个人简介(300字) 妇产科学博士,副教授,副主任医师,硕士生导师;上海市生殖与发育重点实验室秘书 专业特长:从事生殖内分泌及生殖遗传临床工作。重点关注育龄期女性常见的内分泌疾病--多囊卵巢综合征(PCOS)女性孕前、孕期的内分泌代谢状态,除此之外,关注PCOS女性子代健康并做健康干预;力求对PCOS女性进行全生命周期的健康指导。 入选上海市浦江人才计划、复旦大学十佳百优优秀青年医师、复旦大学附属妇产科医院“拔萃培优”人才计划,主持国家自然基金3项及其他各级课题共9项,作为课题骨干参与科技部重点研发计划2项及国自然重大项目1项。 主要的研究方向是多囊卵巢综合征的病理生理及子代健康的研究。迄今以第一/通讯作者发表SCI论文20余篇,其中包括PNAS、JACI、Allergy、AJOG等TOP期刊。多次参加国内外生殖医学会议并作大会报告。
主要科研项目 主持的课题 (1)国家自然科学基金委员会,面上项目, 2026.01-2029.12, 49万元, 在研,主持 (2)国家自然科学基金委员会,面上项目, 2022.01-2025.12, 54万元, 在研,主持 (3)国家自然科学基金委员会,青年项目, 2019.01-2021.12, 21万元, 已结题,主持 (4)上海市科委/人社局,2020.12-2022.11,30万元, 已结题,主持 (5)生殖遗传教育部重点实验室开放课题,2022.10-2023.9;4万;已结题;主持 (6)浙江省自然科学基金委员会,青年项目, 2018.1-2021.12, 8万元, 已结题,主持 (7)上海市卫生健康委卫生行业临床研究专项, 2021.01-2022.12, 5 万元, 已结题,主持 (8)浙江省中医药管理局青年人才基金项目, 2016.10-2018.9,3万元, 已结题,主持 (9)浙江省医药卫生科技计划项目, 2017.01-2019.12, 已结题,主持 入选的人才计划 (1)上海市浦江人才计划 (2)复旦大学十佳百优优秀青年医师 (3)复旦大学附属妇产科医院“拔萃· 培优”核心人才计划 以课题骨干身份参与的国家自然基金重大项目/科技部重点研发计划 (1)国家自然科学基金委员会, 重大项目, 2022-01-01 至 2026-12-31, 300万元, 在研, 课题骨干 (2)重点研发计划,2021YFC2700603,辅助生殖子代高发出生缺陷致病基因组变异鉴定和功能机制研究(辅助生殖子代遗传问题的临床队列和干预研究),2021.12-2024.11,在研,课题骨干 (3)重点研发计划,2022YFC2703605,功能性出生缺陷一体化综合防控基地及体系建设(功能性出生缺陷疾病病因学研究和精准干预及救助体系构建),2022.12-2024.11,在研,课题骨干
代表性论文(#第一作者,*通讯作者) Metabolome implies increased fatty acid utilization and histone methylation levels in the follicles from hyperandrogenic PCOS women. Journal of Nutritional Biochemistry, 125 (2024) 109548(通讯作者) Associations between visceral adipose tissue area and infertility: a cross-sectional analysis. Reproductive BioMedicine Online, 2024, May 3;49(3):104099(通讯作者) Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. Journal of Neuroinflammation, 2024 Oct 4;21(1):249(共同通讯作者) Association ofMaternal MildHypothyroidism inthe First and ThirdTrimesters withObstetric andPerinatalOutcomes: AProspectiveCohort Study. American Journal of Obstetrics and Gynecology, 2025;232(5):480.e1-480.e19.(共同通讯作者) Identification of CCR7 as a potential biomarker in polycystic ovary syndrome through transcriptome sequencing and integrated bioinformatics. Genomics, 2025, 117(1)110968 (通讯作者) Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation. BBA - Molecular Basis of Disease, 1870 (2024) 167189 (共同通讯作者) Pregnancy-induced metabolic reprogramming in skeletal muscle: a multi-omics interrogation of transcriptional and metabolic adaptations. Acta Biochimica et Biophysica Sinica, 2025(共同通讯作者) One-carbon Metabolism and Risk of PCOS: Insights from Mendelian Randomization. Journal of Ovarian Research, 2025 Nov 3;18(1):235(共同通讯作者) Successful pregnancy after preimplantation genetic testing for structural rearrangements in a couple with complex chromosome rearrangement and recurrent spontaneous abortion: a case report. Journal of Assisted Reproduction and Genetics, 2025(通讯作者) LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis. iScience, 2024, 27(2):108522(共同第一作者) Endometrial receptivity in polycystic ovarysyndrome: altered biomarkers and underlyingmechanisms. Gynecological Endocrinology, 2026 ;42(1):2610550.(共同第一作者) Comparison of genome-wide DNA methylation profiles of human fetal tissues conceived by in vitro fertilization and natural conception. Frontiers in Cell and Developmental Biology, 2021;9 (694769) (共同通讯作者) Associations Between Asthma and Polycystic Ovary Syndrome: Current Perspectives, Frontiers in Endocrinology. 2022;13: 936948 (共同通讯作者) Elevated plasma pentraxin-3 in polycystic ovary syndrome is associated with hyperandrogenism: a case-control study. BMC Endocrine Disorders, 2021, 21:240(通讯作者) Assisted reproductive technology and imprinting errors: analyzing underlying mechanisms from epigenetic regulation, Human Fertility. 2023, 26(4) 864–878 (通讯作者) Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis. Clinical Epigenetics, 2018, 10(1) (第一作者) Elevated ovarian pentraxin-3 in polycystic ovary syndrome. Journal of Assisted Reproduction and Genetics. 2021, 38:1231-1237.(第一作者) Mucosal-associated invariant T cells restrict allergic airway inflammation. The Journal of Allergy and Clinical Immunology, 2020,145(5):1469-1473 (共同第一作者) A critical role for c-Myc in group-2 innate lymphoid cell activation. Allergy, 2020; 75(4)841-852 (共同第一作者) Alternative splicing of the androgen receptor in polycystic ovary syndrome, Proceedings of the National Academy of Sciences, 2015, 112(15): 4743~4748 (共同第一作者)
代表性著作 《Gamete and Embryo-fetal Origins of Adult Disease》编者Springer. 2014 《CACA技术指南-生育保护》副主编 2023年 天津科学技术出版社 《我们如何面对多囊卵巢综合征》编委,2025年6月 浙江科学技术出版社
获奖 (1)针刺和中药组合物在体外受精-胚胎移植中的规范化应用,2022年度中国民族医药学会科学技术奖 二等奖 (2)针刺任督穴位群和口服中药在多囊卵巢综合征治疗中的协同增效作用研究,2016年度浙江省中医药科学技术奖二等奖 |