复旦大学附属妇产科医院主任医师、博士生导师。专注于提高辅助生殖技术的母婴安全性及生殖健康领域的难点问题的技术改良,尤其聚焦排卵障碍性不孕(如多囊卵巢综合征)的机制及干预的转化医学研究。作为项目负责人,主持国家级课题3项,省部级课题共计4项。现担任上海医学会生殖医学分会副主任委员,中国女医师协会生殖医学专业委员会常委,中国医疗保健国际交流促进会生殖医学分会常委,中国妇幼保健协会辅助生殖技术监测与评估专业委员会常委,上海市人类辅助生殖技术质量控制委员会委员,《中华生殖与避孕杂志》编委, 《Human Reproduction Update》中文版青年编委。参与国家十三五规划教材编写1部,参与专著编写3部,共同制定行业标准2项。
主要科研项目 辅助生殖子代遗传问题的临床队列与干预研究/辅助生殖子代高发出生缺陷的致病基因组变异鉴定和功能机制研究,国家重点研发计划,2021YFC2700603,课题负责人; 子宫内膜容受性异常的精准诊治及相关着床障碍疾病防治,国家重点研发计划,2022YFC2702500,子课题,项目骨干; 中国人群辅助生殖人口及子代队列建立与应用基础研究(辅助生殖技术子代胎源性疾病队列研究),国家重点研发计划专项、2016YFC1000203-3,项目骨干; 基于立体化网络建设出生缺陷综合防控示范应用体系,国家重点研发计划专项,2018YFC1002401,项目骨干; miR125b介导AR剪接变异体抑制PCOS卵巢颗粒细胞凋亡的机制研究,国家自然科学基金面上项目,81871140; 主持内皮素-1促进人卵母细胞成熟及其机制研究,国家自然科学基金面上项目,81170567,参加(排名第二); 颗粒细胞PPARG基因剪接变体在PCOS发病机制中的作用,国家自然科学基金面上项目,81671412,参加(排名第二); 卵母细胞与颗粒细胞通过CFTR以HCO3-进行对话机制的研究,国家自然科学基金青年项目,31100986,主持; 智能超声图像处理和在线辅助诊断技术在卵泡监测中的应用,上海交通大学医工交叉项目、YG2016MS44,主持; PiRNAs及其PIWI蛋白在睾丸精子发生调控中的作用及其机制研究,浙江省自然科学基金项目,Y2110191参加; 右归丸结合克罗米芬在多囊卵巢综合征患者促排卵治疗中的临床研究,浙江省中医药科学研究基金、2011ZA064,参加; 辅助生殖技术对母婴健康的影响:IVF出生队列研究和多中心、前瞻性、随机临床试验,上海市级医院临床技能与临床创新三年行动计划,16CR1022A,分中心负责人; 植入前胚胎遗传学筛查(PGS 2.0)对不明原因复发性流产患者临床结局影响的多中心前瞻性随机对照研究,上海申康医院发展中心临床科技创新项目,SHDC12017105,分中心负责人; 阴道用乳酸杆菌胶囊预处理改善菌群失调的PCOS患者FET结局的多中心随机对照研究,上海市级医院临床技能与临床创新三年行动计划重大临床研究项目,SHDC2020CR1008A,执行骨干。
代表性论文(#第一作者,*通讯作者) Lin H#, Zhao Y#, Zhu Y, Li C, Xu W, Chen X*, Huang H*, Jin L*. Maternal High-Fat Diet Aggravates Allergic Asthma in Offspring via Modulating CD4+ T-Cell Differentiation. Nutrients. 2022 Jun 16;14(12):2508. (IF:6.706) Songchang# Chen, Qian Zhang#, Liming Chu#, Chunxin Chang, Yiyao Chen, Zhongwei Bao, Weihua Peng, Lanlan Zhang, Shuyuan Li, Chao Liu, Huanhuan Zhu, Feng Yu, Xiaoyan Chen, Lili Jiang, Daru Lu, Zhengwen Jiang*, Li Jin*, Chenming Xu*. Comprehensive copy number analysis of Y chromosome-linked loci for detection of structural variations and diagnosis of male infertility. Journal of Human Genetics. 2022 Feb; 67(2): 107-114..(IF:3.172) Hong Zhu#, Si-si Luo#, Yi Cheng, Yi-shang Yan, Ke-xin Zou, Guo-lian Ding, Li Jin*, He-feng Huang*. Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mice Pancreas. Frontiers in Endocrinology. 2021 Aug;12: 710221 (IF:5.556) Ye Liu#, Xinzhu L#, Songchang Chen, Li Wang, Yajing Tan, Xiaocui Li, Lin Tang, Junyu Zhang, Dandan Wu, Yanting Wu, Xinmei Liu, Yimin Zhu, Jianzhong Shen, Jiexue Pan*, Li Jin*, Hefeng Huang*. Comparison of Genome-Wide DNA Methylation Profiles of Human Fetal Tissues Conceived by in vitro Fertilization and Natural Conception. Frontiers in Cell and Developmental Biology. 2021 Jul 14; 9:694769(IF:6.684) Chen Luting#, Huixi Chen#, Xiaojin Wang, Bing Wei, Zhengmu Wu, Songchang Chen, Bingshun Wang, Hefeng Huang*, Li Jin*. Association of homocysteine with IVF/ICSI outcomes stratified by MTHFR C677Tpolymorphisms: a prospective cohort study. Reproductive Biomedicine Online. 2021 April 43(1):52-61. (IF:3.828) Jiexue Pan, Chengliang Zhou, Zhiyang Zhou, Zuwei Yang, Tiantian Dai, Hefeng Huang*, Li Jin*. Elevated ovarian pentraxin-3 in polycystic ovary syndrome. Journal of Assisted Reproduction and Genetics. 2021 May; 38(5): 1231-1237. (IF:3.412) Zuwei Yang#, Wenzhong Zhou#, Chengliang Zhou, Yuzhong Zhou, Xinmei Liu, Guolian, Ding, Yulian Hu, Jiexue Pan, Jianzhong Sheng, Li Jin*, Hefeng Huang*. Steroid metabolome profiling of follicular fluid in normo- and hyperandrogenic women with polycystic ovary syndrome. Journal of Steroid Biochemistry and Molecular Biology. 2021 Feb 206: 105806. (IF:4.292) YaoyaoTu#, GuangyongZheng#, Guolian Ding, Yanting Wu, Ji Xi, YingzhouGe, HangchaoGu, Yingyu Wang, Jianzhong Sheng, Xinmei Liu*, Li Jin*, HefengHuang*. Comparative analysis of lower genital tract microbiome between PCOS and healthy women. Frontiers in Physiology. 2020 Sep 8; 11:1108. (IF:4.566) Luting Chen#, Huixi Chen#, Xinmei Liu, Jingyi Li, QianGao, Shuai Shi, Tingting Wang, Xiaoqun Ye, Yongchao Lu, Dan Zhang, Jianzhong Sheng, Li Jin*,Hefeng Huang*. AQP7 mediates postmenopausal lipogenesis in adipocytes through FSH-induced transcriptional crosstalk with AP-1 sites. Reproductive BioMedicine Online. 2020 Nov 24 (IF:3.828) Cheng-Liang Zhou#, Gu-Feng Xu#, Qian Yang #, Hui-Hui Wang , Meng-Xi Guo, Yi-Meng Xiong, Xiao-Yan Guo, Min Hou, Lu-Yang Jin, Jian-Zhong Sheng, Lin He, Li Jin*, He-Feng Huang*. Diminished verbal ability among children conceived through ART with exposure to high serum estradiol in utero. J Assist Reprod Genet. 2020 Aug;37(8);1931-1938. (IF:3.412) Jiang Z#, Jin L#, Shi W, Xi J, Hu Y, Liu X, Sheng J, Ding G, Huang H. A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis. Sci China Life Sci. 2019 Jan; 62(1): 112–118. (IF:6.038) Jin L#, Yang Q#, Zhou C, Liu L, Wang H, Hou M, Wu Y, Shi F, Sheng J, Huang H. Profiles for long non-coding RNAs in ovarian granulosa cells from women with PCOS with or without hyperandrogenism. Reprod Biomed Online. 2018 Aug; 37(5):613-623. (IF:3.828) Köster F#*, Jin L#, Shen Y#, Schally AV, Cai RZ, Block NL, Hornung D7, Marschner G, Rody A, Engel JB, Finas D. Effects of an Antagonistic Analog of Growth Hormone-Releasing Hormone on Endometriosis in a Mouse Model and In Vitro. Reproductive Science. 2017 Nov; 24(11):1503-1511.(IF:2.616) Jin L#,Zhu XM#, Luo Q, Qian Y, Jin F, Huang HF*. A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS. Mol Hum Reprod. 2006, 12(3):151-155.
陈露婷,金丽*。女性超重或肥胖对体外受精和(或)卵胞浆内单精子注射结局影响的Meta分析。上海医学,2018,41(1):34-42. 金丽,潘洁雪,丁国莲,黄荷凤*。辅助生殖周期中超促排卵对子宫内膜容受性的影响。中国实用妇科与产科杂志,2015,31(1):31-35. 蔡丽君,陈松长,徐晨明,黄荷凤*,金丽*。“5G+区块链”赋能植入前遗传学检测技术用于罕见病的精准防控。中华生殖与避孕杂志,2021 41(6):486-495. 中国医师协会生殖医学专业委员会。孕激素维持妊娠与黄体支持临床实践指南。中华生殖与避孕杂志,2021 41(2):95-105.
代表性著作 《实用人类辅助生殖技术》,专著,2018,人民卫生出版社,编委; 《植入前遗传学诊断临床实践》,专著,2018,上海交通大学出版社,编委; 《生殖医学》,专著,2021,人民卫生出版社,编委; 《中华妇产科学》,专著,2022,人民卫生出版社,编委; 《孕激素维持妊娠与黄体支持临床实践指南》,指南,2021,参编; 《基于Delphi法的辅助生殖技术治疗低预后人群诊疗中国专家意见》,指南,2020,参编。
获奖 生殖过程调控及相关疾病分子机理,妇幼健康科学技术奖科技成果一等奖,中国妇幼健康研究会,第十完成人,2015年。
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