个人简介（300字） 复旦大学附属妇产科医院遗传中心副主任，分子诊断实验室负责人，中国遗传学会生殖遗传分会委员，中国医院协会妇产医院分会委员，上海市医学会分子诊断专科分会青年委员，上海市医师协会临床遗传专委会委员兼秘书，中国遗传学会遗传诊断分会秘书。围绕出生缺陷防控的关键科学技术问题，将基础研究和临床问题紧密结合，取得了一系列具有影响力的创新性研究成果，并积极将研究成果临床转化应用，成果入选国家十三五科技成果成就展；作为共同第一作者撰写PGT国际指南；主持国家自然基金、上海市自然基金、上海市科技创新专项等项目12项；以第一作者或通讯作者在Nature Medicine、Cell Discovery、Protein & Cell和AJOG等杂志发表SCI论文40余篇；副主编教材1部，参编教材和著作5部；申请国家发明专利15项，1项实现成果转化；获得软件著作权4项；获得国家科技进步奖二等奖和上海市科技进步奖一等奖各1次；入选上海市东方英才、上海市扬帆人才、上海市医苑新星医学人才和复旦大学临床科学家计划等。
主要科研项目 国家自然基金青年项目，81901495，母体cfRNA表达量变化与自发性早产发生风险的相关性及机制研究，主持 上海市自然科学基金面上项目，23ZR1408000，lnc-CBR1-1介导TNF-α/NF-κB信号通路在自发性早产中的机制研究，主持 上海市卫健委，202140110，SNV-array在高风险胎儿产前诊断中的临床应用研究，主持 上海市科委项目，18YF1424800，基于扩增子高通量测序技术的无创产前单基因病诊断技术研究，主持 上海市卫健委医学新技术研究与转化种子计划项目，2024ZZ2017，产前染色体病快速检测技术开发和临床转化应用，主持 上海市卫健委，201972，基于stLFR技术的ADPKD新生变异患者PGD研究，主持 2025年度复旦大学上海医学院，临床科学家培养计划，主持 国家重点研发计划，2018YFC1004900，辅助生殖的遗传安全性研究，骨干 国家自然科学基金-重大项目，82192864，听力障碍的高效预防、预警策略，骨干 国家重点研发计划，2022YFC2703702，肢体发育缺陷的病因学研究及精准防治体系构建，骨干 国家重点研发计划，2023YFC2705603，多种类型遗传疾病的无创产前同步式筛查新技术与临床研究，骨干
代表性论文（#第一作者，*通讯作者） Songchang Chen*#, Wenqiu Xu*, Li Zhang*, Xiaorui Luan,, Mengdi Liu, Hong You, Weihui Shi, Xuanyou Zhou, Zhen Yang,Yun Yang, Chenming Xu#. Expanded Non-Invasive Prenatal Screening for Dominant Single-Gene Disorders: Proof-of-concept, Performance, and Challenges[J]. American Journal of Obstetrics and Gynecology. 2025 Jun 21:S0002-9378(25)00422-3. Songchang Chen*#; Chang Liu*; Xiaorui Luan*; Yuling Wang; Yuexin Xu; Yunshuang Li; Fenjiao Zhang; Weihui Shi; Xuanyou Zhou; Chenming Xu#, Application and clinical utility assessment of natural language processing-based software for copy-number variants interpretation, Journal of Translational Medicine,2025. Songchang Chen*, Li Wang*, Luting Chen*, Weihui Shi*, Junyu Zhang, Yuting Hu, Yinyu Wang, Li Jin, Jianzhong Sheng, Feng Zhang, Yanting Wu#, Hefeng Huang#, Chenming Xu#. A novel preimplantation genetic testing strategy for a subtelomeric genetic disorder- a case study. Genes & Diseases, 2024, 11(4): 101014. Jinglan Zhang*, Yanting Wu*, Songchang Chen*, Qiong Luo*, Hui Xi*, Jianli Li, Xiaomei Qin, Ying Peng, Na Ma, Bingxin Yang, Xiang Qiu, Weiliang Lu, Yuan Chen, Ying Jiang, Panpan Chen, Yifeng Liu, Chen Zhang, Zhiwei Zhang, Yu Xiong, Jie Shen, Huan Liang, Yunyun Ren, Chunmei Ying, Minyue Dong, Xiaotian Li, Congjian Xu, Hua Wang#, Dan Zhang#, Chenming Xu#, He-Feng Huang#, Prenatal cell-free DNA screening for genetic conditions of heterogenous etiologies: a prospective, multicenter cohort study[J]. Nature Medicine, 2024, 30(2): 470-479. Xu, Chenming#*, Li, Jianli*, Chen, Songchang*, Cai, Xiaoqiang*, Jing, Ruilin, Qin, Xiaomei, Pan, Dong, Zhao, Xin, Ma, Dongyang, Xu, Xiufeng, Liu, Xiaojun, Wang, Can, Yang, Bingxin, Zhang, Lanlan, Li, Shuyuan, Chen, Yiyao, Pan, Nina, Tang, Ping, Song, Jieping, Liu, Nian, Zhang, Chen, Zhang, Zhiwei, Qiu, Xiang, Lu, Weiliang, Ying, Chunmei, Li, Xiaotian, Xu, Congjian, Wang, Yanlin, Wu, Yanting#, Huang, He-Feng#, Zhang, Jinglan#. "Genetic deconvolution of fetal and maternal cell-free DNA in maternal plasma enables next-generation non-invasive prenatal screening". Cell Discovery, 2022, 8 (1). Songchang Chen*, Xiaofang Cheng, Dan Chen, Huijuan Yan, Jun Xia, Ping Liu, Xuyang Yin, Fang Chen, Chenming Xu#.Single tube long fragment read (stLFR) with massively parallel sequencing achieved patient-only haplotyping for preimplantation genetic testing of monogenic disorders. Human Reproduction, 2020; 351: 78-78. Songchang Chen*, Xuyang Yin*, Sijia Zhang*, Jun Xia, Ping Liu, Pingyuan Xie, Huijuan Yan, Xinming Liang, Junyu Zhang，Yiyao Chen, Hongjun Fei1, Lanlan Zhang, Yuting Hu, Hui Jiang, Ge Lin, Fang Chen#, Chenming Xu#, Comprehensive preimplantation genetic testing by massively parallel sequencing, Human Reproduction, 2021.5.19;36(1):236-247. Songchang Chen*, Shuyuan Li* , Junyu Zhang , Lanlan Zhang , Yiyao Chen , Li Wang , Li Jin , Yuting Hu , Xiaoping Qi #, Hefeng Huang #, Chenming Xu #, Preimplantation genetic diagnosis of multiple endocrine neoplasia type 2A using informative markers identified by targeted sequencing, Thyroid, 2018 , 3(28): 281-287. Chen, SongChang*, Liu, DeYuan*., Zhang, JunYu*., Li, ShuYuan., Zhang, LanLan., Fan, JianXia., Luo, YuQin., Qian, YeQian., Huang, HeFeng., Liu, Chao., Zhu, HuanHuan., Jiang, ZhengWen#., & Xu, ChenMing#. A copy number variation genotyping method for aneuploidy detection in spontaneous abortion specimens, Prenat Diagn, 2017, 37(2), p176-183. Hongjun Fei*, Songchang Chen*, Chenming Xu#, Interactive verification analysis of multiple sequencing data for identifying Potential Biomarker of lung adenocarcinoma, BioMed Research International. Volume 2020, Article ID 8931419, 18 p Hongjun Fei*, Songchang Chen*, Chenming Xu#, Construction autophagy-related prognostic risk signature to facilitate survival prediction, individual treatment and biomarker excavation of epithelial ovarian cancer patients. Journal of Ovarian Research, 2021. 14(1). Hongjun Fei*, Songchang Chen*, Chenming Xu#, Construction autophagy-related prognostic risk signature combined with clinicopathological validation analysis for survival prediction of kidney renal papillary cell carcinoma patients. BMC Cancer, 2021. 21(1). Wei-Hui Shi*, Zi-Ru Jiang, Zhi-Yang Zhou, Mu-Jin Ye, Ning-Xin Qin, He-Feng Huang, Song-Chang Chen #, Chenming Xu #, Different strategies of preimplantation genetic testing for an-euploidies in women of advanced maternal age: a systematic review and meta-analysis. Journal of Clinical Medicine, 2021 Aug 30;10(17):3895. Xu, Chenming*. Cai, Xiaoqiang*. Chen, Songchang*. Luo, Qiong. Xi, Hui. Zhang, Dan. Wang, Hua. Wu, Yanting. Huang, He-Feng#. Zhang, Jinglan#. Comprehensive non-invasive prenatal screening for pregnancies with elevated risks of genetic disorders: protocol for a prospective, multicenter study, BMJ Open, 2021, 11(8), e53617. Chen, Songchang*, Zhang, Qian*, Chu, Liming*, Chang, Chunxin, Chen, Yiyao, Bao, Zhongwei, Peng, Weihua, Zhang, Lanlan, Li, Shuyuan, Liu, Chao, Zhu, Huanhuan, Yu, Feng, Chen, Xiaoyan, Jiang, Lili, Lu, Daru, Jiang, Zhengwen#, Jin, Li#, Xu, Chenming#, "Comprehensive copy number analysis of Y chromosome-linked loci for detection of structural variations and diagnosis of male infertility". Journal of human genetics, 2022, 67 (2): 107-114. Wu, Wenman*, Zhou, Xuanyou*, Jiang, Zhengwen*, Zhang, Dazhi, Yu, Feng, Zhang, Lanlan, Wang, Xuefeng#, Chen, Songchang#, Xu, Chenming#. "Noninvasive fetal genotyping of single nucleotide variants and linkage analysis for prenatal diagnosis of monogenic disorders". Human Genomics, 2022, 16 (1). Naixin Xu*, Weihui Shi*, Xianling Cao, Xuanyou Zhou, Hefeng Huang，Songchang Chen#, Chenming Xu#., Parental mosaicism detection and preimplantation genetic testing in families with multiple transmissions of de novo mutations. Journal of Medical Genetics, 2023: p. jmg-2022-108920. Yiyao Chen*, Bingxin Yang*, Xiaoyu Merlin Zhang*, Songchang Chen*, Minhui Wang, Liya Hu, Nina Pan, Shuyuan Li, Weihui Shi, Zhenhua Yang, Li Wang, Yajing Tan, Jian Wang, Yanlin Wang, Qinghe Xing, Zhonghua Ma, Jinsong Li, He-feng Huang#, Jinglan Zhang#, Chenming Xu#. Biallelic variants in RBM42 cause a multisystem disorder with neurological, facial, cardiac, and musculoskeletal involvement. Protein & Cell, 2024,15(1),52-68. Jinghua Sun*, Wen-Jing Wang*, Xuanyou Zhou*, Tingyu Yang, Mujin Ye, Weihui Shi, Zhongzhen Liu, Lanlan Zhang, Qing Zhou, Yulong Qin, Yiyao Chen, Fang Chen, Hefeng Huang, Songchang Chen#, Chenming Xu#. Early characterisation and prediction of liver diseases in pregnancy by plasma cell-free RNAs [J]. Clinical and Translational Medicine, 2023, 13(10): e1439. Songchang Chen*#, Li Wang*, Yuting Hu, Yaxin Yao, Fangfang Gao，Chunxin Chang, Lanlan Zhang, Hefeng Huang, Daru Lu, Chenming Xu#. Noninvasive preimplantation genetic testing for aneuploidy using blastocyst spent culture medium may serve as a backup of trophectoderm biopsy in conventional preimplantation genetic testing. BMC Medical Genomics, (2025) 18:34 Xu, Chenming*#, Songchang Chen*, Yangyun Zou*, Yulin Chen, Yanting Wu, Congjian Xu, Yingying Xia, Guobo Chen, Li Jin#, Sijia Lu#, and Hefeng Huang#, Preimplantation genetic testing for type 2 diabetes based on family-specific polygenic risk score: A proof-of-concept study. Diabetes Research and Clinical Practice, (2025)225: 112226.
代表性著作（参编） （1）《临床检验一万个为什么·遗传检验分册》，人民卫生出版社，2018年，北京 （2）《植入前遗传学诊断临床实践》，上海交通大学出版社，2018年，上海 （3）《实用人类辅助生殖技术》，人民卫生出版社，2018年，北京 （4）《三孩时代：孕妈妈优生与产前诊断指导手册》，浙江大学出版社，2023年，杭州 （5）《遗传咨询》，高等教育出版社，2024年，上海
获奖 陈松长(5/10); 发育源性疾病和遗传性出生缺陷的机制研究及临床精准防控, 中华人民共和国国务院, 国家科技进步,二等奖, 2021 陈松长(6/15); 发育源性疾病和遗传性出生缺陷的机制研究及临床精准防控, 上海市人民政府, 省部科技进步,一等奖, 2020 2018年上海交通大学附属国际和平妇幼保健院首届“十佳青年” 2015年-2019年连续5年院级先进工作者 2019年入选上海市医苑新星医学人才计划 2019年入选上海交通大学晨星人才计划（C类） 2018年入选上海市扬帆人才计划（省部级） 2021年入选复旦大学附属妇产科医院拔萃核心人才 2023年复旦大学十大医务青年提名奖 陈松长(4/5); 2022年度复旦大学“十大科技进展”提名奖；下一代无创产前筛查实现染色体和单基因病的同步检测； 2023年复旦大学“十佳百优”优秀医技工作者 2023年度上海东方英才计划青年项目（综合平台） 2022和2024年度复旦大学附属妇产科医院优秀医技人员 2025年入选复旦大学临床科学家培养计划
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