400-408.

  14. Zhang HQ, Li T, Li C, Hu HT, Zhu SM, Lu JQ, Chen XJ, Huang HF, Wu YT. LncRNATHOR promotes endometrial cancer progression through the AKT and ERK signalingpathways. Med Oncol. 2022 Sep 29;39(12):207.

  15. Zhao Y, Zhu Y, Chen X, Lin H, Qin N, Zhou Z, Liu H, Hao Y, Zhou C, Liu X,Jin L, Sheng J, Huang H. Circulating Innate Lymphoid Cells Exhibit DistinctiveDistribution During Normal Pregnancy. Reprod Sci. 2022 Apr;29(4):1124-1135.

  16. Yu JL, Su YF, Zhang C, Jin L, Lin XH, Chen LT, Huang HF, Wu YT. Tracking ofmenstrual cycles and prediction of the fertile window via measurements of basalbody temperature and heart rate as well as machine-learning algorithms. ReprodBiol Endocrinol. 2022 Aug 13;20(1):118.

  17. He R, Liu R, Wu H, Yu J, Jiang Z, Huang H. The Causal Evidence of BirthWeight and Female-Related Traits and Diseases: A Two-Sample MendelianRandomization Analysis. Front Genet. 2022 Aug 12;13:850892.

  18. Li Y, Jin L, Li Y, Qian J, Wang Z, Zheng X, Xie C, Zhang X, Huang H, Zhou Y.Lysophosphatidic Acid Improves Human Sperm Motility by Enhancing Glycolysis andActivating L-Type Calcium Channels. Front Endocrinol (Lausanne). 2022 Jul12;13:896558.

  19. Lin J, Gu W, Huang H. Effects of Paternal Obesity on Fetal Development andPregnancy Complications: A Prospective Clinical Cohort Study. Front Endocrinol(Lausanne). 2022 Mar 14;13:826665.

  20. Tian S, Zhang H, Chang HM, Klausen C, Huang HF, Jin M, Leung PCK. Activin Apromotes hyaluronan production and upregulates versican expression in humangranulosa cells†. Biol Reprod. 2022 Aug 9;107(2):458-473.

  21. Lin XH, Guo MX, Wu DD, Lu Y, Zhang JL, Zhou CL, Jin L, Wang L, Zhang C, XuCM, Chen SC, Zhang SY, Sun XX, Wu YT, Sun Y, Huang HF. Preimplantation genetictesting for aneuploidy in severe male factor infertility: protocol for amulticenter randomised controlled trial. BMJ Open. 2022 Jul 13;12(7):e063030.

  22. Hu XL, Shi S, Hou NN, Meng Y, Li M, Liu AX, Lu YC, Li JY, Sheng JZ, Zhu YM,Huang HF. High Maternal Serum Estradiol in First Trimester of Multiple PregnancyContributes to Small for Gestational Age via DNMT1-Mediated CDKN1C Upregulation.Reprod Sci. 2022 Apr;29(4):1368-1378.

  23. Duan CC, Yu JL, Tao J, Zhang C, Zhang D, Zeng X, Zeng WT, Xu HL, Qiu JY,Dennis CL, Jin L, Huang HF, Wu YT. Internet-based cognitive therapy for womenwith antenatal depressive symptoms during the COVID-19 pandemic: protocol for amulti-center randomized controlled trial across China. Trials. 2022 Sep21;23(1):797.

  24. Wang Q, Chen Q, Zhang Y, Zhang X, Liu C, Wang D, Wu Y, Sun Y, Zhang L, SongC, Wang Y, An Y, Tang H, Xu C, Wu Y, Jin L, Huang H, Zhang F. HSD17B12 dosageinsufficiency induced premature ovarian insufficiency in humans and mice. ClinTransl Med. 2022 Feb;12(2):e737.

  25. Cheng X, Ji X, Yang D, et al. Associations of PM2.5 exposure with blood glucose impairment in early pregnancy and gestational diabetes mellitus. Ecotoxicol Environ Saf. 2022;232:113278.

  26. Lin H, Zhao Y, Zhu Y, et al. Maternal High-Fat Diet Aggravates Allergic Asthma in Offspring via Modulating CD4+ T-Cell Differentiation. Nutrients. 2022;14(12):2508. Published 2022 Jun 16.

  27. Wu D, Zhang J, Xiong Y, Wang H, Lu D, Guo M, Zhang J, Chen L, Fan J, HuangH, Lin X. Effect of Maternal Glucose and Triglyceride Levels during EarlyPregnancy on Pregnancy Outcomes: A Retrospective Cohort Study. Nutrients. 2022Aug 11;14(16):3295.

  28. Luo SS, Zou KX, Zhu H, Cheng Y, Yan YS, Sheng JZ, Huang HF, Ding GL.Integrated Multi-Omics Analysis Reveals the Effect of Maternal GestationalDiabetes on Fetal Mouse Hippocampi. Front Cell Dev Biol. 2022 Feb 14;10:748862.

  29. Pan J, Li J, Chen S, Xu C, Huang H, Jin L. Living birth followingpreimplantation genetic testing for monogenic disorders to prevent low-levelgermline mosaicism related Nicolaides-Baraitser syndrome. Front Genet. 2022 Sep9;13:989041.

  30. Chenming Xu#, Jianli Li#, Songchang Chen#, Xiaoqiang Cai#, Ruilin Jing, Xiaomei Qin, Dong Pan, Xin Zhao, Dongyang Ma, Xiufeng Xu, Xiaojun Liu, Can Wang, Bingxin Yang, Lanlan Zhang, Shuyuan Li, Yiyao Chen, Nina Pan, Ping Tang, Jieping Song, Nian Liu, Chen Zhang, Zhiwei Zhang, Xiang Qiu, Weiliang Lu, Chunmei Ying, Xiaotian Li, Congjian Xu, Yanlin Wang, Yanting Wu*, He-Feng Huang*, Jinglan Zhang*. (2022). Genetic deconvolution of fetal and maternal cell-free DNA in maternal plasma enables next-generation non-invasive prenatal screening. Cell discovery, 8(1), 109.


  1. Yimin Zhou#, Neng Jin#, Qinqing Chen, Min Lv, Ying Jiang, Yuan Chen, Fangfang Xi, Mengmeng Yang, Baihui Zhao, Hefeng Huang*,  Qiong Luo*. Predictive value of cervical length by ultrasound and cervical strain elastography in labor induction at term. Journal of International Medical Research. 2021;49(2). PMID: 33001854.

  2. Jiping Zhang#, Wenjing Hu, Shuyuan Li, Yaofeng Wen, Yong Bao, Hefeng Huang, Chenming Xu*, Dahong Qian*. Chromosome Classification and Straightening Based on an Interleaved and Multi-Task Network. Ieee Journal of Biomedical and Health Informatics. 2021;25(8):3240-51.PMID: 33630742.

  3. Zuwei Yang#, Wenzhong Zhou#, Chengliang Zhou#, Yuzhong Zhou, Xinmei Liu, Guolian Ding, Yulian Hu, Jiexue Pan, Jianzhong Sheng, Li Jin*, Hefeng Huang*. Steroid metabolome profiling of follicular fluid in normo- and hyperandrogenic women with polycystic ovary syndrome. Journal of Steroid Biochemistry and Molecular Biology. 2021;206. PMID: 33340681.

  4. Yi-Shang Yan#, Zihao Qu#, Dan-Qing Yu, Wei Wang, Shigui Yan*, He-Feng Huang*. Sex Steroids and Osteoarthritis: A Mendelian Randomization Study. Frontiers in Endocrinology. 2021;12. PMID: 34248845.

  5. Rui-Hong Xue#, Dan-Dan Wu#, Cheng-Liang Zhou, Lei Chen, Juan Li, Zheng-Zheng Li, Jian-Xia Fan, Xin-Mei Liu, Xian-Hua Lin*, He-Feng Huang, FRCOG*. Association of high maternal triglyceride levels early and late in pregnancy with adverse outcomes: A retrospective cohort study. Journal of Clinical Lipidology. 2021;15(1):162-72. PMID: 33144084.

  6. Rui-Hong Xue# & He-Feng Huang*. Comment on: "A two-third majority of infertile women exhibit endometriosis in pre-ART diagnostic hysteroscopy and laparoscopic chromopertubation: only one-third have a tubal obstruction". Archives of Gynecology and Obstetrics. 2021;303(5):1373-4. PMID: 32653950.

  7. Yan-Ting Wu#, Chen-Jie Zhang#, Ben Willem Mol, Andrew Kawai, Cheng Li, Lei Chen, Yu Wang, Jian-Zhong Sheng, Jian-Xia Fan, Yi Shi*, He-Feng Huang*. Early Prediction of Gestational Diabetes Mellitus in the Chinese Population via Advanced Machine Learning. Journal of Clinical Endocrinology & Metabolism. 2021;106(3):E1191-E205. PMID: 33351102.

  8. Yanting Wu#Isabelle Marc#Luigi BouchardFengxiu OuyangZhong-Cheng LuoJianxia FanLise DuboisBenoît MâsseJun ZhangPeter C K LeungXiang Peng LiaoC M HerbaLinda BooijJian ShenAntoine LewinHong JiangLiping WangJian XuWeibin WuWenguang SunJiahao WuHong LiChen LeiAnita KozyrskyjSonia SemenicN ChailletIsabel FortierLouise MasseJanelle ZhanCatherine AllardBartha KnoppersMa'n ZawatiJean-Patrice BaillargeonMaria P VelezHanqiu ZhangYamei YuWen YuYan DingCaroline VaillancourtHan LiuAmelie TetuWenli FangRong ZhangXinzhi ZhaoYan JinXin-Mei LiuHuijuan ZhangZhirou ChenXi YangYan-Hui HaoNadia AbdelouahabWilliam Fraser*, He-Feng Huang*. Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI): a multicentre, cluster-randomised, parallel-group, superiority trial of a multifaceted community-family-mother-child intervention to prevent childhood overweight and obesity. BMJ Open. 2021;11(4). PMID: 33795307.

  9. Yanting Wu#, Xiaoying Ma#, William D Fraser, Mu Li, Wei Wang, Hefeng Huang, Myriam Landry, Yanhui Hao, Han Liu, Sonia Semenic, Yan Zhang, Haiqin Wang, Jingya Zhang, Jiale Yu, Xuena La, Congcong Zhang, Isabelle Marc*, Hong Jiang*. Caregivers' perceptions, challenges and service needs related to tackling childhood overweight and obesity: a qualitative study in three districts of Shanghai, China. BMC Public Health. 2021;21(1). PMID: 33882878.

  10. Hai-Yan Wu#, Yi Cheng, Lu-Yang Jin, Yin Zhou, Hai-Yan Pang, Hong Zhu, Cao-Chong Yan, Yi-Shang Yan, Jia-En Yu, Jian-Zhong Sheng, He-Feng Huang*. Paternal obesity impairs hepatic gluconeogenesis of offspring by altering Igf2/H19 DNA methylation. Molecular and Cellular Endocrinology. 2021;529. PMID: 33811969.

  11. Yinyu Wang#, Yiting Mao#, Yiran Zhao, Xianfu Yi, Guolian Ding, Chuanjin Yu, Jianzhong Sheng, Xinmei Liu, Yicong Meng* and Hefeng Huang*. Early-life undernutrition induces enhancer RNA remodeling in mice liver. Epigenetics & Chromatin. 2021;14(1). PMID: 33789751.

  12. Huihui Wang#, Chengliang Zhou#, Min Hou, Hefeng Huang*, Yun Sun*. Neurogenesis Potential Evaluation and Transcriptome Analysis of Fetal Hypothalamic Neural Stem/Progenitor Cells With Prenatal High Estradiol Exposure. Frontiers in Genetics. 2021;12. PMID: 34239542.

  13. Yaoyao Tu#, Guangyong Zheng#, Guolian Ding, Yanting Wu, Ji Xi, Yingzhou Ge , Hangchao Gu, Yingyu Wang, Jianzhong Sheng, Xinmei Liu*, Li Jin* and Hefeng Huang*. Comparative Analysis of Lower Genital Tract Microbiome Between PCOS and Healthy Women (vol 11, 1108, 2020). Frontiers in Physiology. 2021;11. PMID: 33013474.

  14. Chang-Fa Sun#, Han Liu, Yan-Hui Hao, Hong-Tao Hu, Zhi-Yang Zhou, Ke-Xin Zou, Xin-Mei Liu, Jian-Zhong Sheng, Guo-Lian Ding, He-Feng Huang*. Association between gestational anemia in different trimesters and neonatal outcomes: a retrospective longitudinal cohort study. World Journal of Pediatrics. 2021;17(2):197-204. PMID: 33625695.

  15. Wei-Hui Shi#, Mu-Jin Ye#,Song-Chang Chen, Jun-Yu Zhang, Yi-Yao Chen, Zhi-Yang Zhou, Ning-Xin Qin, Xuan-You Zhou, Nai-Xin Xu, Zi-Ru Jiang, Jing Lin, He-Feng Huangand Chen-Ming Xu*. Case Report: Preimplantation Genetic Testing and Pregnancy Outcomes in Women With Alport Syndrome. Frontiers in Genetics. 2021;12. PMID: 33633790.

  16. Ningxin Qin#, Zhiyang Zhou#, Wenlong Zhao#, Kexin Zou, Weihui Shi, Chuanjin Yu, Xia Liu, Zehan Dong, Yiting Mao, Xinmei Liu, Jianzhong Sheng, Guolian Ding, Yanting Wu* and Hefeng Huang*. Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer. Frontiers in Cell and Developmental Biology. 2021;9. PMID: 33634140.

  17. Haiyan Pang#, Dandan Ling#, Yi Cheng, Rubab Akbar, Luyang Jin, Jun Ren, Haiyan Wu, Bin Chen, Yin Zhou, Hong Zhu, Yuzhong Zhou, Hefeng Huang*, Jianzhong Sheng*. Gestational high-fat diet impaired demethylation of Ppar alpha and induced obesity of offspring. Journal of Cellular and Molecular Medicine. 2021;25(12):5404-16. PMID: 33955677.

  18. Jiexue Pan#, Chengliang Zhou, Zhiyang Zhou, Zuwei Yang, Tiantian Dai, Hefeng Huang*, Li Jin*. Elevated ovarian pentraxin 3 in polycystic ovary syndrome. Journal of Assisted Reproduction and Genetics. 2021;38(5):1231-7. PMID: 33594624.

  19. Yiting Mao#, Chen Zhang#, Yinyu Wang, Yicong Meng, Lei Chen, Cindy-Lee Dennis, Jianzhong Sheng, Yanting Wu* and Hefeng Huang*. Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study. Frontiers in Endocrinology. 2021;12.PMID: 34367073.

  20. Ye Liu#, Xinzhu Li#, Songchang Chen, Li Wang, Yajing Tan, Xiaocui Li, Lin Tang, Junyu Zhang, Dandan Wu, Yanting Wu, Xinmei Liu, Yimin Zhu, Jianzhong Sheng, Jiexue Pan*, Li Jin* and Hefeng Huang*. Comparison of Genome-Wide DNA Methylation Profiles of Human Fetal Tissues Conceived by in vitro Fertilization and Natural Conception. Frontiers in Cell and Developmental Biology. 2021;9. PMID: 34336842.

  21. Han Liu#, Hong Li, Cheng Li, Lei Chen, Chenjie Zhang, Zhiwei Liu, Yanting Wu*, Hefeng Huang*. Associations between Maternal Sleep Quality Throughout Pregnancy and Newborn Birth Weight. Behavioral Sleep Medicine. 2021;19(1):57-69.PMID: 31830816.

  22. Xian-Hua Lin#, Ling Gao, Shen Tian, Christian Klausen, Meng-Xi Guo, Qian Gao, Miao-E Liu, Hui Wang, Dan-Dan Wu, Cheng-Liang Zhou, Jing Yang, Ye Meng, Ye Liu, Gu-Feng Xu, Ya-Jing Tan, Kamran Ullah, Yi-Min Zhu, William D Fraser, Jian-Zhong Sheng, Peter C K Leung, Louis J Muglia, Yan-Ting Wu*, He-Feng Huang*. Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring. Scientific Reports. 2021;11(1). PMID: 33431976.

  23. Yinlam Li#, Li Zhang#, Xiaoguo Zheng, Jianing Qian, Yanquan Li, Chong Xie, Xuelian Zhang*, Yuchuan Zhou*, Hefeng Huang*. Dietary restriction and/or exercise training impairs spermatogenesis in normal rats. Applied Physiology Nutrition and Metabolism. 2021;46(3):229-37.PMID: 32905708.

  24. Jing-Yi Li#, Yan-Yun Ying#, Yu-Li Qian, Jian-Peng Chen, Yun Huang, Juan Liu, Ping-Ping Lv, Yi-Feng Liu, Xiao-Ling Hu, Samantha L P Schilit, Jian-Zhong Sheng, He-Feng Huang*, Dan Zhang*. BNC1 Promotes Spermatogenesis by Regulating Transcription of Ybx2 and Papolb via Direct Binding to Their Promotor Elements. Reproductive Sciences. 2021;28(3):785-93. PMID: 33211273.

  25. Cheng Li#, Jing-Jing Xu#, Hong-Tao Hu, Chao-Yi Shi, Chuan-Jin Yu, Jian-Zhong Sheng, Yan-Ting Wu*, He-Feng Huang*. Amylin receptor insensitivity impairs hypothalamic POMC neuron differentiation in the male offspring of maternal high-fat diet-fed mice. Molecular Metabolism. 2021;44. PMID: 33279727.

  26. Cheng Li#, Jing-Jing Xu#, Yi-Chen He, Lei Chen, Cindy-Lee Dennis, He-Feng Huang, Yan-Ting Wu*. Effects of acute ambient pollution exposure on preterm prelabor rupture of membranes: A time-series analysis in Shanghai, China. Environmental Pollution. 2021;276. PMID: 33662814.

  27. Cheng Li#, Yi-Chen He#, Jing-Jing Xu#, Yu Wang, Han Liu, Chen-Chi Duan, Chao-Yi Shi, Lei Chen, Jie Wang, Jian-Zhong Sheng, He-Feng Huang* and Yan-Ting Wu* . Perinatal outcomes of neonates born from different endometrial preparation protocols after frozen embryo transfer: a retrospective cohort study. Bmc Pregnancy and Childbirth. 2021;21(1). PMID: 33926401.

  28. Luyang Jin#, Jia’en Yu#, Yuxiao Chen, Haiyan Pang, Jianzhong Sheng* and Hefeng Huang*. Polycystic Ovary Syndrome and Risk of Five Common Psychiatric Disorders Among European Women: A Two-Sample Mendelian Randomization Study. Frontiers in Genetics. 2021;12. PMID: 34211505.

  29. Ziru Jiang#, Kexin Zou#, Xia Liu, Hangchao Gu, Yicong Meng, Jing Lin, Weihui Shi, Chuanjin Yu, Li Jin, Li Wang, Xinmei Liu, Jianzhong Sheng, Hefeng Huang*, Guolian Ding*. Aging attenuates the ovarian circadian rhythm. Journal of Assisted Reproduction and Genetics. 2021;38(1):33-40. PMID: 32926298.

  30. Yingzhou Ge#, Chen Zhang, Yanqing Cai*, Hefeng Huang*. Adverse Maternal and Neonatal Outcomes in Women With Elevated Intrapartum Temperature Complicated by Histological Chorioamnionitis at Term: A Propensity-Score Matched Study. Frontiers in Pediatrics. 2021;9. PMID: 34368025.

  31. Ying-Zhou Ge#, Chen Zhang, Yan-Qing Cai*, He-Feng Huang*. Application of the RCOG Risk Assessment Model for Evaluating Postpartum Venous Thromboembolism in Chinese Women: A Case-Control Study. Medical Science Monitor. 2021;27. PMID: 34230447.

  32. Yingjie Chen#, Wenwen Chen*, Huanfang Huang, Honghu Zeng, Lingzhi Tan, Yu Pang, Junaid Ghani, Shihua Qi*. Occurrence of N-nitrosamines and their precursors in the middle and lower reaches of Yangtze River water. Environmental Research. 2021;195. PMID: 33508261.

  33. Songchang Chen#, Lanlan Zhang#, Jiong Gao, Shuyuan Li, Chunxin Chang, Yiyao Chen, Hongjun Fei, Junyu Zhang, Yanlin Wang, Hefeng Huang, Chenming Xu* and Daru Lu*. Expanding the Scope of Non-invasive Prenatal Testing to Detect Fetal Chromosomal Copy Number Variations. Frontiers in Molecular Biosciences. 2021;8. PMID: 33508261.

  34. Luting Chen#, Huixi Chen#, Xiaojin Wang, Bing Wei, Zhengmu Wu, Songchang Chen, Bingshun Wang, Hefeng Huang*, Li Jin*. Association of homocysteine with IVF/ ICSI outcomes stratified by MTHFR C677T polymorphisms: a prospective cohort study. Reproductive Biomedicine Online. 2021;43(1):52-61. PMID: 34016520.

  35. Huixi Chen#, Silvia Vannuccini#, Tommaso Capezzuoli, Marcello Ceccaroni, Liu Mubiao, Huang Shuting, Yanting Wu, Hefeng Huang, Felice Petraglia*. Comorbidities and Quality of Life in Women Undergoing First Surgery for Endometriosis: Differences Between Chinese and Italian Population. Reproductive Sciences. 2021;28(8):2359-66. PMID: 33751460.

  36. Nina Pan#, Songchang Chen, Xiaoqiang Cai, Jianli Li, Tao Yu, He-Feng Huang, Jinglan Zhang, Chenming Xu*. Low-level germline mosaicism of a novel SMARCA2 missense variant: Expanding the phenotypic spectrum and mode of genetic transmission.Molecular Genetics & Genomic Medicine. 2021 Jul 22:e1763. PMID: 34296532.

  37. Yanting Wu#, Chenjie Zhang, Hefeng Huang*. Authors' reply re: Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. BJOG. 2021 Sep;128(10):1711-1712. Epub 2021 Jun 10. PMID: 34114326.

  38. Rui-Hong Xue#, Juan Li, Lei Chen, Zheng-Zheng Li, Zhen Huang, He-Feng Huang*, Xian-Hua Lin*. Alternations of cesarean section rates in a non-infected population after the outbreak of COVID-19: a cross-sectional study. Psychol Health Med. 2021 Mar 15:1-7. doi: 10.1080/13548506.2021.1893768. Epub ahead of print. PMID: 33715523.


  1. Cheng-Liang Zhou#, Gu-Feng Xu, Qian Yang, Hui-Hui Wang, Meng-Xi Guo, Yi-Meng Xiong, Xiao-Yan Guo, Min Hou, Lu-Yang Jin, Jian-Zhong Sheng, Lin He, Li Jin*, He-Feng Huang*. Diminished verbal ability among children conceived through ART with exposure to high serum estradiol in utero. Journal of Assisted Reproduction and Genetics. 2020;37(8):1931-8. PMID: 32519010.

  2. Huan Zhao#, Yan Li, Lingjuan He, Wenjuan Pu, Wei Yu, Yi Li, Yan-Ting Wu, Chenming Xu, Yuda Wei, Qiurong Ding, Bao-Liang Song, Hefeng Huang, Bin Zhou*. In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia. Circulation. 2020;141(1):67-79. PMID: 31779484.

  3. Yu Zhang#, Chao Zhang#, Jing Shu, Jing Guo, Hsun-Ming Chang, Peter C K Leung*, Jian-Zhong Sheng, Hefeng Huang*. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Human Reproduction Update. 2020;26(2):247-63. PMID: 32045470.

  4. Chuan-Jin Yu#, Xia Liu#, Zhi-Yang Zhou, Xiao-Jun Chen, Yi-Cong Meng, Hang-Chao Gu, Jing-Jing Xu, Guo-Lian Ding, Xin-Mei Liu*, Jian-Zhong Sheng*, He-Feng Huang*. The casein kinase 2 alpha promotes the occurrence polycystic ovary syndrome. Biochemical and Biophysical Research Communications. 2020;525(1):121-8. PMID: 32081430.

  5. Xi Yang#, Yamei Yu#, Chen Zhang, Yong Zhang, Zhirou Chen, Lise Dubois, He-Feng Huang*, William D Fraser*, Jianxia Fan*. The Association Between Isolated Maternal Hypothyroxinemia in Early Pregnancy and Preterm Birth. Thyroid. 2020;30(12):1724-31. PMID: 32434441.

  6. Caochong Yan#Yunxiang Zhou#*, Qiang ChenYi LuoJohn H Zhang*, Hefeng Huang*, Anwen Shao*. Dysfunction of the neurovascular unit in diabetes-related neurodegeneration. Biomedicine & Pharmacotherapy. 2020;131. PMID: 32841897.

  7. Rui-Hong Xue#, Xian-Hua Lin, Dan-Dan Wu, He-Feng Huang*. Monitoring maternal triglyceride concentrations during pregnancy could be useful in reducing perinatal mortality. Acta Obstetricia Et Gynecologica Scandinavica. 2020;99(9):1262. PMID: 32232828.

  8. Rui-Hong Xue#, Juan Li#, Zhen Huang, Zheng-Zheng Li, Lei Chen, Qin Lin, He-Feng Huang*. Is tubal endometriosis an asymmetric disease? A 17-year retrospective study. Archives of Gynecology and Obstetrics. 2020;301(3):721-7. PMID: 32114673.

  9. Yanting Wu#, Chen Zhang, Han Liu, Chenchi Duan, Cheng Li, Jianxia Fan, Hong Li, Lei Chen, Hualin Xu, Xiangjuan Li, Yi Guo, Yeping Wang, Xiufeng Li, Jing Li, Ting Zhang, Yiping You, Hongmei Li, Shuangqi Yang, Xiaoling Tao, Yajuan Xu, Haihong Lao, Ming Wen, Yan Zhou, Junying Wang, Yuhua Chen, Diyun Meng, Jingli Zhai, Youchun Ye, Qinwen Zhong, Xiuping Yang, Dan Zhang, Jing Zhang, Xifeng Wu, Wei Chen, Cindy-Lee Dennis, He-Feng Huang*. Perinatal depressive and anxiety symptoms of pregnant women during the coronavirus disease 2019 outbreak in China. American Journal of Obstetrics and Gynecology. 2020;223(2). PMID: 32437665.

  10. Yan-Ting Wu#, Jun Liu#, Jing-Jing Xu#, Yan-Fen Chen#, Wen Yang, Yang Chen, Cheng Li, Yu Wang, Han Liu, Chen Zhang, Ling Jiang, Zhao-Xia Qian, Andrew Kawai, Ben Willem Mol, Cindy-Lee Dennis, Guo-Ping Xiong*, Bi-Heng Cheng*, Jing Yang*, He-Feng Huang*. Neonatal outcome in 29 pregnant women with COVID-19: A retrospective study in Wuhan, China. Plos Medicine. 2020;17(7). PMID: 32722722.

  11. Yan-Ting Wu#, Cheng Li, Chen-Jie Zhang, He-Feng Huang*, FRCOG. Is termination of early pregnancy indicated in women with COVID-19? European Journal of Obstetrics & Gynecology and Reproductive Biology. 2020;251:271-2. PMID: 32456886.

  12. Yan-Ting Wu#, Ze-Han Dong#, Cheng Li#, Dai-Zhan Zhou, Jun-Yu Zhang, Yan Wu, Jing-Jing Xu, Yu Wang, Xiao-Qun Ye, Jian-Zhong Sheng , Li Wang, He-Feng Huang*. The effect of blastomere loss during frozen embryo transfer on the transcriptome of offspring's umbilical cord blood. Molecular Biology Reports. 2020;47(11):8407-17. PMID: 33068229.

  13. Dan-dan Wu#, Ling Gao#, Ou Huang#, Kamran Ullah, Meng-xi Guo, Ye Liu, Jian Zhang, Lei Chen, Jian-xia Fan, Jian-zhong Sheng, Xian-hua Lin, He-feng Huang*. Increased Adverse Pregnancy Outcomes Associated With Stage 1 Hypertension in a Low-Risk Cohort Evidence From 47 874 Cases. Hypertension. 2020;75(3):772-80. PMID: 32008433.

  14. Lu Wen#, Qiang Liu, Jingjing Xu, Xixi Liu, Chaoyi Shi, Zuwei Yang, Yili Zhang, Hong Xu, Jiang Liu*, Hui Yang*, Hefeng Huang*, Jie Qiao*, Fuchou Tang* & Zi-Jiang Chen*. Recent advances in mammalian reproductive biology. Science China-Life Sciences. 2020;63(1):18-58. PMID: 31813094.

  15. Yaoyao Tu#, Guangyong Zheng#, Guolian Ding, Yanting Wu, Ji Xi, Yingzhou Ge, Hangchao Gu, Yingyu Wang, Jianzhong Sheng, Xinmei Liu*, Li Jin* and Hefeng Huang*. Comparative Analysis of Lower Genital Tract Microbiome Between PCOS and Healthy Women. Frontiers in Physiology. 2020;11. PMID: 33013474.

  16. Xia Liu#, Changfa Sun#, Kexin Zou, Cheng Li, Xiaojun Chen, Hangchao Gu, Zhiyang Zhou, Zuwei Yang, Yaoyao Tu, Ningxin Qin, Yiran Zhao, Yimei Wu, Yicong Meng, Guolian Ding, Xinmei Liu*, Jianzhong Sheng, Chuanjin Yu*, Hefeng Huang*. Novel PGK1 determines SKP2-dependent AR stability and reprograms granular cell glucose metabolism facilitating ovulation dysfunction. Ebiomedicine. 2020;61. PMID: 33096483.

  17. Ting-Ting Lin#, Chen Zhang#, Han-Qiu Zhang, Yu Wang, Lei Chen, Cindy-Lee Dennis, Hefeng Huang* and Yan-Ting Wu*. Thyroid Hormone Changes in Early Pregnancy Along With the COVID-19 Pandemic. Frontiers in Endocrinology. 2020;11.PMID: 33365014.

  18. Jing Lin#, Han Liu#, Dan-Dan Wu, Hong-Tao Hu, Hui-Hui Wang, Cheng-Liang Zhou, Xin-Mei Liu, Xiao-Jun Chen, Jian-Zhong Sheng & He-Feng Huang*. Long interpregnancy interval and adverse perinatal outcomes: A retrospective cohort study. Science China-Life Sciences. 2020;63(6):898-904. PMID: 31701403.

  19. Tong Li#Xinzhu LiYanyan GuoGuangyong ZhengTiantian YuWeihong ZengLin QiuXiaoying HeYu YangXiaoguo ZhengYuchen LiHefeng Huang*, Xinmei Liu*. Distinct mRNA and long non-coding RNA expression profiles of decidual natural killer cells in patients with early missed abortion. Faseb Journal. 2020;34(11):14264-86. PMID: 32915478.

  20. Jing-Yi Li#, Yi-Feng Liu#, Hai-Yan Xu, Jun-Yu Zhang, Ping-Ping Lv, Miao-E Liu, Yan-Yun Ying, Ye-Qing Qian, Kun Li, Cheng Li, Yun Huang, Gu-Feng Xu, Guo-Lian Ding, Yu-Chan Mao, Chen-Ming Xu, Xin-Mei Liu, Jian-Zhong Sheng, Dan Zhang*, and He-Feng Huang*. Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis. Journal of Molecular Cell Biology. 2020;12(1):71-83. PMID: 31065688.

  21. Cheng Li#, Yun-Fei Su#, Li Jin, Yan-Yan Guo, Guo-Lian Ding, Lin Tang, Mei Cai, He-Feng Huang*, Xin-Mei Liu*. Association between higher levels of serum estradiol and elevated levels of fibrin (fibrinogen) degradation products in late pregnancy following assisted reproductive technology treatment. Thrombosis Research. 2020;187:63-71. PMID: 31958688.

  22. Jing-Jing Xu# , Lei Chen#, Cheng Li, Chen-Chi Duan, He-Feng Huang* and Yan-Ting Wu*. Effect of embryo cryopreservation duration on pregnancy-related complications and birthweight after frozen-thawed embryo transfer: a retrospective cohort study. Human Reproduction. 2020;35:1495. PMID: 33947503.

  23. Yan-Yan Guo#, Tong Li, Han Liu, Lin Tang, Yu-Chen Li, Hong-Tao Hu, Yun-Fei Su, Yu Lin, Yin-Yu Wang, Cheng Li, He-Feng Huang, Li Jin, Xin-Mei Liu*. Circulating levels of Elabela and Apelin in the second and third trimesters of pregnancies with gestational diabetes mellitus. Gynecological Endocrinology. 2020;36(10):890-4. PMID: 32208782.

  24. Mengxi Guo#, Chengliang Zhou, Gufeng Xu, Lin Tang, Yechun Ruan, Ying Yu, Xianhua Lin, Dandan Wu, Hao Chen, Priscilla Yu, Luyang Jin, Yinyu Wang, Yimei Wu, Kamran Ullah, Tanzil Ur Rahman, Xinmei Liu, Jianzhong Sheng, Hsiao-Chang Chan*, Hefeng Huang*. An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction. Science China-Life Sciences. 2020;63(3):388-400. PMID: 31197761.

  25. WeiGu#,JingLin, Yan-YanHou, NanLin, Meng-FanSong, Wei-JianZeng, JingShang, He-FengHuang*. Effects of low-dose aspirin on the prevention of preeclampsia and pregnancy outcomes: A randomized controlled trial from Shanghai, China. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2020;248:156-63. PMID: 32217429.

  26. Ling Gao#, Dandan Wu#, Yanting Wu, Zuwei Yang, Jianzhong Sheng, Xianhua Lin*, Hefeng Huang*. MiR-3940-5p promotes granulosa cell proliferation through targeting KCNA5 in polycystic ovarian syndrome. Biochemical and Biophysical Research Communications. 2020;524(4):791-7. PMID: 32019676.

  27. Chen-Chi Duan#, Cheng Li#, Yi-Chen He, Jing-Jing Xu, Chao-Yi Shi, Hong-Tao Hu, Yun-Fei Su, Lei Chen, Ya-Jing Tan, Zhi-Wei Liu, Jian-Zhong Sheng, William D. Fraser, Yan-Ting Wu* and He-Feng Huang*. Oocyte exposure to supraphysiological estradiol during ovarian stimulation increased the risk of adverse perinatal outcomes after frozen-thawed embryo transfer: a retrospective cohort study. Journal of Developmental Origins of Health and Disease. 2020;11(4):392-402. PMID: 31679538.

  28. Songchang Chen#, Weihui Shi#, Yeqing Qian, Liya Wang, Junyu Zhang, Shuyuan Li, Yiyao Chen, Chunxin Chang, Hongjun Fei, Lanlan Zhang, Hefeng Huang, Chenming Xu*. Preimplantation Genetic Testing for a Chinese Family With X-Linked Lymphoproliferative Syndrome Type 1. Frontiers in Genetics. 2020;11. PMID: 33329693.

  29. Luting Chen#, Huixi Chen, Xinmei Liu, Jingyi Li, Qian Gao, Shuai Shi, Tingting Wang, Xiaoqun YeYongchao Lu, Dan Zhang, Jianzhong Sheng, Li Jin*, Hefeng Huang*. AQP7 mediates post-menopausal lipogenesis in adipocytes through FSH-induced transcriptional crosstalk with AP-1 sites. Reproductive Biomedicine Online. 2020;41(6):1122-32. PMID: 33132060.

  30. Huixi Chen#, Francesca Malentacchi, Massimiliano Fambrini, Abdel Halim Harrath, Hefeng Huang, Felice Petraglia*. Epigenetics of Estrogen and Progesterone Receptors in Endometriosis. Reproductive Sciences. 2020;27(11):1967-74. PMID: 32700282.

  31. Rubab Akbar#, Kamran Ullah#, Tanzil Ur Rahman, Yi Cheng, Hai-Yan Pang, Lu-Yang Jin, Qi-Jing Wang, He-Feng Huang*, Jian-Zhong Sheng*. miR-183-5p regulates uterine receptivity and enhances embryo implantation. Journal of Molecular Endocrinology. 2020;64(1):43-52.PMID: 31786540.

  32. Chen-Chi Duan#, Cheng Li#, Yi-Chen He, Jing-Jing Xu, Chao-Yi Shi, Hong-Tao Hu, Yun-Fei Su, Lei Chen, Ya-Jing Tan, Zhi-Wei Liu, Jian-Zhong Sheng, William D. Fraser, Yan-Ting Wu*, and He-Feng Huang*. Oocyte exposure to supraphysiological oestradiol during ovarian stimulation increased the risk of adverse perinatal outcomes after frozen-thawed embryo transfer: a retrospective cohort study.  Journal of developmental origins of health and disease. 2020 Aug;11(4):392-402. PMID: 31679538.


  1. Kexin Zou#, Guolian Ding* & Hefeng Huang*. Advances in research into gamete and embryo-fetal origins of adult diseases. Science China-Life Sciences. 2019;62(3):360-8. PMID: 30685828.

  2. Hong Zhu#, Bin Chen#, Yi Cheng, Yin Zhou, Yi-Shang Yan, Qiong Luo, Ying Jiang, Jian-Zhong Sheng, Guo-Lian Ding*, He-Feng Huang*. Insulin Therapy for Gestational Diabetes Mellitus Does Not Fully Protect Offspring From Diet-Induced Metabolic Disorders. Diabetes. 2019;68(4):696-708. PMID: 30696708.

  3. Danni Zheng#, Lin Zeng#, Rui Yang#, Ying Lian, Yi-Min Zhu, Xiaoyan Liang, Li Tang, Huichun Wang, Yunxia Cao, Guimin Hao, Jianqiao Liu, Junli Zhao, Rui Wang, Ben Willem Mol, Rong Li, He-Feng Huang*, Jie Qiao*. Intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilisation (IVF) in couples with non-severe male infertility (NSMI-ICSI): protocol for a multicentre randomised controlled trial. Bmj Open. 2019;9(9). PMID: 31575574.

  4. Yong Zhang#, Chen Zhang#, Xi Yang, Shuai Yang, Yu Meng, Zhiwei Liu, Robin P. Peeters, He-Feng Huang*, Tim I. M. Korevaar*, Jianxia Fan*. Association of Maternal Thyroid Function and Thyroidal Response to Human Chorionic Gonadotropin with Early Fetal Growth. Thyroid. 2019;29(4):586-94. PMID: 30803392.

  5. Xue-Ying Zhang#, Yi-Meng Xiong#, Ya-Jing Tan, Li Wang, Rong Li, Yong Zhang, Xin-Mei Liu, Xian-Hua Lin, Li Jin, Yu-Ting Hu, Zhen-Hua Tang, Zheng-Mu Wu, Feng-Hua Yin, Zheng-Quan Wang, Ye Xiao, Jian-Zhong Sheng, He-Feng Huang*. Melatonin rescues impaired penetration ability of human spermatozoa induced by mitochondrial dysfunction. Reproduction. 2019;158(5):465-75. PMID: 31505459.

  6. Qianqian Zhang#, Hao Chen, Yi Wang, Chen Zhang, Zhen Tang, Hong Li, Xiaoyi Huang, Fengxiu Ouyang, Hefeng Huang*, Zhiwei Liu*. Severe vitamin D deficiency in the first trimester is associated with placental inflammation in high-risk singleton pregnancy. Clinical Nutrition. 2019;38(4):1921-6. PMID: 30031659.

  7. Chen Zhang#,Xi Yang,Yong Zhang,Fei Guo, Shuai Yang,Robin P. Peeters, Tim I. M. Korevaar,Jianxia Fan* and He-Feng Huang*. Association Between Maternal Thyroid Hormones and Birth Weight at Early and Late Pregnancy. Journal of Clinical Endocrinology & Metabolism. 2019;104(12):5853-63. PMID: 31216012.

  8. Tiantian Yu#, Chun Feng#, Pingping Lv, Gufeng Xu, Lihua Hong, Yimeng Xiong, Xiaoyan Guo, Tong Li, Jianzhong Sheng, Hefeng Huang* & Xinmei Liu*. Decreased decidual epithelial sodium channel (ENaC) alpha and gamma subunits in recurrent pregnancy loss (RPL). Science China-Life Sciences. 2019;62(7):988-90. PMID: 30810965.

  9. Dan-Qing Yu#,Ping-Ping Lv,Yi-Shang Yan, Guan-Xin Xu,Annapurna Sadhukhan, Shan Dong, Yan Shen, Jun Ren, Xue-Ying Zhang, Chun Feng, Yi-Ting Huang, Shen Tian, Yin Zhou,Yi-Ting Cai, Zhen-Hua Ming, Guo-Lian Ding, Hong Zhu, Jian-Zhong Sheng, Min Jin*, and He-Feng Huang*. Intrauterine exposure to hyperglycemia retards the development of brown adipose tissue. Faseb Journal. 2019;33(4):5425-39. PMID: 30759346.

  10. Yuqian Xiang#, Yabing Sun, Bingxin Yang, Yeping Yang, Ying Zhang, Tiantian Yu, Hefeng Huang, Junyu Zhang*, Hong Xu*. Transcriptome sequencing of adenomyosis eutopic endometrium: A new insight into its pathophysiology. Journal of Cellular and Molecular Medicine. 2019;23(12):8381-91. PMID: 31576674.

  11. Yin-Yu Wang#, Ye Liu, Cheng Li, Jing Lin, Xin-Mei Liu, Jian-Zhong Sheng & He-Feng Huang*. Frequency and risk factors for recurrent gestational diabetes mellitus in primiparous women: a case control study. Bmc Endocrine Disorders. 2019;19. PMID: 30767767.

  12. Ye Liu#, Yinyu Wang#, Fangfang Wang, Jiexue Pan, Jingjing Xu, Jingyi Li, Chengliang Zhou, Guolian Ding, Yanting Wu, Xinmei Liu, Jianzhong Sheng & Hefeng Huang*. Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants. Science China-Life Sciences. 2019;62(2):257-67. PMID: 30767767.

  13. Qiaozhen Liu #, Kuo Liu#, Guizhong Cui#, Xiuzhen Huang , Shun Yao, Wenke Guo, Zhen Qin, Yan Li , Rui Yang, Wenjuan Pu , Libo Zhang , Lingjuan He , Huan Zhao, Wei Yu , Muxue Tang, Xueying Tian , Dongqing Cai, Yu Nie , Shengshou Hu, Tao Ren, Zengyong Qiao, Hefeng Huang, Yi Arial Zeng, Naihe Jing , Guangdun Peng *, Hongbin Ji * and Bin Zhou *. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nature Genetics. 2019;51(4):728. PMID: 30778223.

  14. Xian-hua Lin#, Dan-dan Wu#, Cheng Li, Yi-jing Xu, Ling Gao, Geffen Lass, Jian Zhang, Shen Tian, Deyana Ivanova, Lin Tang, Lei Chen, Rong Ding, Xi-mei Liu, Mi Han, Jian-xia Fan, Xiao-feng Li, Jian-zhong Sheng, Kevin T. O’Byrne, and He-feng Huang*. Maternal High Triglyceride Levels During Early Pregnancy and Risk of Preterm Delivery: A Retrospective Cohort Study. Journal of Clinical Endocrinology & Metabolism. 2019;104(4):1249-58. PMID: 30321365.

  15. Xiang-Peng Liao#, Yamei Yu#, Isabelle Marc,Lise Dubois, Nadia Abdelouahab, Luigi Bouchard, Yan-Ting Wu, Fengxiu Ouyang, Heng-Feng Huang, William D Fraser*. Prenatal determinants of childhood obesity: a review of risk factors. Canadian Journal of Physiology and Pharmacology. 2019;97(3):147-54. PMID: 30661367.

  16. Xiang-Juan Li#, Hai-Tao Pan#, Juan-Juan Chen, Yi-Bin Fu, Min Fang, Guo-Hua He, Tao Zhang, Hai-Gang Ding, Bin Yu, Yi Cheng, Ya-Jing Tan, Fa-Lin Zhao, Abraham N. Morse, and He-Feng Huang*. Proteomics of Uterosacral Ligament Connective Tissue from Women with and without Pelvic Organ Prolapse. Proteomics Clinical Applications. 2019;13(4). PMID: 30516354.

  17. Cheng Li#, Yan-Ting Wu#, Qian Zhu, Hui-Yu Zhang, Zhen Huang, Duo Zhang, Hang Qi, Gui-Ling Liang, Xiao-Qing He, Xiao-Feng Wang, Xue Tang, He-Feng Huang* and Jian Zhang*. TRPV4 is involved in levonorgestrel-induced reduction in oviduct ciliary beating. Journal of Pathology. 2019;248(1):77-87. PMID: 30632164.

  18. Ziru Jiang#, Li Jin#, Weihui Shi, Ji Xi, Yulian Hu, Xinmei Liu, Jianzhong Sheng, Guolian Ding* & Hefeng Huang*. A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis. Science China-Life Sciences. 2019;62(1):112-8. PMID: 29980904.

  19. Min Hou#, Hang-Chao Gu#, Hui-Hui Wang, Xin-Mei Liu, Cheng-Liang Zhou, Qian Yang, Zi-Ru Jiang, Jing Lin, Yi-Mei Wu, Yan-Ting Wu, Jian-Zhong Sheng, He-Feng Huang*. Prenatal exposure to testosterone induces cardiac hypertrophy in adult female rats through enhanced Pkc delta expression in cardiac myocytes. Journal of Molecular and Cellular Cardiology. 2019;128:1-10. PMID: 30641088.

  20. X-Y Guo#J ShuX-H FuX-P ChenL ZhangM-X JiX-M LiuT-T YuJ-Z ShengH-F Huang*. Improving the effectiveness of lifestyle interventions for gestational diabetes prevention: a meta-analysis and meta-regression. Bjog-an International Journal of Obstetrics and Gynaecology. 2019;126(3):311-20. PMID: 30216635.

  21. Jianxia Fan#*, Yong Zhang#, Chen Zhang, Mirjana Barjaktarovic, Xi Yang, Robin P Peeters, He-Feng Huang*, Tim I M Korevaar*. Persistency of Thyroid Dysfunction from Early to Late Pregnancy. Thyroid. 2019;29(10):1475-84. PMID: 31347461.

  22. Xi Chen#Hui Lin#Daping YangWei XuGuangwei LiuXinmei Liu*Jianzhong Sheng*Hefeng Huang*. Early-life undernutrition reprograms CD4(+) T-cell glycolysis and epigenetics to facilitate asthma. Journal of Allergy and Clinical Immunology. 2019;143(6):2038. PMID: 30654047.


  1. Yin Zhou#, Hong Zhu, Hai-Yan Wu, Lu-Yang Jin, Bin Chen, Hai-Yan Pang, Zhen-Hua Ming, Yi Cheng, Cheng-Liang Zhou, Meng-Xi Guo, Yi-Ting Huang, Dan-Qing Yu , Jian-Zhong Sheng, He-Feng Huang*. Diet-Induced Paternal Obesity Impairs Cognitive Function in Offspring by Mediating Epigenetic Modifications in Spermatozoa. Obesity. 2018;26(11):1749-57. PMID: 30358144.

  2. Chengliang Zhou#, Ying Yu#, Qian Yang, Huihui Wang, Min Hou, Li Jin, Fanghong Zhang, Jiangzhong Sheng, Mingfang Miao, Xiaofu Yang*, He-Feng Huang*. Motor development delay in offspring is associated with prenatal telbivudine exposure. Medicine. 2018;97(9). PMID: 29489662.

  3. Dan Zhang#*, Yifeng Liu#, Zhou Zhang#, Pingping Lv#, Yun Liu, Jingyi Li, Yiqing Wu, Runjv Zhang, Yun Huang, Gufeng Xu, Yeqing Qian, Yuli Qian, Songchang Chen, Chenming Xu, Jun Shen, Linling Zhu, Kai Chen, Bo Zhu, Xiaoqun Ye, Yuchan Mao, Xingsheng Bo, Caiyun Zhou, Tingting Wang, Dianfu Chen, Weijun Yang, Yajing Tan, Yang Song, Daizhan Zhou, Jianzhong Sheng, Huijuan Gao, Yimin Zhu, Meigen Li, Liping Wu, Lin He, Hefeng Huang*. Basonuclin 1 deficiency is a cause of primary ovarian insufficiency. Human Molecular Genetics. 2018;27(21):3787-800. PMID: 30010909.

  4. Yan-Ting Wu#, Cheng Li#, Yi-Min Zhu, Shu-Hua Zou, Qiong-Fang Wu, Li-Ping Wang, Yan Wu, Rong Yin, Chao-Yi Shi, Jing Lin, Zi-Ru Jiang, Yi-Jing Xu, Yun-Fei Su, Jian Zhang, Jian-Zhong Sheng, William D. Fraser, Zhi-Wei Liu* and He-Feng Huang1,2*. Outcomes of neonates born following transfers of frozen-thawed cleavage-stage embryos with blastomere loss: a prospective, multicenter, cohort study. Bmc Medicine. 2018;16. PMID: 29914496.

  5. Min Wang#*, Zhengmu Wu, Yuting Hu, Yong Wang, Yajing Tan, Yuqian Xiang, Li Wang, Li Jin, Hefeng Huang. An adapted carrier for the cryopreservation of human testicular spermatozoa. Reproductive Biomedicine Online. 2018;37(5):590-9. PMID: 30366839.

  6. Hui-Hui Wang#, Cheng-Liang Zhou#, Min Lv, Qian Yang, Ju-Xue Li, Min Hou, Jing Lin, Xin-Mei Liu, Yan-Ting Wu, Jian-Zhong Sheng, and He-Feng Huang*. Prenatal High Estradiol Exposure Induces Sex-Specific and Dietarily Reversible Insulin Resistance Through Decreased Hypothalamic INSR. Endocrinology. 2018;159(1):465-76. PMID: 29155986.

  7. Xiao Sun#, Jing Hui Guo#, Dan Zhang, Jun-jiang Chen, Wei Yin Lin, Yun Huang, Hui Chen, Wen Qing Huang, Yifeng Liu, Lai Ling Tsang, Mei Kuen Yu, Yiu Wa Chung, Xiaohua Jiang, Hefeng Huang, Hsiao Chang Chan*, & Ye Chun Ruan**. Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. Embo Molecular Medicine. 2018;10(10). PMID: 30154237.

  8. Li-Juan Sun#, Gu-Feng Xu, Min Lv, Hao Zhou, He-Feng Huang, Qiong Luo*. Predictive Value of Maternal Serum Biomarkers for Preeclampsia and Birth Weight: A Case-Control Study in Chinese Pregnant Women. Journal of Womens Health. 2018;27(12):1519-24. PMID: 29920141.

  9. Yiping Shen#*, Xiaoxia Qiu#, Baohen Gui, Sheng He, Hefeng Huang, Jingjie Xue, Xiangming Xu, Xue Zhang, Lin He*. Implementing comprehensive genetic carrier screening in China?Harnessing the power of genomic medicine for the effective prevention/management of birth defects and rare genetic diseases in China. Pediatric Investigation. 2018;2(1):30-6. PMID: 32851227.

  10. Jun Ren#, Yi Cheng#, ZhenHua Ming, XinYan Dong, YuZhong Zhou, GuoLian Ding, HaiYan Pang, Tanzil Ur Rahman, Rubab Akbar, HeFeng Huang* and JianZhong Sheng*. Intrauterine hyperglycemia exposure results in intergenerational inheritance via DNA methylation reprogramming on F1 PGCs. Epigenetics & Chromatin. 2018;11. PMID: 29801514.

  11. Jie-Xue Pan#, Ya-Jing Tan, Fang-Fang Wang, Ning-Ning Hou, Yu-Qian Xiang, Jun-Yu Zhang, Ye Liu, Fan Qu, Qing Meng, Jian Xu, Jian-Zhong Sheng and He-Feng Huang*. Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis. Clinical Epigenetics. 2018;10. PMID: 29344314.

  12. Kun Li#, Rui Li, Ya Ni, Peibei Sun, Ye Liu, Dan Zhang & Hefeng Huang*. Novel distance-progesterone-combined selection approach improves human sperm quality. Journal of Translational Medicine. 2018;16. PMID: 30029659.

  13. Cheng Li#, Hui-Yu Zhang#, Yan Liang, Wei Xia, Qian Zhu, Duo Zhang, Zhen Huang, Gui-Lin Liang, Rui-Hong Xue, Hang Qi, Xiao-Qing He, Jiang-Jing Yuan, Ya-Jing Tan, He-Feng Huang* and Jian Zhang*. Effects of Levonorgestrel and progesterone on Oviductal physiology in mammals. Reproductive Biology and Endocrinology. 2018;16:1-8.PMID: 29925391.

  14. Li Jin#, Qian Yang#, Chengliang Zhou, Lanxin Liu, Huihui Wang, Min Hou, Yimei Wu, Fengtao Shi, Jianzhong Sheng, Hefeng Huang*. Profiles for long non-coding RNAs in ovarian granulosa cells from women with PCOS with or without hyperandrogenism. Reproductive Biomedicine Online. 2018;37(5):613-23. PMID: 30224242.

  15. Hong-Tao Hu#, Jing-Jing Xu#, Jing Lin, Cheng Li, Yan-Ting Wu, Jian-Zhong Sheng, Xin-Mei Liu* and He-Feng Huang*. Association between first caesarean delivery and adverse outcomes in subsequent pregnancy: a retrospective cohort study. Bmc Pregnancy and Childbirth. 2018,18(1):273. PMID:?29954355.

  16. Lihua Hong#Tiantian YuHaiyan XuNingning HouQi ChengLihua LaiQingqing Wang, Jianzhong Sheng 5Hefeng Huang*. Down-regulation of miR-378a-3p induces decidual cell apoptosis: a possible mechanism for early pregnancy loss. Human Reproduction. 2018;33(1):11-22.PMID: 29165645.

  17. Lingjuan He#, Yan Li, Xiuzhen Huang, Yi Li, Wenjuan Pu, Xueying Tian, Dongqing Cai, Hefeng Huang, Kathy O Lui, Bin Zhou*. Genetic lineage tracing of resident stem cells by DeaLT. Nature Protocols. 2018;13(10):2217-46. PMID: 30250288.

  18. Rong Ding#Fei GuoYong ZhangXi-Mei LiuYu-Qian XiangChen ZhangZhi-Wei LiuJian-Zhong ShengHe-Feng HuangJun-Yu Zhang*Jian-Xia Fan*. Integrated Transcriptome Sequencing Analysis Reveals Role of miR-138-5p/ TBL1X in Placenta from Gestational Diabetes Mellitus. Cellular Physiology and Biochemistry. 2018;51(2):630-46. PMID: 30463081.

  19. Xi-Jing Chen#, Feng Chen#, Ping-Ping Lv, Dan Zhang, Guo-Lian Ding, Xiao-Ling Hu, Chun Feng, Jian-Zhong Sheng, He-Feng Huang*. Maternal high estradiol exposure alters CDKN1C and IGF2 expression in human placenta. Placenta. 2018;61:72-9.PMID: 29277274.

  20. Songchang Chen#, Shuyuan Li#, Junyu Zhang, Lanlan Zhang, Yiyao Chen, Li Wang, Li Jin, Yuting Hu, Xiaoping Qi* , Hefeng Huang*, Chenming Xu*. Preimplantation Genetic Diagnosis of Multiple Endocrine Neoplasia Type 2A Using Informative Markers Identified by Targeted Sequencing. Thyroid. 2018;28(3):281-7.PMID: 29378479.


  1. Ying Zhang#, Yong Zhang#, Chunbo Zhao, Tiantian Yu, Ye Liu, Weihui Shi, Fengtao Shi, Xinmei Liu, Jianzhong Sheng, Hefeng Huang* and Hong Xu*. Reduced alternative splicing of estrogen receptor alpha in the endometrium of women with endometriosis. Oncotarget. 2017;8(66):110176-86.PMID: 29299139.

  2. Yong Zhang#, Ying Zhang#, Guo-Lian Ding, Xin-Mei Liu, Jianping Ye, JianZhong Sheng, Jianxia Fan*, He-Feng Huang*. Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia. Oncotarget. 2017;8(9):15205-12. PMID: 28148899.

  3. Yong Zhang#, Xiaobei Dai#, Shuai Yang, Chen Zhang, Mi Han, He-Feng Huang*, Jianxia Fan*. Maternal low thyroxin levels are associated with adverse pregnancy outcomes in a Chinese population. Plos One. 2017;12(5). PMID: 28542464.

  4. Jun-Yu Zhang#, Song-Chang Chen#, Yi-Yao Chen, Shu-Yuan Li, Lan-Lan Zhang, Ying-Hua Shen, Chun-Xin Chang, Yu-Qian Xiang, He-Feng Huang, Chen-Ming Xu*. Targeted sequencing identifies a novel SH2D1A pathogenic variant in a Chinese family: Carrier screening and prenatal genetic testing. Plos One. 2017;12(2).PMID: 28231257.

  5. Huijuan Zhang#, Guishuan Wang, Lin Liu, Xiaolin Liang, Yu Lin, Yi-Yu Lin, Chu-Fang Chou, Mo-Fang Liu, Hefeng Huang* and Fei Sun*. KH-type splicing regulatory protein is a new component of chromatoid body. Reproduction. 2017;154(6):723-33. PMID: 28871057.

  6. Gu-Feng Xu#, Cheng-Liang Zhou#, Yi-Meng Xiong, Jing-Yi Li, Tian-Tian Yu, Shen Tian, Xian-Hua Lin, Yun Liao, Yuan Lv, Fang-Hong Zhang, Zhi-Wei Liu, Yin-Yin Shi, Yan Shen, Jin Sha, Dan Zhang, Yi-Min Zhu, Jian-Zhong Sheng, He-Feng Huang*. Reduced Intellectual Ability in Offspring of Ovarian Hyperstimulation Syndrome: A Cohort Study. Ebiomedicine. 2017;20:263-7. PMID: 28532740.

  7. Yan-Ting Wu#, Hsun-Ming Chang, He-Feng Huang, Jian-Zhong Sheng*, Peter C K Leung*. Bone morphogenetic protein 2 regulates cell-cell communication by down-regulating connexin43 expression in luteinized human granulosa cells. Molecular Human Reproduction. 2017;23(3):155-65. PMID: 27986931.

  8. Yu Wu#, Hong Pan#, Wei-Ming Wang, Ding Xu, Liang Zhang, Zheng-Qin Gu, Qiang Bai, Jun Qi, He-Feng Huang*. A possible relationship between serum sex hormones and benign prostatic hyperplasia/lower urinary tract symptoms in men who underwent transurethral prostate resection. Asian Journal of Andrology. 2017;19(2):230-3. PMID: 26763548.

  9. Kamran Ullah#, Tanzil Ur Rahman#, Dan-Dan Wu, Xian-Hua Lin, Ye Liu, Xiao-Yan Guo, Peter CK Leung, Run-Ju Zhang, He-Feng Huang, Jian-Zhong Sheng*. Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome. Clinica Chimica Acta. 2017;471:243-7. PMID: 28624500.

  10. Kamran Ullah#, Tanzil Ur Rahman#, Hai-Tao Pan, Meng-Xi Guo, Xin-Yan Dong, Juan Liu, Lu-Yang Jin, Yi Cheng, Zhang-Hong Ke, Jun Ren, Xian-Hua Lin, Xiao-Xiao Qiu, Ting-Ting Wang, He-Feng Huang*, Jian-Zhong Sheng*. Serum estradiol levels in controlled ovarian stimulation directly affect the endometrium. Journal of Molecular Endocrinology. 2017;59(2):105-19. PMID: 28539318.

  11. Shen Tian#Xian-Hua Lin#Yi-Meng Xiong#Miao-E LiuTian-Tian YuMin LvWei ZhaoGu-Feng XuGuo-Lian DingChen-Ming XuMin JinChun FengYan-Ting WuYa-Jing TanQian GaoJian ZhangCheng LiJun RenLu-Yang JinBin ChenHong ZhuXue-Ying ZhangSong-Chang ChenXin-Mei LiuYe LiuJun-Yu ZhangLi WangPing ZhangXiao-Jun ChenLi JinXi ChenYi-Cong MengDan-Dan WuHui LinQian YangCheng-Liang ZhouXin-Zhu LiYi-Yu WangYu-Qian XiangZhi-Wei LiuLing GaoLu-Ting ChenHong-Jie PanRong LiFang-Hong ZhangLan-Feng XingYi-Min ZhuChristian KlausenPeter CK LeungJu-Xue LiFei SunJian-Zhong Sheng , He-Feng Huang*. Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism. Ebiomedicine. 2017;16:275-83. PMID: 28111236.

  12. Yi-Xi Sun#, Yi-Xin Zhang#, Dan Zhang#, Chen-Ming Xu, Song-Chang Chen, Jun-Yu Zhang, Ye-Chun Ruan, Feng Chen, Run-Ju Zhang, Ye-Qing Qian, Yi-Feng Liu, Lu-Yang Jin, Tian-Tian Yu, Hai-Yan Xu, Yu-Qin Luo, Xin-Mei Liu, Fei Sun, Jian-Zhong Sheng, He-Feng Huang*. XCI-escaping gene KDM5C contributes to ovarian development via downregulating miR-320a. Human Genetics. 2017;136(2):227-39. PMID: 27896428.

  13. Feng Sun#Wei QianChen ZhangJian-Xia Fan*He-Feng Huang*. Correlation of Maternal Serum Homocysteine in the First Trimester with the Development of Gestational Hypertension and Preeclampsia. Medical Science Monitor. 2017;23:5396-401. PMID: 29129906.

  14. Tanzil Ur Rahman#, Kamran Ullah#, Zhang-Hong Ke, Meng-Xi Guo, Lu-Yang Jin, Jun Ren, Yu-Zhong Zhou, Yi Cheng, Xin-Yan Dong, Hai-Yan Pang, Ting-Ting Wang, Jian-Zhong Sheng* and He-Feng Huang*. Hypertriglyceridemia in female rats during pregnancy induces obesity in male offspring via altering hypothalamic leptin signaling. Oncotarget. 2017;8(32):53450-64.PMID: 28881823.

  15. Xian-hua Lin#, Hui Wang#, Dan-dan Wu#, Kamran Ullah, Tian-tian Yu, Tanzil Ur Rahman, He-feng Huang*. High Leptin Level Attenuates Embryo Development in Overweight/Obese Infertile Women by Inhibiting Proliferation and Promotes Apoptosis in Granule Cell. Hormone and Metabolic Research. 2017;49(7):534-41. PMID: 28561185.

  16. Ziru Jiang#, Yinyu Wang, Jing Lin, Jingjing Xu, Guolian Ding, Hefeng Huang*. Genetic and epigenetic risks of assisted reproduction. Best Practice & Research Clinical Obstetrics & Gynaecology. 2017;44:90-104. PMID: 28844405.

  17. Lingjuan He#Yan LiYi LiWenjuan PuXiuzhen HuangXueying TianYue WangHui ZhangQiaozhen LiuLibo ZhangHuan ZhaoJuan TangHongbin JiDongqing CaiZhibo HanZhongchao HanYu NieShengshou HuQing-Dong WangRuilin SunJian FeiFengchao WangTing ChenYan YanHefeng HuangWilliam T PuBin Zhou*. Enhancing the precision of genetic lineage tracing using dual recombinases. Nature Medicine.2017 Dec;23(12):1488-1498. PMID: 29131159.

  18. Xiao-Yan Guo#, Xin-Mei Liu, Li Jin, Ting-Ting Wang, Kamran Ullah, Jian-Zhong Sheng, He-Feng Huang*. Cardiovascular and metabolic profiles of offspring conceived by assisted reproductive technologies: a systematic review and meta-analysis. Fertility and Sterility. 2017;107(3):622-631. PMID: 28104241. IF=7.49

  19. Songchang Chen#, Deyuan Liu#, Junyu Zhang#, Shuyuan Li, Lanlan Zhang, Jianxia Fan, Yuqin Luo, Yeqing Qian, Hefeng Huang, Chao Liu, Huanhuan, Zhengwen Jiang* and Chenming Xu*. A copy number variation genotyping method for aneuploidy detection in spontaneous abortion specimens. Prenatal Diagnosis. 2017;37(2):176-83. PMID: 27977861.

  20. Lu-Ting Chen#, Fan Qu, Fang-Hong Zhang, Yan-Ting Wu, Lan-Feng Xing & HeFeng Huang*. Maternal anxiety associated with in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) outcomes and risk of difficult toddler temperament: A three-year case-control study. Journal of Obstetrics and Gynaecology. 2017;37(7):965-9. PMID: 28578600.


  1. Linling Zhu#Yu ZhangYifeng LiuRunjv ZhangYiqing WuYun HuangFeng LiuMeigen LiSaijun SunLanfeng XingYimin ZhuYiyi ChenLi XuLiangbi ZhouHefeng Huang*Dan Zhang*. Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study. Scientific Reports.2016;6:35141. PMID: 27762324.

  2. Meng-Dan Zhao#Jin-Lin ChengJing-Jing YanFeng-Ying ChenJian-Zhong ShengDong-Li SunJian ChenJing MiaoRun-Ju ZhangCai-Hong Zheng*He-Feng Huang*. Hyaluronic acid reagent functional chitosan-PEI conjugate with AQP2-siRNA suppressed endometriotic lesion formation. International Journal of Nanomedicine. 2016;11:1323-36.PMID: 27099493.

  3. Ping Zhang#Ningling Wang#Xianhua LinLi JinHong Xu*Rong LiHefeng Huang*. Expression and localization of heterogeneous nuclear ribonucleoprotein K in mouse ovaries and preimplantation embryos. Biochemical and Biophysical Research Communications. 2016;471(1):260-5.PMID: 26850853.

  4. Dan Zhang#, Gufeng Xu, Runju Zhang, Yimin Zhu, Huijuan Gao, Caiyun Zhou, Jianzhong Sheng, Hefeng Huang*. Decreased expression of aquaporin 2 is associated with impaired endometrial receptivity in controlled ovarian stimulation. Reproduction Fertility and Development. 2016;28(4):499-506. PMID: 25232826.

  5. Shuai Yang#, Feng-Tao Shi#, Peter C. K. Leung, He-Feng Huang*and Jianxia Fan*. Low Thyroid Hormone in Early Pregnancy Is Associated With an Increased Risk of Gestational Diabetes Mellitus. Journal of Clinical Endocrinology & Metabolism. 2016;101(11):4237-43. PMID: 27583471.

  6. Lu Wang#, Fei Xu, Guishuan Wang, Xiaorong Wang, Ajuan Liang, Hefeng Huang*& Fei Sun*. C30F12.4 influences oogenesis, fat metabolism, and lifespan in C-elegans. Protein & Cell. 2016;7(10):714-21.PMID: 27638466.

  7. Lu Wang#Yueshuai GuoWenjing LiuWeidong ZhaoGendi SongTao ZhouHefeng HuangXuejiang Guo*Fei Sun*. Proteomic Analysis of Pachytene Spermatocytes of Sterile Hybrid Male Mice. Biology of Reproduction. 2016;95(3). PMID: 27465139.

  8. Yang Song#, En-Sheng Wang, Li-Li Xing, Shuai Shi, Fan Qu, Dan Zhang, Jing-Yi Li, Jing Shu, Ye Meng, Jian-Zhong Sheng, Jian-Hong Zhou, and He-Feng Huang*. Follicle-Stimulating Hormone Induces Postmenopausal Dyslipidemia Through Inhibiting Hepatic Cholesterol Metabolism. Journal of Clinical Endocrinology & Metabolism. 2016;101(1):253-62. PMID: 26583582.

  9. Jing Shu#Li-Li XingGuo-Lian DingXin-Mei LiuQing-Feng YanHe-Feng Huang*. Effects of ovarian hyperstimulation on mitochondria in oocytes and early embryos. Reproduction Fertility and Development. 2016;28(8):1214-22. PMID: 25659297.

  10. H Pan#,P Zhang#,J-R Li,H Wang,M-F Jin,C Feng,H-F Huang*. c-Fos-Regulated Matrix Metalloproteinase-9 Expression is Involved in 17 beta-Estradiol-Promoted Invasion of Human Endometrial Stromal Cell. Current Molecular Medicine. 2016;16(3):266-75. PMID: 26917263.

  11. Ping-Ping Lv#, Shen Tian#, Chun Feng, Jing-Yi Li, Dan-Qin Yu, Li Jin, Yan Shen, Tian-Tian Yu, Ye Meng, Guo-Lian Ding, Min Jin, Xi-Jing Chen, Jian-Zhong Sheng, Dan Zhang*, He-Feng Huang*. Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring. Scientific Reports. 2016;6. PMID: 27827435.

  12. Yong Chao Lu#Jing Yang#Kin Lam FokYing Hui YeLiang JinZheng Yun ChenXin Mei ZhangHe Feng Huang*Hsiao Chang Chan*. Involvement of Cl-/HCO3- exchanger SLC26A3 and SLC26A6 in preimplantation embryo cleavage. Scientific Reports. 2016;6. PMID: 27346053.

  13. A-X Liu#, D Zhang, Y-M Zhu, H-J Gao, J-Y Jiang, X-L Hu, P-P Lv, P C K Leung, H-F Huang*. Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. Current Molecular Medicine. 2016;16(3):299-311. PMID: 26917260.

  14. Xian-Hua Lin#Dan-Dan Wu#Ling Gao#Jun-Yu ZhangHai-Tao PanHui WangCheng LiPing ZhangMeng-Xi GuoYan-Ting WuYa-Jing TanLi JinYu-Qian XiangJu-Xue LiJian-Zhong ShengHe-Feng Huang*. Altered DNA methylation in neonates born large-for-gestational-age is associated with cardiometabolic risk in children. Oncotarget. 2016;7(52):86511-21.PMID: 27888796.

  15. Zhang-Hong Ke#Jie-Xue Pan#Lu-Yang JinHai-Yan XuTian-Tian YuKamran UllahTanzil Ur RahmanJun RenYi ChengXin-Yan DongJian-Zhong ShengHe-Feng Huang*. Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism. Scientific Reports. 2016;6. PMID: 27502578.

  16. Min Jin#, Ping-Ping Lv, Tian-Tian Yu, Jin-Ming Shen, Chun Feng, He-Feng Huang. IGFBP1 Involved in the Decreased Birth Weight Due to Fetal High Estrogen Exposure in Mice. Biology of Reproduction. 2016;95(5). PMID: 27628217.

  17. Ningning Hou#, Songchang Chen, Feng Chen, Minmin Jiang, Junyu Zhang, Yanmei Yang, Bo Zhu, Xiaoxia Bai, Yuting Hu, Hefeng Huang*, Chenming Xu*. Association between premature ovarian failure, polymorphisms in MTHFR and MTRR genes and serum homocysteine concentration. Reproductive Biomedicine Online. 2016;32(4):407-13. PMID: 26874989.

  18. Ling Gao#, Yi-Chao Zhao, Yan Liang, Xian-Hua Lin, Ya-Jing Tan, Dan-Dan Wu, Xin-Zhu Li, Bo-Zhi Ye, Fan-Qi Kong, Jian-Zhong Sheng, He-Feng Huang*. The impaired myocardial ischemic tolerance in adult offspring of diabetic pregnancy is restored by maternal melatonin treatment. Journal of Pineal Research. 2016;61(3):340-52. PMID: 27299979.

  19. Ling Gao#, Jia-Tian Cao, Yan Liang, Yi-Chao Zhao, Xian-Hua Lin, Xiao-Cui Li, Ya-Jing Tan, Jing-Yi Li, Cheng-Liang Zhou, Hai-Yan Xu, Jian-Zhong Sheng, He-Feng Huang*. Calcitriol attenuates cardiac remodeling and dysfunction in a murine model of polycystic ovary syndrome. Endocrine. 2016;52(2):363-73. PMID: 26578366.

  20. Jian-Xia Fan#, Shuai Yang, Wei Qian, Feng-Tao Shi, He-Feng Huang*. Comparison of the Reference Intervals Used for the Evaluation of Maternal Thyroid Function During Pregnancy Using Sequential and Nonsequential Methods. Chinese Medical Journal. 2016;129(7):785-91. PMID: 26996472.

  21. Song-Chang Chen#Xiao-Li Xu#Jun-Yu ZhangGuo-Lian DingLi JinBei LiuDong-Mei SunChang-Lin MeiXiao-Nan YangHe-Feng HuangChen-Ming Xu*. Identification of PKD2 mutations in human preimplantation embryos in vitro using a combination of targeted next-generation sequencing and targeted haplotyping. Scientific Reports. 2016;6:25488. PMID: 27150309.


  1. Jian Zhang#, Cheng Li#, Wei-Hong Zhao, Xiaowei Xi, Shu-Jun Cao, Hua Ping, Guo-Juan Qin, Linan Cheng & He-Feng Huang*. Association between levonorgestrel emergency contraception and the risk of ectopic pregnancy: a multicenter case-control study. Scientific Reports. 2015,5:8487. PMID: 25674909.

  2. Dan Zhang#Jingyi LiGufeng XuRunjv ZhangChengliang ZhouYeqing QianYifeng LiuLuting ChenBo ZhuXiaoqun YeFan QuXinmei LiuShuai ShiWeijun YangJianzhong ShengHefeng Huang*. Follicle-stimulating hormone promotes age-related endometrial atrophy through cross-talk with transforming growth factor beta signal transduction pathway. Aging Cell. 2015;14(2):284-7. PMID: 25393561.

  3. Jing Yang#, Dan Zhang#, Ying Yu, Run-Ju Zhang, Xiao-Ling Hu, He-Feng Huang, Yong-Chao Lu*. Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway. Cell Cycle. 2015;14(20):3318-30. PMID: 26378412.

  4. Yan-Ting Wu#, Yan Wu, Jun-Yu Zhang, Ning-Ning Hou, Ai-Xia Liu, Jie-Xue Pan, Jie-Yang Lu, Jian-Zhong Sheng, He-Feng Huang*. Preliminary proteomic analysis on the alterations in follicular fluid proteins from women undergoing natural cycles or controlled ovarian hyperstimulation. Journal of Assisted Reproduction and Genetics. 2015;32(3):417-27. PMID: 25595538.

  5. Yong Wang#, Wenjing Liu#, Juan Du, Yang Yu, Ning Liang, Meng Liang, Guidong Yao, Sheng Cui, Hefeng Huang*, Fei Sun. NGF promotes mouse granulosa cell proliferation by inhibiting ESR2 mediated down-regulation of CDKN1A. Molecular and Cellular Endocrinology. 2015;406(C):68-77. PMID: 25737208.

  6. Li-Ya Wang#, Ning Wang, Fang Le, Lei Li, Hang-Ying Lou, Xiao-Zhen Liu, Ying-Ming Zheng, Ye-Qing Qian, Yun-Long Chen, Xin-Hang Jiang, He-Feng Huang, Fan Jin*. Superovulation Induced Changes of Lipid Metabolism in Ovaries and Embryos and Its Probable Mechanism. Plos One. 2015,10(7):e0132638. PMID: 26167919.

  7. Guishuan Wang#, Huijuan Zhang, Lu Wang, Yuan Wang, Hefeng Huang*, Fei Sun*. Ca2+/Calmodulin-Dependent Protein Kinase IV Promotes Interplay of Proteins in Chromatoid Body of Male Germ Cells. Scientific Reports. 2015, 5:12126. PMID: 26179157.

  8. Fangfang Wang#, Jiexue Pan#, Ye Liu, Qing Meng, Pingping Lv, Fan Qu, Guo-Lian Ding, Christian Klausen, Peter CK Leung, Hsiao Chang Chan, Weimiao Yao, Cai-Yun Zhou, Biwei Shi, Junyu Zhang, Jianzhong Sheng , Hefeng Huang*. Alternative splicing of the androgen receptor in polycystic ovary syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(15):4743-8. PMID: 25825716.

  9. Changxing Wang#, Yue Huang#, Jianzhong Sheng, Hefeng Huang, Jun Zhou*. Estrogen receptor alpha inhibits RLR-mediated immune response via ubiquitinating TRAF3. Cellular Signalling. 2015;27(10):1977-83. PMID: 26186972.

  10. Ya-Jing Tan#, Xue-Ying Zhang, Guo-Lian Ding, Rong Li, Li Wang, Li Jin, Xian-Hua Lin, Ling Gao, Jian-Zhong Sheng, He-Feng Huang*. Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation. Scientific Reports. 2015,5:17741. PMID: 26634435.

  11. Jie-Xue Pan#, Ye Liu, Zhang-Hong Ke, Cheng-Liang Zhou, Qing Meng, Guo-Lian Ding, Gu-Feng Xu, Jian-Zhong Sheng*, He-Feng Huang*. Successive and cyclic oral contraceptive pill pretreatment improves IVF/ICSI outcomes of PCOS patients and ameliorates hyperandrogenism and antral follicle excess. Gynecological Endocrinology. 2015;31(4):332-6.PMID: 25558892.

  12. Hai-Tao Pan#, Meng-Xi Guo#, Yi-Meng Xiong, Jun Ren, Jun-Yu Zhang, Qian Gao, Zhang-Hong Ke, Gu-Feng Xu, Ya-Jing Tan, Jian-Zhong Sheng*, He-Feng Huang*. Differential proteomic analysis of umbilical artery tissue from preeclampsia patients, using iTRAQ isobaric tags and 2D nano LC-MS/MS. Journal of Proteomics. 2015;112:262-73. PMID: 25234496.

  13. Ye Meng#, Ping-Ping Lv#, Guo-Lian Ding, Tian-Tian Yu, Ye Liu, Yan Shen, Xiao-Ling Hu, Xian-Hua Lin, Shen Tian, Min Lv, Yang Song, Meng-Xi Guo, Zhang-Hong Ke, Hong Xu, Jian-Zhong Sheng, Feng-Tao Shi*, He-Feng Huang*. High Maternal Serum Estradiol Levels Induce Dyslipidemia in Human Newborns via a Hepatic HMGCR Estrogen Response Element. Scientific Reports. 2015,5:10086. PMID: 25961186.

  14. Xin-Mei Liu#, Hsiao Chang Chan#, Guo-Lian Ding, Jie Cai, Yang Song, Ting-Ting Wang, Dan Zhang, Hui Chen, Mei Kuen Yu, Yan-Ting Wu, Fan Qu, Ye Liu, Yong-Chao Lu, Eli Y Adashi, Jian-Zhong Sheng*, He-Feng Huang*. FSH regulates fat accumulation and redistribution in aging through the Gai/Ca2+/CREB pathway. Aging Cell. 2015;14(3):409-20.PMID: 25754247.

  15. Bei Liu#, Song-Chang Chen#, Yan-Mei Yang, Kai Yan, Ye-Qing Qian, Jun-Yu Zhang, Yu-Ting Hu, Min-Yue Dong, Fan Jin, He-Feng Huang, Chen-Ming Xu*. Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease. Scientific Reports. 2015;5:17468. PMID: 26632257.

  16. Xian-Hua Lin#, Miao-E Liu, Hai-Yan Xu, Xue-Jun Chen, Hui Wang, Shen Tian, Jian-Zhong Sheng, He-Feng Huang*. Leptin down-regulates gamma-ENaC expression: a novel mechanism involved in low endometrial receptivity. Fertility and Sterility. 2015;103(1):228-35.PMID: 25450293.

  17. Yi-Ting Huang#, Jun Zhou, Shuai Shi, Hai-Yan Xu, Fan Qu, Dan Zhang, Yi-Ding Chen, Jing Yang, He-Feng Huang*, Jian-Zhong Sheng*. Identification of Estrogen Response Element in Aquaporin-3 Gene that Mediates Estrogen-induced Cell Migration and Invasion in Estrogen Receptor-positive Breast Cancer. Scientific Reports. 2015;5:12484. PMID: 26219409.

  18. Wensheng Hu#, Hanzhi Wang and Hefeng Huang*. Analysis of gene expression and preliminary study of methylation about 11 beta-HSD2 gene in placentas of Chinese pre-eclampsia patients of Han ethnicity. Journal of Obstetrics and Gynaecology Research. 2015;41(3):343-9. PMID: 25331012.

  19. Guo-Lian Ding#Ye Liu#Miao-E LiuJie-Xue PanMeng-Xi GuoJian-Zhong ShengHe-Feng Huang*. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Asian Journal of Andrology. 2015;17(6):948-53. PMID: 25814158.

  20. Hsun-Ming Chang#, Jung-Chien Cheng, He-Feng Huang, Feng-Tao Shi*, Peter CK Leung*. Activin A, B and AB decrease progesterone production by down-regulating StAR in human granulosa cells. Molecular and Cellular Endocrinology. 2015;412(C):290-301.PMID: 26001835.

  21. Wang B#, Fang Y, Wu Y, Koga K, Osuga Y, Lv S, Chen D, Zhu Y, Wang J, Huang H*. Viperin is induced following toll-like receptor 3 (TLR3) ligation and has a virus-responsive function in human trophoblast cells. Placenta. 2015 Jun;36(6):667-73. PMID: 25814471.


  1. Qiyin Zhou#, Ling Pan#, Songchang Chen, Fang Chen, Rosa Hwang, Xiaonan Yang, Wei Wang, Jingyi Jiang, Jian Xu, Hefeng Huang, Chenming Xu*. Clinical application of noninvasive prenatal testing for the detection of trisomies 21, 18, and 13: a hospital experience. Prenatal Diagnosis. 2014,34(11):1061-5. PMID: 24899146.

  2. Ying Yu#, Hai-Yan Shi & He-Feng Huang*. Uterine perivascular epithelioid cell tumour. Journal of Obstetrics and Gynaecology. 2014,34(6):519-22. PMID: 24833025.

Xiang-Rong Xu#, Rong-Guo Fu#, Li-Ya Wang#, Ning Wang, Fan Zhang, Fang Le, Lei Li, Le-Jun Li, Xiao-Zhen Liu, Ying-Ming Zheng, Hang-Ying Lou, Shi-Wen Jiang, Xiao-Ming Zhu, Yi-Min Zhu, He-Feng Huang, Fan Jin*. Epigenetic Inheritance of Paternally Expressed Imprinted Genes in the Testes of ICSI Mice. Current Pharmaceutical Design. 2014;20(11):1764-71. PMID: 23909805.

  1. Jian Xu#Junyi Ye#Yanting WuHong ZhangQiong LuoCong HanXiaoqun YeHanzhi WangJing HeHefeng HuangYun Liu*Minyue Dong*. Reduced Fetal Telomere Length in Gestational Diabetes. Plos One. 2014,9(1):e86161. PMID: 24465936.

  2. Gu-Feng Xu#, Jun-Yu Zhang#, Hai-Tao Pan, Shen Tian, Miao-E Liu, Tian-Tian Yu, Jing-Yi Li, Wei-Wen Ying, Wei-Miao Yao, Xian-Hua Lin, Yuan Lv, Wen-Wen Su, Xiao-Qun Ye, Fang-Hong Zhang, Jie-Xue Pan, Ye Liu, Cheng-Liang Zhou, Dan Zhang, Xin-Mei Liu, Yi-Min Zhu, Jian-Zhong Sheng, He-Feng Huang*. Cardiovascular dysfunction in offspring of ovarian-hyperstimulated women and effects of estradiol and progesterone: a retrospective cohort study and proteomics analysis. The Journal of clinical endocrinology and metabolism. 2014 Dec;99(12):E2494-503. PMID: 25268391.

  3. Wang Liquan#, Huang Hefeng*, Jin Fan, Zhou Caiyun, Qian Yuli and Chen Jianhua. High expression of follicle stimulating hormone receptor in testicular tissue of idiopathic azoospermic patients with severe spermatogenic defects. Chinese Medical Journal. 2014;127(3):488-93. PMID: 24451955

  4. Fan Qu#, Dan Zhang#, Lu-Ting Chen, Fang-Fang Wang, Jie-Xue Pan, Yi-Min Zhu, Chun-Mei Ma, Yi-Ting Huang, Xiao-Qun Ye, Sai-Jun Sun, Wen-Jun Zheng, Run-Ju Zhang, Jian Xu, Lan-Feng Xing*, He-Feng Huang*. Auricular Acupressure Reduces Anxiety Levels and Improves Outcomes of in Vitro Fertilization: A Prospective, Randomized and Controlled Study. Scientific Reports. 2014, 4:5028.PMID: 24848522.

  5. Ping-Ping Lv#, Ye Meng#, Min Lv, Chun Feng, Ye Liu, Jing-Yi Li, Dan-Qin Yu, Yan Shen, Xiao-Lin Hu, Qian Gao, Shan Dong, Xian-Hua Lin, Gu-Feng Xu, Shen Tian, Dan Zhang, Fang-Hong Zhang, Jie-Xue Pan, Xiao-Qun Ye, Miao-E Liu, Xin-Mei Liu, Jian-Zhong Sheng, Guo-Lian Ding*, He-Feng Huang*. Altered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of pregnancy: a cross-sectional study. Bmc Medicine. 2014,12.PMID: 25511686.

  6. Yong-Chao Lu#Jing Yang#Guo-Lian DingShuai ShiDan ZhangLi JinJie-Xue PanXian-Hua LinYi-Min ZhuJian-Zhong Sheng*He-Feng Huang*. Small-Conductance, Calcium-Activated Potassium Channel 3 (SK3) Is a Modulator of Endometrial Remodeling During Endometrial Growth. Journal of Clinical Endocrinology & Metabolism. 2014;99(10):3800-10.PMID: 24978672.

  7. Hangying Lou#, Fang Le, Yingming Zheng, Lejun Li, Liya Wang, Ning Wang, Yimin Zhu, Hefeng Huang, Fan Jin*. Assisted reproductive technologies impair the expression and methylation of insulin-induced gene 1 and sterol regulatory element-binding factor 1 in the fetus and placenta. Fertility and Sterility. 2014,101(4):974-980. PMID: 24484994.

  8. Xiaozhen Liu#Dongmei Zhao#Yingming ZhengLiya WangYuli QianChenming XuHefeng HuangYi Lisa HwaFan Jin*. Expression of Histone Acetyltransferase GCN5 and Histone Deacetylase 1 in the Cultured Mouse Preimplantation Embryos. Current Pharmaceutical Design. 2014;20(11):1772-7. PMID: 23888963.

  9. Xin-Mei Liu#, Dan Zhang, Ting-Ting Wang, Jian-Zhong Sheng, He-Feng Huang*. Ion/Water Channels for Embryo Implantation Barrier. Physiology. 2014;29(3):186-95. PMID: 24789983.

  10. Ai-Xia Liu#Hai-Yan Shi#Zhe-Jun CaiAiping LiuDan ZhangHe-Feng Huang*Hang-Mei Jin*. Increased risk of gonadal malignancy and prophylactic gonadectomy: a study of 102 phenotypic female patients with Y chromosome or Y-derived sequences. Human Reproduction. 2014;29(7):1413-9.PMID: 24826988.

  11. Meng Liang#, Wenqing Li#, Hui Tian, Tao Hu, Lu Wang, Yu Lin, Yulei Li, Hefeng Huang, Fei Sun*. Sequential expression of long noncoding RNA as mRNA gene expression in specific stages of mouse spermatogenesis. Scientific Reports. 2014;4. PMID: 25097017.

  12. Le-Jun Li#, Feng-Bin Zhang, Shu-Yuan Liu, Yong-Hong Tian, Fang Le, Li-Ya Wang, Hang-Ying Lou, Xiang-Rong Xu, He-Feng Huang, Fan Jin*. Human Sperm Devoid of Germinal Angiotensin-Converting Enzyme Is Responsible for Total Fertilization Failure and Lower Fertilization Rates by Conventional In Vitro Fertilization. Biology of Reproduction. 2014;90(6). PMID: 24790158.

  13. Le-Jun Li#, Feng-Bin Zhang, Shu-Yuan Liu, Yong-Hong Tian, Fang Le, Hang-Ying Lou, He-Feng Huang, Fan Jin*. Decreased expression of SAM68 in human testes with spermatogenic defects. Fertility and Sterility. 2014,102(1):61-67. PMID: 24794312.

  14. Jie Li#, Qiuyuan Zhu, Hanzhi Wang, Cong Han, Qunyan Zhou, Hefeng Huang, Minyue Dong*. Decreased fetal pre-adipocyte factor-1 in pregnancies complicated by gestational diabetes mellitus. Clinica Chimica Acta. 2014;431:93-5. PMID: 24518358.

  15. Yan-Jun Hu#*, Yue-Zhou Chen, Yi-Min Zhu, He-Feng Huang*. Letrozole stimulation in endometrial preparation for cryopreserved-thawed embryo transfer in women with polycystic ovarian syndrome: A pilot study. Clinical Endocrinology. 2014;80(2):283-9. PMID: 23808904.

  16. Xiao-Ling Hu#, Chun Feng#, Xian-Hua Lin, Zi-Xing Zhong, Yi-Min Zhu, Ping-Ping Lv, Min Lv, Ye Meng, Dan Zhang, Xiu-E Lu, Fan Jin, Jian-Zhong Sheng, Jian Xu, He-Feng Huang*. High Maternal Serum Estradiol Environment in the First Trimester Is Associated With the Increased Risk of Small-for-Gestational-Age Birth. Journal of Clinical Endocrinology & Metabolism. 2014;99(6):2217-24. PMID: 24606075.

  17. Wensheng Hu#, Xiaoling Weng#, Minyue Dong, Yun Liu, Wenjuan Li, Hefeng Huang*. Alteration in methylation level at 11 beta-hydroxysteroid dehydrogenase type 2 gene promoter in infants born to preeclamptic women. Bmc Genetics. 2014,15:96. PMID: 25200528.

  18. Qian Gao#, Hai-Tao Pan, Xian-Hua Lin, Jun-Yu Zhang, Ying Jiang, Shen Tian, Lu-Ting Chen, Miao-E Liu, Yi-Meng Xiong, He-Feng Huang*, Jian-Zhong Sheng*. Altered Protein Expression Profiles in Umbilical Veins: Insights into Vascular Dysfunctions of the Children Born after In Vitro Fertilization. Biology of Reproduction. 2014;91(3). PMID: 25100710.

  19. Guo-Lian Ding#He-Feng Huang*. Role for Tet in Hyperglycemia-Induced Demethylation: A Novel Mechanism of Diabetic Metabolic Memory. Diabetes. 2014;63(9):2906-8. PMID: 25146472.

  20. Danqing Chen#, Aiping Zhang#, Min Fang, Rong Fang, Jiamei Ge, Yuan Jiang, Hong Zhang, Cong Han, Xiaoqun Ye, Hefeng Huang, Yun Liu* and Minyue Dong*. Increased methylation at differentially methylated region of GNAS in infants born to gestational diabetes. Bmc Medical Genetics. 2014,15.PMID: 25269528.

  21. Lei Bao#, HaiDe Chen#, UiMyong Jong#, CholHo Rim#, WenLing Li, XiJuan Lin, Dan Zhang, Qiong Luo, Chun Cui, HeFeng Huang, Yan Zhang, Lei Xiao, ZhiXin Fu*. Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer. Science China-Life Sciences. 2014;57(2):263-8. PMID: 24430555.


  1. Li-Bo Zou#, Shuai Shi#, Run-Ju Zhang, Ting-Ting Wang, Ya-Jing Tan, Dan Zhang, Xiao-Yang Fei, Guo-Lian Ding, Qian Gao, Cheng Chen, Xiao-Ling Hu, He-Feng Huang*, Jian-Zhong Sheng*. Aquaporin-1 plays a crucial role in estrogen-induced tubulogenesis of vascular endothelial cells.The Journal of clinical endocrinology and metabolism. 2013,98(4):E672-82. PMID: 23450058.

  2. Qunyan Zhou#, Jie Li, Hanzhi Wang, Cong Han, Ting Tian, Qiuyuan Zhu, Hefeng Huang, Minyue Dong*. Serum preadipocyte factor-1 is increased in fetuses of pregnancy complicated with severe preeclampsia. Clinica Chimica Acta. 2013,424:212-5. PMID: 23810563.

  3. Ying-Ming Zheng#, Li Li#, Li-Ming Zhou, Fang Le, Li-Yi Cai, Ping Yu, Yu-Rong Zhu, Xiao-Zhen Liu, Li-Ya Wang, Le-Jun Li, Yi-Yun Lou, Xiang-Rong Xu, Hang-Ying Lou, Xiao-Ming Zhu, Jian-Zhong Sheng, He-Feng Huang, Fan Jin*. Alterations in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology. Human Reproduction. 2013;28(9):2570-80. PMID: 23861482.

  4. Jing Zheng#, Chenming Xu#, Jing Guo#, Yuan Wei#, Huijuan Ge, Xuchao Li, Chunlei Zhang, Haojun Jiang, Ling Pan, Weiping Tang, Weiwei Xie, Hongyun Zhang, Yangyu Zhao, Fuman Jiang, Shengpei Chen, Wei Wang, Xun Xu, Fang Chen*, Hefeng Huang*, Hui Jiang*. Effective Noninvasive Zygosity Determination by Maternal Plasma Target Region Sequencing. Plos One. 2013;8(6). PMID: 23762285.

  5. Yu Zhang#, Jung-Chien Cheng, He-Feng Huang*, Peter CK Leung*. Homeobox A7 stimulates breast cancer cell proliferation by up-regulating estrogen receptor-alpha. Biochemical and Biophysical Research Communications. 2013,440(4):652-7. PMID: 24099775.

  6. Yingfen Ying#, Lin Wang, Yaxia Chen, Jingyi Jiang, Yinluan Ouyang, Hefeng Huang, Jian Xu*. FTY720 and cyclosporin protect ovarian tissue grafted into rabbits. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2013,171(1):88-95. PMID: 24035595.

  7. Jing Xu#, Dong-Ping Chen, Zhi-Guo Mao, He-Feng Huang, Chen-Ming Xu, Cong-Rong Wang, Wei-Ping Jia, Chang-Lin Mei*. Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic dysplastic kidney. Bmc Nephrology. 2013;14. PMID: 23413949.  

  8. Yun Xiong#, Ya-Jing Tan, Yi-Meng Xiong, Yi-Ting Huang, Xiao-Ling Hu, Yong-Chao Lu, Ying-Hui Ye, Ting-Ting Wang, Dan Zhang, Fan Jin, He-Feng Huang*, Jian-Zhong Sheng*. Expression of Aquaporins in Human Embryos and Potential Role of AQP3 and AQP7 in Preimplantation Mouse Embryo Development. Cellular Physiology and Biochemistry. 2013;31(4-5):649-58. PMID: 23652731.

  9. Ting-Ting Wang#, Zhang-Hong Ke#, Yang Song, Lu-Ting Chen, Xi-Jing Chen, Chun Feng, Dan Zhang, Run-Ju Zhang, Yan-Ting Wu, Yu Zhang, Jian-Zhong Sheng, He-Feng Huang*. Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women. Human Reproduction. 2013;28(9):2473-81. PMID: 23851219.

  10. Li-ya Wang#, Ning Wang#, Fang Le, Lei Li, Le-jun Li, Xiao-zhen Liu, Ying-ming Zheng, Hang-ying Lou, Xiang-rong Xu, Xiao-ming Zhu, Yi-min Zhu, He-feng Huang, Fan Jin*. Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice. Journal of Zhejiang University-Science B. 2013,14(5):372-81. PMID: 23645174.

  11. Li-Ya Wang#, Fang Le, Ning Wang, Lei Li, Xiao-Zhen Liu, Ying-Ming Zheng, Hang-Ying Lou, Xiang-Rong Xu, Yun-Long Chen, Xiao-Ming Zhu, He-Feng Huang, Fan Jin*. Alteration of fatty acid metabolism in the liver, adipose tissue, and testis of male mice conceived through assisted reproductive technologies: fatty acid metabolism in ART mice. Lipids in Health and Disease. 2013,12:5. PMID: 23343123.

  12. Ya-Jing Tan#, Yun Xiong, Guo-Lian Ding, Dan Zhang, Ye Meng, He-Feng Huang*, Jian-Zhong Sheng*. Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation. Fertility and Sterility. 2013;99(5):1428-35. PMID: 23290745.

  13. Jing Shu#, Lili Xing, Guolian Ding, Qiong Luo, Xinmei Liu, Qingfeng Yan, Jianzhong Sheng, Hefeng Huang*. The Effect of Peritoneal Fluid from Patients with Endometriosis on Mitochondrial Function and Development of Early Mouse Embryos. Plos One. 2013,8(12). PMID: 24386092.

  14. Chol Ho Rim#, Zhixin Fu#, Lei Bao, Haide Chen, Dan Zhang, Qiong Luo, Hak Chol Ri, Hefeng Huang, Zhidong Luan, Yan Zhang, Chun Cui, Lei Xiao, Ui Myong Jong*. The effect of the number of transferred embryos, the interval between nuclear transfer and embryo transfer, and the transfer pattern on pig cloning efficiency. Animal Reproduction Science. 2013;143(1-4):91-6. PMID: 24238725.

  15. Qiong Luo#, Ying Jiang, Min Jin, Jian Xu, He-Feng Huang*. Proteomic Analysis on the Alteration of Protein Expression in the Early-Stage Placental Villous Tissue of Electromagnetic Fields Associated With Cell Phone Exposure. Reproductive Sciences. 2013;20(9):1055-61. PMID: 23420827.

  16. Fang Le#, Li Ya Wang, Ning Wang, Lei Li, Le Jun Li, Ying Ming Zheng, Hang Ying Lou, Xiao Zhen Liu, Xiang Rong Xu, Jian Zhong Sheng, He Feng Huang, Fan Jin*. In Vitro Fertilization Alters Growth and Expression of Igf2/H19 and Their Epigenetic Mechanisms in the Liver and Skeletal Muscle of Newborn and Elder Mice. Biology of Reproduction. 2013;88(3). PMID: 23390160.

  17. Jing He#, Aiping Zhang#, Min Fang, Rong Fang, Jiamei Ge, Yuan Jiang, Hong Zhang, Cong Han, Xiaoqun Ye, Danqing Yu, Hefeng Huang, Yun Liu*, Minyue Dong*. Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies. Bmc Genomics. 2013;14. PMID: 23844573.

  18. Guo-Lian Ding#, He-Feng Huang*. Paternal transgenerational glucose intolerance with epigenetic alterations in second generation offspring of GDM. Asian Journal of Andrology. 2013;15(4):451-2. PMID: 23749000.

  19. Shengpei Chen#, Tze Kin Lau#, Chunlei Zhang#, Chenming Xu, Zhengfeng Xu, Ping Hu, Jian Xu, Hefeng Huang, Ling Pan, Fuman Jiang, Fang Chen, Xiaoyu Pan, Weiwei Xie, Ping Liu, Xuchao Li, Lei Zhang, Songgang Li, Yingrui Li, Xun Xu, Wei Wang, Jun Wang, Hui Jiang*, Xiuqing Zhang*. A method for noninvasive detection of fetal large deletions/duplications by low coverage massively parallel sequencing. Prenatal Diagnosis. 2013,33(6):584-90. PMID: 23592436.


  1. Run-Ju Zhang#, Li-Bo Zou#, Dan Zhang, Ya-Jing Tan, Ting-Ting Wang, Ai-Xia Liu, Fan Qu, Ye Meng, Guo-Lian Ding, Yong-Chao Lu, Ping-Ping Lv, Jian-Zhong Sheng*, He-Feng Huang*. Functional Expression of Large-Conductance Calcium-Activated Potassium Channels in Human Endometrium: A Novel Mechanism Involved in Endometrial Receptivity and Embryo Implantation. Journal of Clinical Endocrinology & Metabolism. 2012;97(2):543-53.PMID: 22170720.

  2. Dan Zhang#, Ya-Jing Tan, Fan Qu, Jian-Zhong Sheng, He-Feng Huang*. Functions of water channels in male and female reproductive systems. Molecular Aspects of Medicine. 2012;33(5-6):676-90. PMID: 22343019.

  3. Dan Zhang#,Pingping Lv#,Runju Zhang,Qiong Luo,Guolian Ding,Lijun Yin,Jingyi Li,Gufeng Xu,Fan Qu,Jianzhong Sheng,Hefeng Huang*. A new model for embryo implantation: coculture of blastocysts and Ishikawa cells. Gynecological Endocrinology. 2012;28(4):288-92. PMID: 22106944.

  4. Li-Jun Yin#, Yu Zhang#, Ping-Ping Lv, Wei-Hua He, Yan-Ting Wu, Ai-Xia Liu, Guo-Lian Ding, Min-Yue Dong, Fan Qu, Chen-Ming Xu, Xiao-Ming Zhu, He-Feng Huang*. Insufficient maintenance DNA methylation is associated with abnormal embryonic development. Bmc Medicine. 2012;10. PMID: 22413869.

  5. Yan-Ting Wu#, Ting-Ting Wang#, Xi-Jing Chen, Xiao-Ming Zhu, Min-Yue Dong, Jian-Zhong Sheng, Chen-Ming Xu, He-Feng Huang*. Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders. Reproductive Biology and Endocrinology. 2012;10.PMID: 23268941.

  6. Ning Wang#, Fang Le, Xiaozhen Liu, Qitao Zhan, Liya Wang, Jianzhong Sheng, Hefeng Huang, Fan Jin*. Altered expressions and DNA methylation of imprinted genes in chromosome 7 in brain of mouse offspring conceived from in vitro maturation. Reproductive Toxicology. 2012;34(3):420-8. PMID: 22569273.

  7. Yixi Sun#, Jiaojiao Cai, Feng Ma, Pingping Lü, Hefeng Huang, Jun Zhou*. miR-155 mediates suppressive effect of progesterone on TLR3, TLR4-triggered immune response. Immunology Letters. 2012;146(1-2):25-30. PMID: 22546503.

  8. Ye Chun Ruan#, Jing Hui Guo, Xinmei Liu, Runju Zhang, Lai Ling Tsang, Jian Da Dong, Hui Chen, Mei Kuen Yu, Xiaohua Jiang, Xiao Hu Zhang, Kin Lam Fok, Yiu Wa Chung, Hefeng Huang*, Wen Liang Zhou*, Hsiao Chang Chan*. Activation of the epithelial Na+ channel triggers prostaglandin E-2 release and production required for embryo implantation. Nature Medicine. 2012;18(7):1112-7.PMID: 22729284.

  9. Fan Qu#, Fang-Fang Wang, Rong Yin, Guo-Lian Ding, Mohamed El-Prince, Qian Gao, Bi-Wei Shi, Hui-Hui Pan, Yi-Ting Huang, Min Jin, Peter C K Leung, Jian-Zhong Sheng, He-Feng Huang*. A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells. Journal of Molecular Medicine-Jmm. 2012;90(8):911-23. PMID: 22349439.

  10. Yue-hong Lu#, Hui-juan Gao#, Bai-jia Li, Ying-ming Zheng, Ying-hui Ye, Yu-li Qian, Chen-ming Xu, He-feng Huang, Fan Jin*. Different sperm sources and parameters can influence intracytoplasmic sperm injection outcomes before embryo implantation. Journal of Zhejiang University-Science B. 2012;13(1):1-10. PMID: 22205614.

  11. Yong-Chao Lu#, Guo-Lian Ding, Jing Yang, Yan-Ling Zhang, Shuai Shi, Run-Ju Zhang, Dan Zhang, Jie-Xue Pan, Jian-Zhong Sheng, He-Feng Huang*. Small-conductance calcium-activated K+ channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration. Human Reproduction. 2012;27(5):1421-30.PMID: 22416006.

  12. Yong Chao Lu#, Hui Chen#, Kin Lam Fok#, Lai Ling Tsang, Mei Kuen Yu, Xiao Hu Zhang, Jing Chen, Xiaohua Jiang, Yiu Wa Chung, Alvin Chun Hang Ma, Anskar Yu Hung Leung, He Feng Huang*, Hsiao Chang Chan*. CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development. Cell Research. 2012;22(10):1453-66. PMID: 22664907.

  13. Xin-Mei Liu#, Guo-Lian Ding#, Ying Jiang, Hong-Jie Pan, Dan Zhang, Ting-Ting Wang, Run-Ju Zhang, Jing Shu, Jian-Zhong Sheng, He-Feng Huang*. Down-Regulation of S100A11, a Calcium-Binding Protein, in Human Endometrium May Cause Reproductive Failure. Journal of Clinical Endocrinology & Metabolism. 2012;97(10):3672-83. PMID: 22869607.

  14. Min Jin#, YiQi Yu, HeFeng Huang*. An update on primary ovarian insufficiency. Science China-Life Sciences. 2012;55(8):677-86. PMID: 22932883.

  15. Hui-Juan Gao#, Yi-Min Zhu, Wei-Hua He, Ai-Xia Liu, Min-Yue Dong, Min Jin, Jian-Zhong Sheng, He-Feng Huang*. Endoplasmic reticulum stress induced by oxidative stress in decidual cells: a possible mechanism of early pregnancy loss. Molecular Biology Reports. 2012;39(9):9179-86. PMID: 22733488.

  16. Guo-Lian Ding#, Fang-Fang Wang, Jing Shu, Shen Tian, Ying Jiang, Dan Zhang, Ning Wang, Qiong Luo, Yu Zhang, Fan Jin, Peter C K Leung, Jian-Zhong Sheng*, He-Feng Huang*. Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia. Diabetes. 2012;61(5):1133-42. PMID: 22447856.

  17. Shan Dan#, Wei Wang#, Jinghui Ren, Yali Li, Hua Hu, Zhengfeng Xu, Tze Kin Lau, Jianhong Xie, Weihua Zhao, Hefeng Huang, Jiansheng Xie, Luming Sun, Xiaohong Zhang, Weipeng Wang, Shixiu Liao, Rong Qiang, Jiangxia Cao, Qiufang Zhang, Yulin Zhou, Haiyan Zhu, Mei Zhong, Yi Guo, Linhua Lin, Zhiying Gao, Hong Yao, Hongyun Zhang, Lijian Zhao, Fuman Jiang, Fang Chen, Hui Jiang, Songgang Li, Yingrui Li, Jun Wang, Jian Wang, Tao Duan*, Yue Su*, Xiuqing Zhang*. Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors. Prenatal Diagnosis. 2012;32(13):1225-32. PMID: 23138752.

  18. Hui Chen#, Jing Hui Guo, Yong Chao Lu, Guo Lian Ding, Mei Kuen Yu, Lai Ling Tsang, Kin Lam Fok, Xin Mei Liu, Xiao Hu Zhang, Yiu Wa Chung, Pingbo Huang, Hefeng Huang*, Hsiao Chang Chan*. Impaired CFTR-Dependent Amplification of FSH-Stimulated Estrogen Production in Cystic Fibrosis and PCOS. Journal of Clinical Endocrinology & Metabolism. 2012;97(3):923-32. PMID: 22170719.


  1. Li-Bo Zou#, Run-Ju Zhang#, Ya-Jing Tan, Guo-Lian Ding, Shuai Shi, Dan Zhang, Rong-Huan He, Ai-Xia Liu, Ting-Ting Wang, Peter C K Leung, Jian-Zhong Sheng*, He-Feng Huang*. Identification of Estrogen Response Element in the Aquaporin-2 Gene That Mediates Estrogen-Induced Cell Migration and Invasion in Human Endometrial Carcinoma. Journal of Clinical Endocrinology & Metabolism. 2011;96(9):E1399-E408. PMID: 21715543.

  2. Ning Wang#, Liya Wang, Fang Le, Qitao Zhan, Yingming Zheng, Guolian Ding, Xijing Chen, Jianzhong Sheng, Minyue Dong, Hefeng Huang, Fan Jin*. Altered expression of Armet and Mrlp51 in the oocyte, preimplantation embryo, and brain of mice following oocyte in vitro maturation but postnatal brain development and cognitive function are normal. Reproduction. 2011;142(3):401-8. PMID: 21730110.

  3. Jing Shu#, Lili Xing, Lingyan Zhang, Suhua Fang, Hefeng Huang*. Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness. Reproductive Biology and Endocrinology. 2011;9. PMID: 21861901.

  4. Feng-Tao Shi#, Anthony P Cheung, He-Feng Huang, Peter CK Leung*. Growth Differentiation Factor 9 (GDF9) Suppresses Follistatin and Follistatin-Like 3 Production in Human Granulosa-Lutein Cells. Plos One. 2011;6(8). PMID: 21829661.

  5. Fengjuan Liu#, Jing Guo, Ting Tian, Hanzhi Wang, Fanyi Dong, Hefeng Huang, Minyue Dong*. Placental trophoblasts shifted Th1/Th2 balance toward Th2 and inhibited Th17 immunity at fetomaternal interface. Apmis. 2011;119(9):597-604. PMID: 21851417.

  6. Ai-Xia Liu#, Wei-Hua He#, Li-Jun Yin, Ping-Ping Lv, Yu Zhang, Jian-Zhong Sheng, Peter C K Leung, He-Feng Huang*. Sustained Endoplasmic Reticulum Stress as a Cofactor of Oxidative Stress in Decidual Cells from Patients with Early Pregnancy Loss. Journal of Clinical Endocrinology & Metabolism. 2011;96(3):E493-E7. PMID: 21177787.

  7. Lei Li#, Liya Wang, Xiangrong Xu, Hangying Lou, Fang Le, Lejun Li, Jiangzhong Sheng, Hefeng Huang, Fan Jin*. Genome-wide DNA methylation patterns in IVF-conceived mice and their progeny: A putative model for ART-conceived humans. Reproductive Toxicology. 2011;32(1):98-105. PMID: 21672625.

  8. Lei Li#, Liya Wang, Fang Le, Xiaozhen Liu, Ping Yu, Jiangzhong Sheng, Hefeng Huang, Fan Jin*. Evaluation of DNA methylation status at differentially methylated regions in IVF-conceived newborn twins. Fertility and Sterility. 2011;95(6):1975-9. PMID: 21420676.

  9. Lei Li#, Fang Le, Li-ya Wang, Xiang-rong Xu, Hang-ying Lou, Ying-ming Zheng, Jiang-zhong Sheng, He-feng Huang, Fan Jin*. Normal epigenetic inheritance in mice conceived by in vitro fertilization and embryo transfer. Journal of Zhejiang University-Science B. 2011;12(10):796-804. PMID: 21960342.

  10. Chun Feng#, Shen Tian, Yu Zhang, Jing He, Xiao-Ming Zhu, Dan Zhang, Jian-Zhong Sheng, He-Feng Huang*. General imprinting status is stable in assisted reproduction-conceived offspring. Fertility and Sterility. 2011;96(6):1417-U415. PMID: 21982732.


  1. Yu Zhang#Qing HuangJung-Chien ChengYoshihiro NishiToshihiko YanaseHe-Feng Huang*Peter CK Leung*. Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells. Reproductive Biology and Endocrinology. 2010,8:61.PMID: 20540809.

  2. Dan Zhang#Yimin ZhuHuijuan GaoBiao ZhouRunju ZhangTingting WangGuolian DingFan QuHefeng Huang*Xiue Lu. Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women. Gynecological Endocrinology. 2010;26(5):325-32. PMID: 20192898.

  3. Yao WM#, Wang JM, Huang HF, Ye YH*. Prenatal diagnosis of double aortic arch and D-transposition of the great arteries: a case report. Prenatal Diagnosis. 2010;30(4):382-3. PMID: 20155782.

  4. Ting-Ting Wang#Yan-Ting WuMin-Yue DongJian-Zhong ShengPeter CK LeungHe-Feng Huang*. G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve. Fertility and Sterility. 2010;94(6):2490-2. PMID: 20451184.

  5. Feng-Tao Shi#Anthony P Cheung#Christian KlausenHe-Feng HuangPeter C K Leung*. Growth Differentiation Factor 9 Reverses Activin A Suppression of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Human Granulosa-Lutein Cells. Journal of Clinical Endocrinology & Metabolism. 2010;95(10):E172-E80.PMID: 20660033.

  6. Feng-Tao Shi#Anthony P CheungHe-Feng HuangPeter C K Leung*. Growth differentiation factor 9 (GDF9) suppresses follistatin and follistatin-like 3 production in human granulosa-lutein cells. PLoS One. 2011;6(8):e22866. PMID: 21829661.

  7. Fan Qu#Fang-Fang Wang#Xiu-E LuMin-Yue DongJian-Zhong ShengPing-Ping LvGuo-Lian DingBi-Wei ShiDan ZhangHe-Feng Huang*. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. Human Reproduction. 2010;25(6):1441-50. PMID: 20378617.

  8. Qiong Luo#Xi-Jing ChenGuo-Lian DingMing-Yue DongHe-Feng Huang*. Downregulative Effects of Nitric Oxide on Oocyte Fertilization and Embryo Development: Possible Roles of Nitric Oxide in the Pathogenesis of Endometriosis-associated Infertility. Cellular Physiology and Biochemistry. 2010;26(6):1023-8. PMID: 21220933.

  9. Guo-Lian Ding#Xi-Jing ChenQiong LuoMin-Yue DongNing WangHe-Feng Huang*. Attenuated oocyte fertilization and embryo development associated with altered growth factor/signal transduction induced by endometriotic peritoneal fluid. Fertility and Sterility. 2010;93(8):2538-44. PMID: 20045520.

  10. Min Hui Chen#, Hui Chen#, Zhen Zhou#, Ye Chun Ruan, Hau Yan Wong, Yong Chao Lu, Jing Hui Guo, Yiu Wa Chung, Ping Bo Huang, He Feng Huang, Wen Liang Zhou*, Hsiao Chang Chan*. Involvement of CFTR in oviductal HCO3- secretion and its effect on soluble adenylate cyclase-dependent early embryo development. Human Reproduction. 2010;25(7):1744-54. PMID: 20406739.


  1. Yinghui Ye#Chenming XuYuli QianFan JinHefeng Huang*. Evaluation of human sperm function after being cryopreserved within the zona pellucida. Fertility and Sterility. 2009;92(3):1002-8. PMID: 18829001.

  2. Chenming Xu#, Jian Xu*, Huijuan Gao, Hefeng Huang. Triplet pregnancy and successful twin delivery in a patient with congenital cervical atresia who underwent transmyometrial embryo transfer and multifetal pregnancy reduction. Fertility and Sterility. 2009;91(5). PMID:19264303.

  3. Chenming Xu#Bingsen XuHefeng HuangXuefeng HuangFan Jin*. Preimplantation genetic diagnosis for X-linked agammaglobulinemia: a case report. Fertility and Sterility. 2009 ,91(5):1958.e5-7. PMID: 19268935.

  4. Li Tang#, Yu Zhang#, Hong Pan, Qiong Luo, Xiao-Ming Zhu, Min-Yue Dong, Peter Ck Leung, Jian-Zhong Sheng*, He-Feng Huang*. Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell. Reproductive Biology and Endocrinology. 2009;7. PMID: 19968870.

  5. Li Tang#Ting-Ting WangYan-Ting WuCai-Yun ZhouHe-Feng Huang*. High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis. Fertility and Sterility. 2009;91(4):979-87. PMID: 18353325.

  6. Li Su#Yixi SunFeng MaPingping LüHefeng HuangJun Zhou*. Progesterone inhibits Toll-like receptor 4-mediated innate immune response in macrophages by suppressing NF-kappa B activation and enhancing SOCS1 expression. Immunology Letters. 2009;125(2):151-5. PMID: 19607861.

  7. Feng-Tao Shi#, Anthony P Cheung, He-Feng Huang, Peter C K Leung*. Effects of Endogenous Growth Differentiation Factor 9 on Activin A-Induced Inhibin B Production in Human Granulosa-Lutein Cells. Journal of Clinical Endocrinology & Metabolism. 2009;94(12):5108-16. PMID: 19846738.

  8. Fan Qu#, Xuefen Cai, Yinger Gu, Jue Zhou, Runju Zhang, Elizabeth Burrows, Hefeng Huang*. Chinese Medicinal Herbs in Relieving Perimenopausal Depression: A Randomized, Controlled Trial. Journal of Alternative and Complementary Medicine. 2009;15(1):93-100. PMID: 19769482.

  9. Ming-fang Miao#He-feng Huang*. Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment. Journal of Zhejiang University-Science B. 2009;10(1):35-45. PMID: 19198021.

  10. Qing Huang#, Anthony P Cheung, Yu Zhang, He-Feng Huang, Nelly Auersperg, Peter C K Leung*. Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation. American Journal of Physiology-Endocrinology and Metabolism. 2009, 296(6): E1344-E53. PMID: 19366876.

  11. Chun Feng#Li-Quan WangMin-Yue DongHe-Feng Huang*. Assisted Reproductive Technology May Increase Clinical Mutation Detection in Male Offspring Editorial Comment. Journal of Urology. 2009;181(4):1828-9. PMID: 18258231.


  1. Xiao-Ming Zhu#, Yi-Min Zhu, Chen-Ming Xu, Yu-Li Qian, Fan Jin, He-Feng Huang*. Autologous mature follicular fluid: its role in in vitro maturation of human cumulus-removed oocytes. Fertility and Sterility. 2008;90(4):1094-102. PMID: 18001728.

  2. Yu Zhang#, Yan-Ling Zhang#, Chun Feng, Yan-Ting Wu, Ai-Xia Liu, Jian-Zhong Sheng, Jie Cai, He-Feng Huang*. Comparative proteomic analysis of human placenta derived from assisted reproductive technology. Proteomics. 2008;8(20):4344-56. PMID: 18792929.

  3. Bo Wang#, Jian-Zhong Sheng, Rong-Huan He, Yu-Li Qian, Fan Jin, He-Feng Huang*. High expression of L-selectin ligand in secretory endometrium is associated with better endometrial receptivity and facilitates embryo implantation in human being. American Journal of Reproductive Immunology. 2008;60(2):127-34. PMID: 18573129.

  4. Fan Qu#, Jue Zhou, Hefeng Huang*. Treating Adolescent Ovarian Cysts with Chinese Herbs: A Case Report. Phytotherapy Research. 2008;22(12):1682-3. PMID: 19003893.

  5. Fan Qu#Jue ZhouElizabeth BurrowsQiong LuoYanting WuTingting WangHefeng Huang*. Acupuncture May Improve the Absorption of Baicalin from the Extracts of Scutellaria baicalensis Georgi in Rats with Pelvic Inflammation. Forschende Komplementarmedizin. 2008;15(5):282-5. PMID: 19001827.

  6. Yu-li Qian#, Ying-hui Ye, Chen-ming Xu, Fan Jin, He-feng Huang*. Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF. Journal of Zhejiang University-Science B. 2008;9(8):649-55. PMID: 18763315.

  7. Hong Pan#Chao-Chao Sun#Cai-Yun ZhouHe-Feng Huang*. Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria. International Journal of Gynecology & Obstetrics. 2008,101(3):239-44. PMID: 18313673.

  8. Hong Pan#, Jian-Zhong Sheng, Li Tang, Rong Zhu, Tian-Hua Zhou, He-Feng Huang*. Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients. Fertility and Sterility. 2008;90(4):1000-7. PMID: 17888430.

  9. Qing-Xia Meng#, Hui-Juan Gao#, Chen-Ming Xu, Min-Yue Dong, Xia Sheng, Jian-Zhong Sheng, He-Feng Huang*. Reduced expression and function of aquaporin-3 in mouse metaphase-II oocytes induced by controlled ovarian hyperstimulation were associated with subsequent low fertilization rate. Cellular Physiology and Biochemistry. 2008;21(1-3):123-8. PMID: 18209479.

  10. Zhong-Xiang Li#Ting-Ting WangYan-Ting WuChen-Ming XuMin-Yue DongJian-Zhong ShengHe-Feng Huang*. Adriamycin induces H2AX phosphorylation in human spermatozoa. Asian Journal of Andrology. 2008;10(5):749-57. PMID: 18645678.

  11. Zhongxiang Li#, Hefeng Huang*. Epigenetic abnormality: A possible mechanism underlying the fetal origin of polycystic ovary syndrome. Medical Hypotheses. 2008;70(3):638-42. PMID: 17764855.

  12. Wensheng Hu#Zhengping WangHanzhi WangHefeng HuangMinyue Dong*. Serum visfatin levels in late pregnancy and pre-eclampsia. Acta Obstetricia Et Gynecologica Scandinavica. 2008,87(4):413-8. PMID: 18382866.

  13. Chun Feng#Li-Quan WangMin-Yue DongHe-Feng Huang*. Assisted reproductive technology may increase clinical mutation detection in male offspring. Fertility and Sterility. 2008;90(1):92-6. PMID: 18258231.

  14. Chun Feng#, Chao-Chao Sun#, Ting-Ting Wang, Rong-Huan He, Jian-Zhong Sheng, He-Feng Huang*. Decreased expression of endometrial vessel AQP1 and endometrial epithelium AQP2 related to anovulatory uterine bleeding in premenopausal women. Menopause-the Journal of the North American Menopause Society. 2008;15(4):648-54. PMID: 18463544.

  15. Minyue Dong#Guolian DingJun ZhouHanzhi WangYi ZhaoHefeng Huang*. The effect of trophoblasts on T lymphocytes: Possible regulatory effector molecules - A proteomic analysis. Cellular Physiology and Biochemistry. 2008;21(5-6):463-72. PMID: 18453754.

  16. Danqing Chen#, Hanzhi Wang, Hefeng Huang, Minyue Dong*. Vascular endothelial growth factor attenuates N omega-Nitro-L-arginine Methyl Ester-induced preeclampsia-like manifestations in rats. Clinical and Experimental Hypertension. 2008;30(7):606-15. PMID: 18855264.


  1. Song-ying Zhang#*He-feng HuangXiao-mei Tong. Solitary luteinized follicle cyst of pregnancy complicated with persistent postpartum vaginal bleeding: case report. Chinese Medical Journal. 2007,120(3):257-8. PMID: 17355835.

  2. Yan-Ting Wu#, Li Tang#, Jie Cai, Xiu-E Lu, Jian Xu, Xiao-Ming Zhu, Qiong Luo, He-Feng Huang*. High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development. Human Reproduction. 2007,22(6):1526-31. PMID: 17347167.

  3. Ya Ni#, Kun Li, Wanxiang Xu, Liwen Song, Kangshou Yao, Xinzong Zhang, Hefeng Huang, Yanling Zhang, Qi-Xian Shi*. Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a(22 similar to 176) and rhuZP3b(177 similar to 348) and their mechanism. Journal of Andrology. 2007, 28(3):381-8. PMID: 17192598.

  4. Shiming Lu#Hanzhi WangYaping ShiYali SunHefeng HuangMinyue Dong*. Serum IL-16, not IL-15, was elevated in early second trimester of pregnancy in women who subsequently developed preeclampsia. Clinica Chimica Acta. 2007,383(1-2):175-7. PMID: 17537415.

  5. Ai-Xia Liu#Yi-Min ZhuQiong LuoYan-Ting WuHui-Juan GaoXiao-Ming ZhuChen-Ming XuHe-Feng Huang*. Specific peptide patterns of follicular fluids at different growth stages analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Biochimica Et Biophysica Acta-General Subjects. 2007,1770(1):29-38. PMID: 16949757.

  6. Mei-Gen Li#Guo-Lian Ding#Xi-Jing ChenXi-Ping LuLi-Jun DongMin-Yue DongXiao-Fu YangXiu-E LuHe-Feng Huang*. Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome. Journal of Clinical Endocrinology & Metabolism. 2007,92(12):4771-6. PMID: 17895321.

  7. Wensheng Hu#Hanzhi WangZhengping WangHefeng HuangMinyue Dong*. Elevated serum levels of interleukin-15 and interleukin-16 in preeclampsia. Journal of Reproductive Immunology. 2007,73(2):166-71. PMID: 16938352.

  8. Minyue Dong#Hanzhi WangHefeng Huang*. Alterations of serum cathepsins B and L in pre-eclampsia. Clinica Chimica Acta. 2007,377(1-2):285-7. PMID: 17094954.

  9. Jung-Hye Choi#Alice S T WongHe-Feng HuangPeter CK Leung*. Gonadotropins and ovarian cancer. Endocrine Reviews. 2007,28(4):440-61. PMID: 17463396.

  10. Danqing Chen#Qin FangYun ChaiHanzhi WangHefeng HuangMinyue Dong*. Serum resistin in gestational diabetes mellitus and early postpartum. Clinical Endocrinology. 2007,67(2):208-11. PMID: 17547683.

  11. Jie Cai#Hang-ying LouMin-yue DongXiu-e LuYi-min ZhuHui-juan GaoHe-feng Huang*. Poor ovarian response to gonadotropin stimulation is associated with low expression of follicle-stimulating hormone receptor in granulosa cells. Fertility and Sterility. 2007,87(6):1350-6. PMID: 17296182.


  1. Heng-Chao Ruan#Xiao-Ming Zhu#Qiong LuoAi-Xia LiuYu-Li QianCai-Yun ZhouFan JinHe-Feng Huang*Jian-Zhong Sheng. Ovarian stimulation with GnRH agonist, but not GnRH antagonist, partially restores the expression of endometrial integrin beta3 and leukaemia-inhibitory factor and improves uterine receptivity in mice. Human Reproduction. 2006,21(10):2521-9. PMID: 16790614.

  2. Hong Wei Ouyang#Tong CaoXiao Hui ZouBoon Chin HengLing Ling WangXing Hui SongHe Feng Huang*. Mesenchymal stem cell sheets revitalize nonviable dense grafts: Implications for repair of large-bone and tendon defects. Transplantation. 2006,82(2):170-4. PMID: 16858278.

  3. Qiong Luo#Jun YangQun-Li ZengXiao-Ming ZhuYu-Li QianHe-Feng Huang*. 50-Hertz electromagnetic fields induce gammaH2AX foci formation in mouse preimplantation embryos in vitro. Biology of Reproduction. 2006;75(5):673-80. PMID: 16855210.

  4. Qiong Luo#Weixuan Ning#Yanting WuXiaoming ZhuFan JinJianzhong ShengHefeng Huang*. Altered expression of interleukin-18 in the ectopic and eutopic endometrium of women with endometriosis. Journal of Reproductive Immunology. 2006;72(1-2):108-17.PMID: 16963127.

  5. Xiu-E Lu#Wei-Xuan NingMin-Yue DongAi-Xia LiuFan JinHe-Feng Huang*. Vascular endothelial growth factor and matrix metalloproteinase-2 expedite formation of endometriosis in the early stage ICR mouse model. Fertility and Sterility. 2006;86:1175-81.PMID: 16962110.

  6. Donghong Lu#Xiaofu YangYuzhong WuHanzhi WangHefeng HuangMinyue Dong*. Serum adiponectin, leptin and soluble leptin receptor in pre-eclampsia. International Journal of Gynecology & Obstetrics. 2006;95(2):121-6.PMID: 16919629.

  7. Ai-Xia Liu#Fan JinWu-Wen ZhangTian-Hua ZhouCai-Yun ZhouWei-Miao YaoYu-Li QianHe-Feng Huang*. Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss. Biology of Reproduction. 2006,75(3):414-20. PMID: 16738225.

  8. Zhongxiang Li#Jun YangHefeng Huang*. Oxidative stress induces H2AX phosphorylation in human spermatozoa. Febs Letters. 2006;580(26):6161-8.PMID: 17064697.

  9. Zhongxiang Li#Liquan WangJie CaiHefeng Huang*. Correlation of sperm DNA damage with IVF and ICSI outcomes: A systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics. 2006;23(9-10):367-76. PMID: 17019633.

  10. Li Jin#Xiao-Ming ZhuQiong LuoYuli QianFan JinHe-Feng Huang*. A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS. Molecular Human Reproduction. 2006,12(3):151-5. PMID: 16510536.

  11. He-Feng Huang*, Rong-Huan HeChao-Chao SunYu ZhangQing-Xia MengYing-Ying Ma. Function of aquaporins in female and male reproductive systems. Human Reproduction Update. 2006,12(6):785-95.PMID: 16840793.

  12. Rong-Huan He#Jian-Zhong ShengQiong LuoFan JinBo WangYu-Li QianCai-Yun ZhouXia ShengHe-Feng Huang*. Aquaporin-2 expression in human endometrium correlates with serum ovarian steroid hormones. Life Sciences. 2006;79(5):423-9.PMID: 16483614.


  1. Li-Quan Wang#He-Feng Huang*Fan JinYu-Li QianQi Cheng. High frequency of Y chromosome microdeletions in idiopathic azoospermic men with high follicle-stimulating hormone levels. Fertility and Sterility. 2005;83(4):1050-2.PMID: 15820827.

  2. Min Jin#Fan JinLi ZhangZhong ChenHefeng Huang*.Two estrogen replacement therapies differentially regulate expression of estrogen receptors alpha and beta in the hippocampus and cortex of ovariectomized rat. Brain research. Molecular brain research, 2005,142(2), 107–114. PMID: 16290139.

  3. Xiadi Huang#Hefeng Huang*Minyue DongQiwei YaoHanzhi Wang. Serum and placental interleukin-18 are elevated in preeclampsia. Journal of Reproductive Immunology. 2005;65(1):77-87. PMID: 15694969.


  1. He-Feng Huang#Bo WangXiao-Fu YangQiong LuoJian-Zhong Sheng*. Nitric oxide mediates inhibitory effect of leptin on insulin-like growth factor I augmentation of 17 beta-estradiol production in human granulosa cells. Biology of Reproduction. 2005;72(1):102-6. PMID: 15371274.

  2. 1.He-Feng Huang*, Li-Hua HongYi TanJian-Zhong Sheng. Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis. Fertility and Sterility. 2004;81(5):1235-9. PMID: 15136083.


  1. 1.Barbara S Kisilevsky#Sylvia M J HainsKang LeeXing XieHefeng HuangHai Hui YeKe ZhangZengping Wang*. Effects of experience on fetal voice recognition. Psychological Science. 2003;14(3):220-4. PMID: 12741744.