个人简介（300字） 上海市公共卫生优青，荣获华夏医学奖三等奖。依托复旦大学生殖与发育研究院及复旦妇产科医院，开展妇幼健康公共卫生临床流行病学和基础研究，聚焦妊娠内分泌相关疾病，在深入探索配子/胚胎源性疾病发病机制方面，包括妊娠期甲状腺疾病、妊娠糖尿病等并发症的发病起源性研究及防控方面进行了一系列研究。主持国家自然科学基金青年项目一项、上海市卫生健康委课题二项，国家重点研发计划“生育健康及妇女儿童健康保障”重点专项骨干，开展的“妊娠期甲状腺功能异常相关疾病的机制研究及临床应用”获得2021年度上海市医学科技奖三等奖，以及“晨星”青年奖。参与国家自然科学基金和科技部重大研发计划项目，在妊娠相关疾病研究中积累了相当多的科研工作经验。同时参加了国务院新冠疫情联防联控机制科研攻关组，协助人类遗传资源管理、检测试剂、药物研发、动物模型等科研攻关工作，得到了科技部的高度肯定和表扬。以第一作者或通讯作者在国际内分泌及妇产科权威杂志JCEM, Thyroid, AJOG等杂志发表系列论文，总影响因子超过80分。
主要科研项目 国家自然科学基金委员会, 青年科学基金项目, 82001571, 循环外泌体sFlt-1在妊娠早期低甲状腺素血症对子代宫内发育的影响与机制研究, 2021-01-01 至 2023-12-31, 24万元, 在研, 主持
(2) 上海市卫生健康委员会, 卫生行业临床研究专项, 20224Y0085, 孕早期血清叶酸及同型半胱氨酸水平与妊娠期糖尿病相关性及早期预测模型研究, 2023-01 至 2025-12, 5万元, 在研, 主持 (3) 上海市卫生健康委员会, 卫生行业临床研究专项, 20184Y0349, DNA甲基化及羟甲基化与孕早期镉暴露水平和不良出生结局研究, 2019-01 至 2021-12, 5万元, 结题, 主持 (4) 科技部，十四五国家重点研发计划“生育健康及妇女儿童健康保障”重点专项，2021YFC2701600，早发型子痫前期发病机制及整体化防控策略的研究，2021-01至2025-12，2500万，在研，课题一骨干 (5) 国家自然科学基金委员会, 面上项目, 82171686, 孕期高脂饮食下调子代下丘脑Ramp3诱发糖脂代谢异常及运动干预纠正的机制研究, 2022-01-01 至 2025-12-31, 52万元, 在研, 参与 (6) 国家自然科学基金委员会, 面上项目, 82071622, TSC2突变导致子宫腺肌病的分子机制研究, 2021-01-01 至 2024-12-31, 55万元, 在研, 参与 (7) 国家自然科学基金委员会, 面上项目, 81974235, 胎盘源性外泌体miR-577靶向调控FGF21在妊娠期糖尿病发生中的作用及机制研究, 2020-01-01 至 2023-12-31, 52万元, 在研, 参与
代表性论文（#第一作者，*通讯作者） (1) ChenZhang#; YihuaiLiang#;LijianLei;Guoying Zhu; Xiao Chen;Taiyi Jin*;QingWu*; Hypermethylations of RASAL1 and KLOTHOis associated with renal dysfunction in a Chinesepopulation environmentallyexposedto cadmium,Toxicol Appl Pharmacol, 2013,271(1): 78-85. (2) Chen Zhang#; Xi Yang#; Yong Zhang#; Fei Guo; Shuai Yang; Robin P Peeters; Tim I M Korevaar*; Jianxia Fan*; He-Feng Huang*; Association Between Maternal Thyroid Hormones and Birth Weight at Early and Late Pregnancy, J Clin Endocrinol Metab, 2019, 104(12): 5853-5863. (3) Yong Zhang#; Chen Zhang#; Xi Yang; Shuai Yang; Yu Meng; Zhiwei Liu; Robin P. Peeters; He-Feng Huang*; Tim I.M. Korevaar*; Jianxia Fan*; Association of Maternal Thyroid Function and Thyroidal Response to Human Chorionic Gonadotropin with Early Fetal Growth, Thyroid, 2019, 29(4): 586-594. (4) Wu Y#, Zhang C#, Liu H#, Duan C#, Li C, Fan J, Li H, Chen L, Xu H, Li X, Guo Y, Wang Y, Li X, Li J, Zhang T, You Y, Li H, Yang S, Tao X, Xu Y, Lao H, Wen M, Zhou Y, Wang J, Chen Y, Meng D, Zhai J, Ye Y, Zhong Q, Yang X, Zhang D, Zhang J, Wu X, Chen W, Dennis CL, Huang HF*. Perinatal depressive and anxiety symptoms of pregnant women during the coronavirus disease 2019 outbreak in China. Am J Obstet Gynecol 2020;223:240.e241-240.e249 (5) Lin TT#, Zhang C#, Zhang HQ, Wang Y, Chen L, Dennis CL, Huang H*, Wu YT*. Thyroid Hormone Changes in Early Pregnancy Along With the COVID-19 Pandemic. Frontiers in endocrinology, 2020;11:606723. (6) Fei Guo#; Shuai Yang#; Yong Zhang; Xi Yang; Chen Zhang*; Jianxia Fan*; Nomogram for prediction of gestational diabetes mellitus in urban, Chinese, pregnant women, BMC Pregnancy Childbirth, 2020, 20(1). 43. (7) Lin TT#, Zhang C#, Chen L, Jin L, Lin XH, Pan JX, Dennis CL, Mol BW, Huang HF, Wu YT. COVID-19 Lockdown Increased the Risk of Preterm Birth. Frontiers in medicine, 2021;8:705943 (8) Liu Y#, Guo F#, Maraka S, Zhang Y, Zhang C*, Korevaar TIM*, Fan J*. Associations between Human Chorionic Gonadotropin, Maternal Free Thyroxine, and Gestational Diabetes Mellitus. Thyroid, 2021;31:1282-1288. (9) Mao Y#, Zhang C#, Wang Y, Meng Y, Chen L, Dennis CL, Sheng J, Wu Y*, Huang H*. Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study. Frontiers in endocrinology, 2021;12:706369. (9) Mao Y#, Zhang C#, Wang Y, Meng Y, Chen L, Dennis CL, Sheng J, Wu Y*, Huang H*. Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study. Frontiers in endocrinology, 2021;12:706369. (10) Yang X#, Zhang C#, Williamson C, Liu Y, Zhou Y, Liu C, Chen L, Zhang Y, Korevaar T, Wu W, Fan J*. Association of Maternal Thyroid Function with Gestational Hypercholanemia. Thyroid,2022;32:97-104. (11) Zhang Q#, Zhang C#, Wang Y, Zhao J, Li H, Shen Q, Wang X, Ni M, Ouyang F, Vinturache A, Chen H, Liu Z*. Relationship of maternal obesity and vitamin D concentrations with fetal growth in early pregnancy. European journal of nutrition, 2022;61:915-924. (12) Chen Zhang#, Lilian Bai# , Kuan Sun , Guolian Ding, Xinmei Liu, Yanting Wu* and Hefeng Huang*. Association of maternal triglyceride responses to thyroid function in early pregnancy with gestational diabetes mellitus. Frontiers in endocrinology 2022. 0.3389/fendo.2022.1032705. (13) Ren J#, Jin H#, Zhang C#, Liu S, Han Y, Xi J, Cao J, Lin F, Zhang P, Zhang F, Zhang GH, Yang H, Huang H*, Cao J*. Mixed exposure effect of seminal metals on semen quality, mediation of total antioxidant capacity, and moderation of GSTM1/GSTT1 gene deletion in Chinese reproductive-aged men. Environ Res. 2023. 11;229:115888.
代表性著作 (1) ZhangP, Sun Y,Zhang C, YangY,Zhang L, WangNand Xu H. Cesarean scar endometriosis: presentation of 198 cases andliteraturereview.BMCWOMENS HEALTH 2019, 19: 14. (2) YangX, MengY,Zhang Y,Zhang C, Guo F, YangS, DingR and Fan JX. Thyroid functionreference ranges duringpregnancyinalargeChinesepopulation and comparison with current guidelines.ChinMedJ (Engl)2019, 132: 505-511. (3) Zhang Q, Chen H, Wang Y,Zhang C, Tang Z,LiH, HuangX, OuyangF, HuangH andLiuZ. Severevitamin D deficiencyin the first trimester is associatedwith placental inflammation in high-risk singleton pregnancy.CLINNUTR2019, 38:1921-1926. (4) Sun K, YunL,Zhang C, Shao C, Gao T,ZhaoZ,Hou Y, XieJand Tang Q. Evaluation of 12 Multi-InDel markers for forensic ancestryprediction inAsian populations.ForensicSci Int Genet2019, 43: 102155. (5) Sun T, JiangL,Zhang Z,Zhang C, ZhangH, WangGand QianZ.Feasibility of free-breathingT1-weighted 3Dradial VIBEforfetal MRIin various anomalies. MAGNRESONIMAGING2020, 69: 57-64. (6) Sun F, Qian W,Zhang C, Fan JX and Huang HF. Correlation of Maternal Serum Homocysteine in the First Trimester with the Development ofGestational Hypertension and Preeclampsia.MedSci Monit2017, 23: 5396-5401. (7) Zhang Y, Dai X,YangS,Zhang C, Han M, HuangHF andFan J. Maternal low thyroxin levels are associated with adversepregnancyoutcomes in a Chinese population. PLOSONE2017, 12: e178100. (8) Chen J, ZhangX,Zhang H,Lin J,Zhang C, Wu Q and DingX. Elevated Klotho promotermethylation is associated with severityof chronic kidneydisease. PLOSONE2013, 8: e79856. (9) Fan J, Zhang Y,ZhangC, Barjaktarovic M,YangX, Peeters RP, Huang HF and Korevaar T. Persistencyof Thyroid Dysfunction from EarlytoLate Pregnancy. THYROID 2019, 29: 1475-1484. (10) YangX, Yu Y,Zhang C, et al. The association between isolated maternal hypothyroxinemia in earlypregnancyand pretermbirth.Thyroid. 2020. (11) Guo F,Liu Y, Ding Z,Zhang C,LiuZ,Fan J. Supplemental iodine-containing prenatal multivitamins use and the potential effects on pregnancyoutcomesin amildlyiodine-deficientregion.J Endocrinol Invest. 2020. (12) Wu Y, Liu C, Dong L,ZhangC, Chen Y,Liu J,Zhang C, Duan C,Zhang H, Mol BW, Dennis CL, Yin T, YangJand Huang H. Coronavirus disease2019 among pregnant Chinesewomen: caseseries dataon the safetyof vaginal birth and breastfeeding. BJOG. 2020. (13) Wu YT, Liu J, Xu JJ, Chen YF, YangW, Chen Y,LiC, WangY,Liu H, Zhang C, JiangL,QianZX,Kawai A, Mol BW, Dennis CL, XiongGP, Cheng BH, YangJ, HuangHF. Neonatal outcomein 29 pregnant women with COVID-19: A retrospectivestudyin Wuhan, China.PLoS Med. 2020 Jul 28;17(7):e1003195. (14) Chen Z, Yang X,Zhang C, DingZ,Zhang Y, Korevaar T,Fan J. Thyroid function test abnormalities in twin pregnancies.Thyroid. 2020. (15) Xu C, Li J, Chen S, Cai X, Jing R, Qin X, Pan D, Zhao X, Ma D, Xu X, Liu X, Wang C, Yang B, Zhang L, Li S, Chen Y, Pan N, Tang P, Song J, Liu N, Zhang C, Zhang Z, Qiu X, Lu W, Ying C, Li X, Xu C, Wang Y, Wu Y, Huang HF, Zhang J. Genetic deconvolution of fetal and maternal cell-free DNA in maternal plasma enables next-generation non-invasive prenatal screening. Cell Discov. 2022 13;8(1):109. (16) Wu T, Li T, Zhang C, Huang H, Wu Y. Association between Plasma Trace Element Concentrations in Early Pregnancy and Gestational Diabetes Mellitus in Shanghai, China. Nutrients. 2022. 27;15(1):115. (17) Cheng X, Ji X, Yang D, Zhang C, Chen L, Liu C, Meng X, Wang W, Li H, Kan H, Huang H. Associations of PM2.5 exposure with blood glucose impairment in early pregnancy and gestational diabetes mellitus. Ecotoxicol Environ Saf. 2022. 1;232:113278.
获奖
（1）2021 Shanghai Medical Science and Technology Award, Mechanism research and Clinical application of diseases related to thyroid dysfunction in pregnancy, Shanghai, China.
（2）2023 华夏医学科技奖三等奖, 妊娠甲状腺功能异常的机制研究及临床防治, 中国医疗保健国际交流促进会, 中国.
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