张宇，复旦大学生殖与发育研究院/附属妇产科医院青年研究员，国家青年拔尖人才，入选上海市2023年度“科技创新行动计划”启明星项目（扬帆专项）。长期利用分子生物学、发育生物学和计算生物学的方法，探索表观遗传信息在配子发生及早期胚胎发育中的动态变化、作用机制及其生物学功能，共发表高水平SCI论文20余篇，其中包括以第一及共同第一作者身份在Nature Genetics（x2）、Molecular Cell（Molecular Cell邀请Victor Corces为文章撰写Previews，高度评价了该成果）、Science Advances、Genome Research等发表论文8篇，研究成果获领域内广泛关注与认可，被包括Nature Reviews Genetics、Nature、Science在内的高水平综述及研究论文引用，总引用数超过1500次（谷歌学术）。
主要科研项目 1.cohesin与SYCP3协同调控精母细胞减数分裂联会复合体形成过程中染色质三维结构建立的分子机制，国家自然科学基金委员会面上项目，32370574，主持。 2.DNMT3A介导妊娠期糖尿病影响雄性子代生殖细胞DNA甲基化重编程的机制研究，国家自然科学基金委员会青年科学基金项目，82301931，主持。 3.哺乳动物配子发生和早期胚胎发育中染色质三维结构重编程研究，国家自然科学基金委员会重点项目, 31830047,参与。 4.细胞记忆产生与维持的表观遗传机制-信号诱导细胞记忆的表观遗传机制，国家重点研发计划, 2019YFA0508901,参与。 5.早期胚胎基因组启动与异常发育相关研究，北京市科学技术委员会生命科学前沿创新培育, Z181100001318006，参与。
代表性论文（#第一及共同第一作者，*通讯及共同通讯作者） Zhang Y#, Xiang YL#, Yin QZ#, Du ZH#, Peng X, Wang QJ, Fidalgo M, Xia WK, Li YY, Zhao ZA, Zhang WH, Ma J, Xu F, Wang JL, Li L, Xie W. Dynamic epigenomic landscapes during early lineage specification in mouse embryos. Nature Genetics. 2018. Wang Y#, Wang H#,Zhang Y#, Du ZH#, Si W#, Fan SX, Qin DD, Wang M, Duan YC, Li LF, Jiao YY, Li YY, Wang QJ, Shi QH, Wu X*, Xie W*. Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis. Molecular Cell. 2019. Xiang YL#, Zhang Y#, Xu QH, Zhou C, Liu B, Du ZH, Zhang K, Zhang BJ, Wang XX, Gayen S, Liu L, Wang Y, Li YY, Wang QJ, Kalantry S, Li L, Xie W. Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency. Nature Genetics. 2020. Lu XK#, Zhang Y#, Wang LJ#, Wang LY#, Wang HL, Xu QH, Xiang YL, Chen CL, Kong F, Xia WK, Lin ZL, Ma SN, Liu L, Wang XG, Ni HM, Li W*, Guo Y*, Xie W*. Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting. Science Advances. 2021. Xu JW#, Shu YM#, Yao GD#, Zhang Y#, Niu WB, Zhang YL, Ma XS, Jin HX, Zhang FL, Shi SL, Wang Y, Song WY, Dai SJ, Cheng LY, Zhang XY, Xie W*, Hsueh Aaron J*, Sun YP*. Parental methylome reprogramming in human uniparental blastocysts reveals germline memory transition. Genome Research.2021. Liu YH#, Xu Z#, Shi JJ#, Zhang Y#, Yang ST#, Chen Q, Song CL, Geng SH, Li Q, Li JS, Xu GL, Xie W, Lin HD, Li XJ. DNA methyltransferases are complementary in maintaining DNA methylation in embryonic stem cells. iScience. 2022. Zhang Y and Xie W*. Building the Genome Architecture during Maternal to Zygotic Transition. Current Opinion in Genetics & Development. 2022. Xu Zhen#, Shi Jiajia#, Zhang Yu#, Liu Yuhan, Zhao Junzheng, Chen Qian, Song Chenglin, Geng Shuhui, Xie Wei, Wu Feizhen, Bai Yun, Yang Yang, Li Xiajun. Zfp57 exerts maternal and sexually dimorphic effects on genomic imprinting. Frontiers in Cell and Developmental Biology, 2022. Mo JY, Liu XQ, Huang YT, He RK, Zhang Y*, Huang HF*. Developmental origins of adult diseases. Medical review. 2022.
参与作者文章： Zhang B, Yang YW, Zhang Y, Liu JY*. A high-confidence reference dataset of differentially expressed proteins in elongating cotton fiber cells. Proteomic. 2013. Yao SX,Zhang Y, Chen YL, Deng HT, Liu JY*. SILARS: An Effective Stable Isotope Labeling with Ammonium Nitrate-15N in Rice Seedlings for Quantitative Proteomic Analysis. Molecular Plant. 2014. Zhang WH#, Xia WK#, Wang QJ, J Towers J Aaron, Chen JY, Gao R, Zhang Y, Yen CA, Lee AY, Li YY, Zhou C, Liu KL, Zhang J, Gu TP, Chen XQ, Chang Z, Leung Danny, Gao SR, Jiang TH & Xie W. Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development. Molecular Cell. 2016. Zhang BJ#, Zheng H#, Huang B#, Li WZ#, Xiang YL, Peng X, Ming J, Wu XT, Zhang Y, Xu QH, Liu WQ, Kou XC, Zhao YH, He WT, Li C, Chen B, Li YY, Wang QJ, Ma J, Yin QZ, Kee KK, Meng AM, Gao SR, Xu F, Na J*& Xie W*. Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature. 2016. Zhang BJ#, Wu XT#, Zhang WH#, Shen WM, Sun QR, Liu KL, Zhang Y, Wang QJ, Li YY, Meng AM*, Xie W*. Widespread Enhancer Dememorization and Promoter Priming during Parental-to-Zygotic Transition. Molecular Cell. 2018. Li YY#, Zheng H#, Wang QJ, Zhou C, Wei L, Liu XH, Zhang WH, Zhang Y, Du ZH, Wang XW, Xie W. Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys. Genome Biology. 2018. Xu QH#, Xiang YL#, Wang QJ#, Wang LY#, Amour J.B., BogutzA.B., ZhangY,Zhang BJ, Yu G, Xia WK, Du ZH, Huang CY, Ma J, Zheng H, Li YY, Liu C,Walker C. L., Jonasch E, Lefebvre L, Wu M, Lorincz M, Li W*, Li L*, Xie W*. SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development. Nature Genetics. 2019. Ye M#, Yang Z#, Zhang Y, Xing Y, Xie Q, Zhou J, Wang L,Xie W, Kee K*, Chian R*. Single-cell multiomic analysis of in vivo and in vitro matured human oocytes. Human Reproduction. 2020. Wang QJ#, Yu G#, Ming X#, Xia WK, Xu XG, Zhang Y, Zhang WH, Li YY, Huang CY, Xie HH, Zhu B*, Xie W*. Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance. Nature Genetics. 2020. Quan H#, Tian H#, Liu SR#, Xue Y, Zhang Y, Xie W, Gao YQ. Progressive Domain Segregation in Early Embryonic Development and Underlying Correlation to Genetic and Epigenetic Changes. Cells. 2021. Wang XX#, Xiang YL#, Yu Y#, Wang R, Zhang Y, Xu QH, Sun H, Zhao ZA, Jiang XX, Wang XQ, Lu XK, Qin DD, Quan YJ, Zhang JQ, Chang NS, Wang HM , Jing NH, Xie W*, Li L*. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Research. 2021. Jiang WJ#, Shi JJ#, Zhao JJ#, Wang Q#, Cong D#, Chen FH#, Zhang Y, Liu YH, Zhao JZ, Chen Q, Gu LH, Zhou WJ, Wang CH, Fang ZY, Geng SH, Xie W, Chen LN, Yang Y, Bai Y*, Lin HD*, Li XJ*. ZFP57 dictates allelic expression switch of target imprinted genes. PNAS. 2021. Wu Xiaotong#, Zhang Hongmei#, Zhang Bingjie#, Zhang Yu, Wang Qiuyan, Shen Weimin, Wu Xi, Li Lijia, Xia Weikun, Ryohei Nakamura, Liu Bofeng, Liu Feng, Hiroyuki Takeda, Meng Anming, Xie Wei.Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs. Science Advances. 2021.
代表性著作 1.《承续的魅力：令人着迷的表观遗传学》 表观遗传信息的遗传与重编程，科学出版社，2018，参与编写.
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