林仙华

基本信息

姓名：

林仙华

职称：

主任医师

导师类型：

硕士生导师

专业：

妇产科

研究方向：

生殖内分泌方向

邮箱地址：

xl_1290@126.com

个人简介

林仙华，副主任医师，硕士生导师，生殖内分泌博士，英国伦敦大学国王学院神经内分泌专业荣誉博士后，上海市医苑新星杰出青年医学人才。上海市医苑新星杰出青年医学人才。现担任上海市医学会妇产科分会内分泌学组副组长，中国医疗保健交流促进会生殖医学分会委员，国家卫检委能力建设和继续教育中心《妇科内分泌诊疗体系及健康教育研究》课题秘书,上海市中西医结合学会生殖分会委员。以共同完成人分别获得2015年度全国妇幼健康科学技术科技成果一等奖和2020年度上海市科技成果一等奖。主持国家自然科学基金2项及省部级项目多项，作为研究骨干参与国家重大科研项目3项，以第一作者和通讯作者发表Hypertension等SCI论文14篇。

主要科研项目

1. 中国女性早绝经的风险预测及应用研究，国家重点研发计划，2022YFC2703801，研究骨干。

2. 母体内分泌代谢对子代生命早期健康的影响及关键机制研究，国家重点研发计划，2021YFC2700701，研究骨干。

3. 胚胎植入前遗传学筛查技术在严重少弱精子症不育夫妇中应用的随机对照临床研究，复旦大学附属妇产科医院临床研究面上项目，项目负责人

4. 下丘脑室旁核GABA受体介导母体免疫激活致子代HPA轴功能紊乱的表观遗传机制研究，国家自然科学基金面上项目，82071730，项目负责人

5. 辅助生殖的表观遗传安全性研究，国家重点研发计划，2018YFC1005001，研究骨干

6. 脂肪酸调控TET1介导血管内皮细胞去甲基化的代间效应及机制研究，国家自然科学基金青年项目，81501340，项目负责人

7. 羟氯喹预处理对改善多囊卵巢综合征患者妊娠结局的疗效评估，上海申康发展中心临床培育项目，SHDC12019X17，项目负责人

代表性论文（^#第一作者，*通讯作者）

1. Dandan Wu^#, Jianlin Zhang^#, Yimeng Xiong^#, Hui Wang, Danyang Lu, Mengxi Guo, Jian Zhang, Lei Chen, Jianxia Fan, Hefeng Huang* and Xianhua Lin*. Effect of Maternal Glucose and Triglyceride Levels during Early Pregnancy on Pregnancy Outcomes: A Retrospective Cohort Study.Nutrients. 2022 Aug 11;14(16):3295.

2. Xian-hua Lin^#,Meng-xi Guo^#,Dan-dan Wu^#,Yao Lu^#, Jian-lin Zhang,Cheng-liang Zhou,Li Jin,Li Wang, Chen Zhang, Chen-ming Xu, Song-chang Chen,Song-ying Zhang,Xiao-xi Sun,Yan-ting Wu ,Yun Sun,He-feng Huang. Preimplantation genetic testing for aneuploidy in severe male factor infertility: protocol for a multicenter randomised controlled trial. BMJ Open. 2022 Jul 13;12(7):e063030.

3. Xian-Hua Lin, Geffen Lass, Ling-Si Kong, Hui Wang, Xiao-Feng Li, He-Feng Huang, Kevin T. O’Byrne. Optogenetic activation of arcuate kisspeptin neurons generates a luteinizing hormone surge-like secretion in an estradiol-dependent manner. Front Endocrinol (Lausanne). 2021 Nov 2;12:775233.

4. Xia-fei Jiang#, Hui Wang#, Dan-dan Wu1#, Jian-lin Zhang, Ling Gao, Lei Chen, Jian Zhang, Jian-xia Fan, He-feng Huang*, Yan-ting Wu*, Xian-hua Lin*. The Impact of Gestational Weight Gain on the Risks of Adverse Maternal and Infant Outcomes Among Normal BMI Women with High Triglyceride Levels During Early Pregnancy. Nutrients. 2021 Sep 29;13(10):3454.

5. Xiang-Juan Li# , Hui Wang# , Dan-Yang Lu, Tian-Tian Yu, Kamran Ullah, Xin-Yan Shi, Yong-Hai Shen, Xiao-Yang Fei, Zhen-Yun Lin , He-Feng Huang , Xian-Hua Lin*. Anti-Müllerian Hormone Accelerates Pathological Process of Insulin Resistance in Polycystic Ovary Syndrome Patients. Horm Metab Res. 2021 Aug;53(8):504-511.

6. Xian-Hua Lin#,  Ling Gao#, Shen Tian#, Christian Klausen , Meng-Xi Guo , Qian Gao , Miao-E Liu , Hui Wang , Dan-Dan Wu , Cheng-Liang Zhou , Jing Yang , Ye Meng , Ye Liu , Gu-Feng Xu , Ya-Jing Tan , Kamran Ullah , Yi-Min Zhu , William D Fraser , Jian-Zhong Sheng , Peter C K Leung , Louis J Muglia, Yan-Ting Wu*, He-Feng Huang*. Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring. Sci Rep; 2021 Jan 11;11(1):316.

7. Rui-hong Xue#, Dan-dan Wu#, Cheng-liang Zhou, Lei Chen, Juan Li, Zheng-zheng Li, Jian-xia Fan, Xin-mei Liu, Xian-hua Lin*, He-feng Huang*. Association of high maternal triglyceride levels early and late in pregnancy with adverse outcomes: A retrospective cohort study. J Clin Lipidol; Jan-Feb 2021;15(1):162-172. (IF 4.766)

8. Ling Gao#, Dandan Wu#, Yanting Wu, Zuwei Yang, Jianzhong Sheng, Xianhua Lin*, and Hefeng Huang*. MiR-3940-5p promotes granulosa cell proliferation through targeting KCNA5. Biochem Biophys Res Commun. 2020 Apr 16;524(4):791-797.

9. Wu DD#, Gao L#, Huang O#, Ullah K, Guo MX, Liu Y, Zhang J, Chen L, Fan JX, Sheng JZ, Lin XH*, Huang HF*. Increased Adverse Pregnancy Outcomes Associated With Stage 1 Hypertension in a Low-Risk Cohort: Evidence From 47 874 Cases. Hypertension. 2020 Mar;75(3):772-780.

10. Lin XH, Wu DD, Li C, Xu YJ, Gao L, Lass G, Zhang J, Tian S, Ivanova D, Tang L, Chen L, Ding R, Liu XM, Han M, Fan JX, Li XF, Sheng JZ, O'Byrne KT, Huang HF*. Maternal High Triglyceride Levels During Early Pregnancy and Risk of Preterm Delivery: A Retrospective Cohort Study. J Clin Endocrinol Metab. 2019 Apr 1;104(4):1249-1258.

11. Lin XH^#, Wang H^#, Wu DD, Ullah K, Yu TT, Ur Rahman T, Huang HF. High Leptin Level Attenuates Embryo Development in Overweight/Obese Infertile Women by Inhibiting Proliferation and Promotes Apoptosis in Granule Cell. Horm Metab Res. 2017, 49 (7) :534-541.

12. Xian-Hua Lin^#, Miao-E Liu^#, Hai-Yan Xu^#, Xue-Jun Chen, Hui Wang, Shen Tian, Jian-Zhong Sheng, and He- Feng Huang. Leptin down-regulates γ-ENaC expression: a novel mechanism involved in low endometrial receptivity. Fertility and Sterility. 2015 Jan;103(1):228-235.

13. Tian S^#, Lin XH^#, Xiong YM^#, Liu ME, Yu TT, Lv M, Zhao W, Xu GF,… He- Feng Huang. Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism. EBioMedicine. 2017 Feb; 16:275-283.

14. Gao L^#, Zhao YC^#, Liang Y^#, Lin XH^#, Tan YJ, Wu DD, Li XZ, Ye BZ, Kong FQ, Sheng JZ, Huang HF. The impaired myocardial ischemic tolerance in adult offspring of diabetic pregnancy is restored by maternal melatonin treatment. J Pineal Res. 2016 Oct; 61(3):340-52.

代表性著作

1.发育源性疾病，专著，2022年，人民卫生出版社，参编

获奖

1. 发育源性疾病和遗传性出生缺陷的机制研究及临床精准防控，上海市科技进步一等奖，第九完成人，2020年。

2. 生殖过程调控与相关疾病分子机理，中国妇幼保健全国妇幼健康科学技术科技成果一等奖，第十二完成人，2015年。