丁国莲

基本信息

姓名：

丁国莲

职称：

主任医师/ 副教授

导师类型：

博士生导师

专业：

生殖医学

研究方向：

配子胚胎源性疾病

邮箱地址：

dingguolian@fudan.edu.cn

个人简介

复旦大学附属妇产科医院/生殖与发育研究院，主任医师、副教授、博士生导师，中组部国家青年拔尖人才。美国Baylor College of Medicine访问学者。从事生殖医学临床、科研及教学工作，聚焦发育源性疾病研究，以第一/通讯作者（含共同）在Nature，Advanced Science，Diabetes等发表论文，为源头防控糖尿病等慢病提供科学依据及干预策略，助力母婴保健及人口健康，部分成果入选中国2021重要医学进展（基础医学与生物学领域）。作为主要完成人荣获国家科技进步二等奖、上海市科技进步一等奖、全国妇幼健康科技成果奖一等奖；入选上海市人才发展资金资助计划、上海市卫生系统优秀青年医学人才培养计划，获上海市卫生系统“银蛇奖”，上海“医树奖”青年科技创新奖。

主要科研项目

1. 孕期糖脂代谢风险干预防控胚胎源性疾病的关键技术研究，国家重点研发计划子课题，2022YFC2703503，课题负责人

2. 精子miRNA介导的父系节律紊乱致子代认知异常的机制研究，国家自然科学基金面上项目，82271722，项目负责人

3. 宫内高糖环境对TET介导的子代胰岛细胞去甲基化的影响及机制研究，国家自然基金面上项目，81971458， 项目负责人

4. 雌激素对Pax8介导的子代甲状腺发育及功能的影响机制研究，国家自然基金面上项目，31571556， 项目负责人

5. 宫内高糖环境对雄性子代生殖细胞Igf2/H19基因印记的影响及其机制研究，国家自然基金青年项目，81200485，项目负责人

6. 宫内高糖环境致胚胎源性认知异常的分子机制，上海市卫生系统优秀青年医学人才培养计划，2017YQ047，项目负责人

7. 重大出生缺陷中基因突变致病性的系统识别及其非经典致病机制解析，国家重点研发计划项目，2021YFC2701100，课题骨干

8. 人类胚胎发育中的细胞编程与配子/胚胎源性疾病的发生机制，国家重点研发计划项目，2017YFC1001300，课题骨干

代表性论文（^#第一作者，*通讯作者）

1. Ding GL#, Li X#, Hou XG#, Zhou WJ#, Gong YY, Liu FQ, He YL, Song J, Wang J, Basil P, Li WB, Qian SC, Saha P, Wang JB, Cui C, Yang TT, Zou KX, Han YH, Amos C I., Xu Y, Chen L*, Sun Z*. REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity. Nature. 2021;592(7856):763-767

2. Chen B#, Du YR#, Zhu H#, Sun ML#, Wang C#, Cheng Y, Pang H, Ding G, Gao J, Tan Y, Tong X, Lv P, Zhou F, Zhan Q, Xu ZM, Wang L, Luo D, Ye Y, Jin L, Zhang S, Zhu Y, Lin X, Wu Y, Jin L, Zhou Y, Yan C, Sheng J, Flatt PR, Xu GL*, Huang H*. Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency. Nature. 2022;605(7911):761-766

3. Gong YY#, Xue YF#, Li X, Zhang Z, Zhou WJ, Marcolongo P, Benedetti A, Mao SY, Han L, Ding GL*, Sun Z*. Inter- and Transgenerational Effects of Paternal Exposure to Inorganic Arsenic. Adv Sci. 2021;8(7):2002715

4. Ding GL, Chen B, McCarrey JR, Huang HF. The epigenetic mechanisms underlying gamete origin of adult-onset diseases. Science Bulletin. 2022, Sep 15; 67(17):1724-1727

5. Luo SS, Zhu H, Huang HF, Ding GL*. Sex differences in glycolipidic disorders after exposure to maternal hyperglycemia during early development. J Endocrinol Invest. 2023 Mar 28. doi: 10.1007/s40618-023-02069-5. Online ahead of print

6. Li XY, Pan JX, Zhu H, Ding GL*, Huang HF*. Environmental epigenetic interaction of gametes and early embryos. Biol Reprod. 2022;107(1):196-204

7. Luo SS#, Zou KX#, Zhu H, Cheng Y, Yan YS, Sheng JZ, Huang HF*, Ding GL*. Integrated Multi-Omics Analysis Reveals the Effect of Maternal Gestational Diabetes on Fetal Mouse Hippocampi. Front Cell Dev Biol. 2022;10:748862

8. Zhu H#, Chen B#, Cheng Y, Zhou Y, Yan YS, Luo Q, Jiang Y, Sheng JZ, Ding GL*, Huang HF*. Insulin Therapy for Gestational Diabetes Mellitus Does Not Fully Protect Offspring From Diet-Induced Metabolic Disorders. Diabetes. 2019;68(4):696-708 

9. Zou K#, Ren J#, Luo S, Zhang J, Zhou C, Tan C, Lv P, Sun X, Sheng J, Liu X, Huang H*, Ding G*. Intrauterine hyperglycemia impairs memory across two generations. Transl Psychiatry. 2021;11(1):434

10. Jiang Z#, Zou K#, Liu X, Gu H, Meng Y, Lin J, Shi W, Yu C, Jin L, Wang L, Liu X, Sheng J, Huang H*, Ding G*. Aging attenuates the ovarian circadian rhythm. J Assist Reprod Genet. 2021;38(1):33-40

11. Jiang Z#, Jin L#, Shi W, Xi J, Hu Y, Liu X, Sheng J, Ding G*, Huang H*. A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis. Sci China Life Sci. 2019;62(1):112-118

12. Gong Y, Liu J, Xue Y, Zhuang Z, Qian S, Zhou W, Li X, Qian J, Ding G*, Sun Z*. Non-monotonic dose-response effects of arsenic on glucose metabolism. Toxicol Appl Pharmacol. 2019;377:114605

13. Zhou W#, He Y#, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton JEV; DDD study, Hou X, Wu Q, Tong Q, Liu Z, Liu P*, Xu Y*, Sun Z*. Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019;22(2):205-217

14. Zou K#, Ding G#, Huang H*. Advances in research into gamete and embryo-fetal origins of adult diseases. Sci China Life Sci. 2019;62(3):360-368.

15. Ding G, Gong Y, Eckel-Mahan KL*, Sun Z*. Central Circadian Clock Regulates Energy Metabolism. Adv Exp Med Biol. 2018;1090:79-103.

16. Hong S#, Zhou W#, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA*, Sun Z*. Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med. 2017;23(2):223-234.

17. Ding GL#, Liu Y#, Liu ME, Pan JX, Guo MX, Sheng JZ, Huang HF. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Asian J Androl. 2015; 17(6):948-953

18. Liu XM#, Chan HC#, Ding GL#, Cai J, Song Y, Wang TT, Zhang D, Chen H, Yu MK, Wu YT, Qu F, Liu Y, Lu YC, Adashi EY, Sheng JZ*, Huang HF*. FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+) /CREB pathway. Aging Cell. 2015;14(3):409-420

19. Lv PP#, Meng Y#, Lv M, Feng C, Liu Y, Li JY, Yu DQ, Shen Y, Hu XL, Gao Q, Dong S, Lin XH, Xu GF, Tian S, Zhang D, Zhang FH, Pan JX, Ye XQ, Liu ME, Liu XM, Sheng JZ, Ding GL*, Huang HF*. Altered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of pregnancy: a cross-sectional study. BMC Med. 2014;12(1):240.

20. Ding GL, Huang HF*. Role for tet in hyperglycemia-induced demethylation: a novel mechanism of diabetic metabolic memory. Diabetes. 2014;63(9):2906-2908

21. Ding GL, Huang HF*. Paternal transgenerational glucose intolerance with epigenetic alterations in second generation offspring of GDM. Asian J Androl. 2013;15(4):451-452

22. Liu XM#, Ding GL#, Jiang Y, Pan HJ, Zhang D, Wang TT, Zhang RJ, Shu J, Sheng JZ*, Huang HF*. Down-Regulation of S100A11, a Calcium-Binding Protein, in Human Endometrium May Cause Reproductive Failure. J Clin Endocrinol Metab. 2012;97(10):3672-3683

23. Ding GL#, Wang FF#, Shu J, Tian S, Jiang Y, Zhang D, Wang N, Luo Q, Zhang Y, Jin F, Leung PC, Sheng JZ*, Huang HF*. Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes. 2012;61(5):1133-1142

24. Ding GL#, Chen XJ#, Luo Q, Dong MY, Wang N, Huang HF*. Attenuated oocyte fertilization and embryo development associated with altered growth factor/signal transduction induced by endometriotic peritoneal fluid. Fertil Steril. 2010;93(8): 2538-2544

25. Li MG#, Ding GL#, Chen XJ, Lu XP, Dong LJ, Dong MY, Yang XF, Lu XE, Huang HF*. Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome. J Clin Endocrinol Metab. 2007;92(12): 4771-4776

代表性著作

1. He-Feng Huang, Guo-Lian Ding, Shen Tian, and Qiong Luo. Gamete and Embryo-fetal Origins of Adult Diseases (Chapter 4, Gamete/Embryo-Fetal Origins of Diabetes), Springer, 2013

2. He-Feng Huang, Guo-Lian Ding, Xin-Mei Liu, and Zi-Ru Jiang. The Intergenerational Effects on Fetal Programming (Chapter16, Human Reproductive and Prenatal Genetics), ELSEVIER / Academic Press, 2018

3. Guolian Ding, Yingyun Gong, Kristin L Eckel-Mahan, and Zheng Sun. Central Circadian Clock Regulates Energy Metabolism (Chapter 5, Neural Regulation of Metabolism), Springer, 2018

4. 实用人类辅助生殖技术，2018，人民卫生出版社，参编

5. 发育源性疾病，2022，人民卫生出版社，参编

获奖

1. 发育源性疾病和遗传性出生缺陷的机制研究及临床精准防控，中华人民共和国国务院，国家科学技术进步奖二等奖，第三完成人，2020年

2. 发育源性疾病和遗传性出生缺陷的机制研究及临床精准防控，上海市人民政府，上海市科技进步奖一等奖，第四完成人，2019年

3. 生殖过程调控及相关疾病分子机理，妇幼健康研究会，全国妇幼健康科学技术奖科技成果奖一等奖，第九完成人，2015年